Objective: We aimed to evaluate epidemiological characteristics and caregiving burden of caregivers of children with chronic illness who referred to our pediatric emergency department and evaluate the relationship between them. Material and Methods:Caregivers of 105 patients under 18 years of age who were followed for any chronic disease were included in the study. Zarit Burden Interview (ZBI) was used to assess the stres experienced by caregivers. Results: The mean scores of ZBI were ranged from 24 to 83, with a mean of 47,64 ± 15,31. 68.6% (n = 72) of the caregivers were primary school graduates, 20% (n = 21) of secondary school graduates and 9.5% (n = 10) of higher education graduates. Only 1.9% (n = 2) were illiterate. 96.2% (n = 101) were married and 3,8% (n = 4) of single. When the professions of caregivers were examined, it was seen that 86.7% (n = 91) of them were housewives, followed b yteachers, government officials, nurses and self-employed people. When the age groups of caregivers according to the degree of careburden were examined, while 13 of the 21 caregivers over 40 years old (p= 0,001) and burdened severe, 14 of the 25 caregivers in the18-25 age group were burdened mild (p= 0,001). Income levels of caregivers were evaluated and 19 of the 41 patients with severe burden were found to have an income less than 1000 TL which was statistically significant (p= 0.004). The number of hospital visits revealed that; 33 of 34 patients with less than 5 per year hospital visit had a mildburden (p= 0.001) and 16 of 25 patients with more than 10 per year hospital visit had severe burden (p= 0.001). Conclusion: Determining caregiver burden of caregivers, identifying the difficulties they experience, providing necessary social and economic support, increasing quality of life is necessary for patients to receive beter quality services.