Primary Hyperparathyroidism: A Single-Center Experience

KIR, Seher; POLAT, Cafer

doi:10.5336/medsci.2019-66557

Primary Hyperparathyroidism: A Single-Center Experience

Seher KIR, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Samsun, Türkiye)

Cafer POLAT (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Samsun, Türkiye)

Türkiye Klinikleri Tıp Bilimleri Dergisi

1 0

Yıl: 2020 Cilt: 40 Sayı: 1 Sayfa Aralığı: 37 - 45 Metin Dili: İngilizce DOI: 10.5336/medsci.2019-66557 İndeks Tarihi: 23-10-2020

Primary Hyperparathyroidism: A Single-Center Experience

Öz:

Objective: Primary hyperparathyroidism (PHPT) ischaracterized by hypercalcemia and elevated parathyroid hormone(PTH) levels. In this study, we aimed to report our clinical experienceby presenting the demographic, laboratory, and clinical features ofour PHPT patients. Material and Methods: A total of 217 patientswho underwent parathyroidectomy from 2010 to 2018 at OndokuzMayıs University General Surgery Clinic were retrospectively reviewed, and PHPT patients who were diagnosed with parathyroid adenoma were further evaluated. Results: In total, 136 patients (85.3%females) with a mean age of 52.6±12.66 years were included. Theprevalence of osteoporosis, nephrolithiasis, hypercalciuria, and vitamin D deficiency were 45.3%, 21.7%, 59.0%, and 63.8%, respectively. Postoperative hypocalcemia (21.3%) was only related with lowpreoperative calcium levels (p=0.002). Preoperative calcium was positively correlated with age (p=0.029), parathyroid adenoma weight(PAW) (p=0.009), and preoperative PTH (p<0.001) and negativelycorrelated with 25(OH)D3 (p=0.048). Preoperative PTH was positively correlated with PAW (p=0.002) and negatively correlated with25(OH)D3 (p=0.009). There was no correlation between 25(OH)D3and PAW (p=0.063). Conclusion: In our region, the prevalences ofosteoporosis and nephrolithiasis were low, indicating moderate clinical presentation and early diagnosis of PHPT. Postoperative hypocalcemia was associated with lower preoperative calcium levels. Low25(OH)D3 levels were associated with high calcium and PTH but notwith PAW.

Anahtar Kelime:

Primer Hiperparatiroidi: Tek Merkez Sonuçları

Öz:

Amaç: Primer hiperparatiroidizm (PHPT), hiperkalsemi ve yüksek paratiroid hormonu (PTH) seviyeleri ile karakterizedir. Bu çalışma ile PHPT hastalarımızın demografik, laboratuar ve klinik özelliklerini sunarak klinik deneyimimizi bildirmeyi amaçladık. Gereç ve Yöntemler: Ondokuz Mayıs Üniversitesi Genel Cerrahi Kliniği’nde 2010’dan 2018’e kadar paratiroidektomi yapılan toplam 217 hasta retrospektif olarak incelendi ve paratiroid adenomu tanısı alan PHPT hastaları ayrıntılı olarak değerlendirildi. Bulgular: Çalışmaya ortalama yaşı 52,6±12,66 yıl olan 136 hasta (%85,3 kadın) alındı. Osteoporoz, nefrolitiazis, hiperkalsiüri ve D vitamini eksikliği prevalansı sırasıyla %45,3, %21,7, %59,0 ve %63,8 idi. Postoperatif hipokalsemi (%21,3) sadece preoperatif düşük kalsiyum düzeyleri ile ilişkiliydi (p=0,002). Preoperatif kalsiyumun yaş (p=0,029), paratiroid adenom ağırlığı (parathyroid adenoma weight-PAW) (p=0,009) ve preoperatif PTH (p <0,001) ile pozitif, 25 (OH) D3 (p=0,048) ile negatif korelasyon gösterdiği bulundu. Preoperatif PTH, PAW (p=0,002) ile pozitif, 25 (OH) D3 (p=0,009) ile negatif korelasyon gösterdi. 25 (OH) D3 ve PAW arasında korelasyon yoktu (p=0,063). Sonuç: Bölgemizde orta derecede klinik prezentasyon ve erken dönemde PHPT tanısı konulmasını işaret edecek şekilde osteoporoz ve nefrolitiazis prevalansı düşüktü. Postoperatif hipokalsemi gelişimi düşük preoperatif kalsiyum düzeyi ile ilişkili olarak bulundu. Düşük 25 (OH) D3 seviyeleri yüksek kalsiyum ve PTH ile ilişkiliydi, fakat PAW ile ilişkili değildi

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KIR S, POLAT C (2020). Primary Hyperparathyroidism: A Single-Center Experience. , 37 - 45. 10.5336/medsci.2019-66557
Chicago	KIR Seher,POLAT Cafer Primary Hyperparathyroidism: A Single-Center Experience. (2020): 37 - 45. 10.5336/medsci.2019-66557
MLA	KIR Seher,POLAT Cafer Primary Hyperparathyroidism: A Single-Center Experience. , 2020, ss.37 - 45. 10.5336/medsci.2019-66557
AMA	KIR S,POLAT C Primary Hyperparathyroidism: A Single-Center Experience. . 2020; 37 - 45. 10.5336/medsci.2019-66557
Vancouver	KIR S,POLAT C Primary Hyperparathyroidism: A Single-Center Experience. . 2020; 37 - 45. 10.5336/medsci.2019-66557
IEEE	KIR S,POLAT C "Primary Hyperparathyroidism: A Single-Center Experience." , ss.37 - 45, 2020. 10.5336/medsci.2019-66557
ISNAD	KIR, Seher - POLAT, Cafer. "Primary Hyperparathyroidism: A Single-Center Experience". (2020), 37-45. https://doi.org/10.5336/medsci.2019-66557

APA	KIR S, POLAT C (2020). Primary Hyperparathyroidism: A Single-Center Experience. Türkiye Klinikleri Tıp Bilimleri Dergisi, 40(1), 37 - 45. 10.5336/medsci.2019-66557
Chicago	KIR Seher,POLAT Cafer Primary Hyperparathyroidism: A Single-Center Experience. Türkiye Klinikleri Tıp Bilimleri Dergisi 40, no.1 (2020): 37 - 45. 10.5336/medsci.2019-66557
MLA	KIR Seher,POLAT Cafer Primary Hyperparathyroidism: A Single-Center Experience. Türkiye Klinikleri Tıp Bilimleri Dergisi, vol.40, no.1, 2020, ss.37 - 45. 10.5336/medsci.2019-66557
AMA	KIR S,POLAT C Primary Hyperparathyroidism: A Single-Center Experience. Türkiye Klinikleri Tıp Bilimleri Dergisi. 2020; 40(1): 37 - 45. 10.5336/medsci.2019-66557
Vancouver	KIR S,POLAT C Primary Hyperparathyroidism: A Single-Center Experience. Türkiye Klinikleri Tıp Bilimleri Dergisi. 2020; 40(1): 37 - 45. 10.5336/medsci.2019-66557
IEEE	KIR S,POLAT C "Primary Hyperparathyroidism: A Single-Center Experience." Türkiye Klinikleri Tıp Bilimleri Dergisi, 40, ss.37 - 45, 2020. 10.5336/medsci.2019-66557
ISNAD	KIR, Seher - POLAT, Cafer. "Primary Hyperparathyroidism: A Single-Center Experience". Türkiye Klinikleri Tıp Bilimleri Dergisi 40/1 (2020), 37-45. https://doi.org/10.5336/medsci.2019-66557