Yıl: 2020 Cilt: 9 Sayı: 3 Sayfa Aralığı: 708 - 713 Metin Dili: İngilizce DOI: 10.5455/medscience.2019.04.049 İndeks Tarihi: 21-10-2020

Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals

Öz:
Thalassemia is the most frequently seen monogenetic disorders around the world that is inherited as a recessive single-gene disease, resulting from mutations in α-orβ-globin gene clusters. In this study Beta Thalassemia Intermedia, Beta Thalassemia Minor, Sickle Cell Disease patients and the healthy control individuals both incidence and serum parameters were examined and analyzed retrospectively between 2015-2017 from Public Health information system. Beta Thalassemia Intermedia, BetaThalassemia Major, Beta Thalassemia Minor and Sickle Cell Disease patient groups incidences were evaluated on the basis of their HPLC analysis. Patients and controlgroups serum parameters levels were analyzed from their autoanalyzer results. These serum biochemical tests datas were controlled and taken from Siirt Public HealthCentre information system. In each year, there were recorded approximately 12 Beta Talassemia patients, 2 Beta Thallassemia Major patients, 340 Beta ThalassemiaMinor patients and 33 Sickle Cell Disease patients.Beta Thalassemia Intermedia patients serum parameters levels were compared with Beta Thalassemia Minor Patientsserum parameters and control group serum levels. There were seen statisticaly significant difference between Beta Thalassemia Intermedia patient’s serum ast, albumin,creatine, amylase, phosphor, iron, iron binding capacity, total protein, sodium, bilirubin direct, bilirubin total, LDH level and control serum parameters levels, p<0.05. Butthere were not seen statistically significant differences between Beta Thalassemia Minor patients serum levels and control serum levels. Studies like this should be donenationwide, in each city to determine the current state of abnormal hemoglobinopathies in Turkey. Thus, a broader, comprehensive national screening program is needed.
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APA YERLİKAYA E, KARAGEÇİLİ H, KAYA M (2020). Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals. , 708 - 713. 10.5455/medscience.2019.04.049
Chicago YERLİKAYA Emrah,KARAGEÇİLİ HASAN,KAYA Mustafa Oğuzhan Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals. (2020): 708 - 713. 10.5455/medscience.2019.04.049
MLA YERLİKAYA Emrah,KARAGEÇİLİ HASAN,KAYA Mustafa Oğuzhan Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals. , 2020, ss.708 - 713. 10.5455/medscience.2019.04.049
AMA YERLİKAYA E,KARAGEÇİLİ H,KAYA M Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals. . 2020; 708 - 713. 10.5455/medscience.2019.04.049
Vancouver YERLİKAYA E,KARAGEÇİLİ H,KAYA M Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals. . 2020; 708 - 713. 10.5455/medscience.2019.04.049
IEEE YERLİKAYA E,KARAGEÇİLİ H,KAYA M "Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals." , ss.708 - 713, 2020. 10.5455/medscience.2019.04.049
ISNAD YERLİKAYA, Emrah vd. "Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals". (2020), 708-713. https://doi.org/10.5455/medscience.2019.04.049
APA YERLİKAYA E, KARAGEÇİLİ H, KAYA M (2020). Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals. Medicine Science, 9(3), 708 - 713. 10.5455/medscience.2019.04.049
Chicago YERLİKAYA Emrah,KARAGEÇİLİ HASAN,KAYA Mustafa Oğuzhan Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals. Medicine Science 9, no.3 (2020): 708 - 713. 10.5455/medscience.2019.04.049
MLA YERLİKAYA Emrah,KARAGEÇİLİ HASAN,KAYA Mustafa Oğuzhan Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals. Medicine Science, vol.9, no.3, 2020, ss.708 - 713. 10.5455/medscience.2019.04.049
AMA YERLİKAYA E,KARAGEÇİLİ H,KAYA M Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals. Medicine Science. 2020; 9(3): 708 - 713. 10.5455/medscience.2019.04.049
Vancouver YERLİKAYA E,KARAGEÇİLİ H,KAYA M Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals. Medicine Science. 2020; 9(3): 708 - 713. 10.5455/medscience.2019.04.049
IEEE YERLİKAYA E,KARAGEÇİLİ H,KAYA M "Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals." Medicine Science, 9, ss.708 - 713, 2020. 10.5455/medscience.2019.04.049
ISNAD YERLİKAYA, Emrah vd. "Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals". Medicine Science 9/3 (2020), 708-713. https://doi.org/10.5455/medscience.2019.04.049