Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients

Ergin, Mustafa; Bilican, Gulden; Gok Oguz, Ebru; Aylı, Mehmet Deniz; sahin, hatice; Yayar, Ozlem; Kıvrakoğlu, Fatih; Kayhan, Sanem

doi:10.5455/annalsmedres.2019.10.639

Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients

Gulden BILICAN, (Sağlık Bilimleri Üniversitesi, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, Ankara, Türkiye)

Ebru GOK OGUZ, (Sağlık Bilimleri Üniversitesi, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, Ankara, Türkiye)

Özlem YAYAR, (Manisa Devlet Hastanesi, Nefroloji Kliniği, Manisa, Türkiye)

Mustafa ERGİN, (Sağlık Bilimleri Üniversitesi, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, Ankara, Türkiye)

Fatih KIVRAKOĞLU, (Sağlık Bilimleri Üniversitesi, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, Ankara, Türkiye)

Sanem OZTEKIN, (Sağlık Bilimleri Üniversitesi, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, Ankara, Türkiye)

Hatice SAHIN, (Sağlık Bilimleri Üniversitesi, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, Ankara, Türkiye)

Mehmet Deniz AYLI (Sağlık Bilimleri Üniversitesi, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, Ankara, Türkiye)

Annals of Medical Research

7 2

Yıl: 2020 Cilt: 27 Sayı: 3 Sayfa Aralığı: 895 - 902 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2019.10.639 İndeks Tarihi: 23-10-2020

Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients

Öz:

Aim: Hemodialysis patients should have an access to a vessel. Thrombosis is responsible for 80-85% of fistula losses. Mean PlateletVolume (MPV) is routinely measured in complete blood count and shows the average volume of circulating platelets. In our study, weaimed to investigate whether MPV values may be used as a cheap and noninvasive marker in the early diagnosis and intervention ofarteriovenous fistula (AVF) thrombosis.Material and Methods: This retrospective study included 48 patients having one or more episodes of late fistula thrombosis at thehemodialysis unit and 47 patients without history of AVF thrombosis.Results: Demographic and laboratory characteristics were used to compare between groups and no significant difference was found(p> 0.05). On the other hand, significant difference was reported (p=0.001) by the comparison of two groups. Logistic regressionanalysis, revealed that MPV was an independent risk predictor for the development of AVF thrombosis (p <0.05).Conclusion: AVF dysfunction leads to a significant cost and frequent hospitalization of the patient. Previously, MPV was stated tobe a risk factor for arterial and venous thrombosis. This study showed that MPV values may be used in hemodialysis patients asa predictor of thrombosis. Further prospective and retrospective studies should be conducted in order to verify the finding of thisstudy.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Pastan S, Bailey J. Medical progress: dialysis therapy. The New England J Med 1998;338:1428-37.
2. Yan Y, Ye D, Yang L, et al. A meta-analysis of the association between diabetic patients and AVF failure in dialysis. Ren Fail 2018;40:379-83.
3. Yilmaz H, Bozkurt A, Cakmak M, et al. Relationship between late arteriovenous fistula (AVF) stenosis and neutrophil-lymphocyte ratio (NLR) in chronic hemodialysis patients. Ren Fail 2014;36:1390-4.
4. Allon M, Robbin ML. Robbin, Increasing arteriovenous fistulas in hemodialysis patients: problems and solutions. Kidney Int 2002;62:1109-24.
5. Hoffmann JJ. Reference range of mean platelet volume.Thromb Res 2012;129:534-5.
6. Park Y, Schoene N, Harris W. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets 2002;13:301-6.
7. Hekimsoy Z, Payzin B, Ornek T, et al. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18:173-6.
8. Yilmaz MB, Cihan G, Guray Y, et al. Role of mean platelet volume in triagging acute coronary syndromes. J Thromb Thrombolysis 2008;26:49-54.
9. Kostrubiec M, Łabyk A, Pedowska-Włoszek J, et al. Mean platelet volume predicts early death in acute pulmonary embolism. Heart 2010;96:460-5.
10. Mayda-Domaç F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebro Vasc Dis 2010;19:66-72.
11. Palatinus A, Adams M. Thrombosis in systemic lupus erythematosus.Semin Thromb Hemost 2009;35:621- 29.
12. Sakallı H, Kal O. Mean platelet volume as a potential predictor of proteinuria and amyloidosis in familial Mediterranean fever. Clin Rheumato 2013;32:1185- 90.
13. Acikgoz N, Karincaoglu Y, Ermis N, et al. Increased mean platelet volume in Behçet's disease with thrombotic tendency. Tohoku J Exp Med 2010;221:119-23.
14. Hayashi R, Huang E, Nissenson AR. Vascular access for hemodialysis. Nat Clin Pract Nephrol 2006;2:504- 13.
15. Lutz J, Menke J, Sollinger D, et al.Haemostasis in chronic kidney disease. Nephrol Dial Transplant 2014;29:29-40.
16. Glorieux G, Cohen G, Jankowski J, et al. Platelet/ Leukocyte activation, inflammation, and uremia. Semin Dial 2009;22:423-27.
17. Chronic Kidney Disease Prognosis Consortium, Matsushita K, van der Velde M, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet 2010;375:2073-81.
18. Wattanakit K, Cushman M, Stehman-Breen C, et al. Chronic kidney disease increases risk for venous thromboembolism. J Am Soc Nephrol 2008;19:135- 40.
19. Ishii T, Suziki Y, Nakayama T, et al. Duplex ultrasound fort the prediction of vascular events associated with arteriovenous fistulas in hemodialysis patients. J Vasc Access 2016;17:499-505.
20. Ravani P, Quinn RR, Oliver MJ, et al. Preemptive Correction of Arteriovenous Access Stenosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Am J Kidney Dis 2016;67:446-60.
21. Briggs C, Harrison P, Machin SJ. Continuing developments with the automated platelet count. Int J Lab Hematol 2007;29:77-91.
22. Bilen Y, Cankaya E, Keles M, et al.Does decreased mean platelet volume predict inflammation in chronic renal failure, dialysis, and transplanted patients? Ren Fail 2014; 36:69-72.
23. Gulcan M, Varol E, Etli M, et al. Mean platelet volume is increased in patients with deep vein thrombosis. Clinicaland Applied Thrombosis/Hemostasis 2012 ;18:427-30.
24. Kim S, Molnar MZ, Fonarow GC, et al. Mean platelet volume and mortality risk in a national incident hemodialysis cohort. Int J Cardiol 2016;220:862-70.
25. Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010;8:148-56.
26. Kisacik B, Tufan A, Kalyoncu U, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75:291-4.
27. Ricart JM, España F, Navarro S, et al.Mean platelet volume does not seem to relate to thrombosis or posterior uveitis in Behçet's disease. Clin Hemorheol Microcirc 2013;54:51-7.
28. Ju HY, Kim JK, Hur SM, et al. Could mean platelet volume be a promising biomarker of progression of chronic kidney disease? Platelets 2015;26:143-7.
29. Mahmoud Rafieian-Kopaie, Hamid Nasri. Platelet counts and mean platelet volume in association with serum magnesium in maintenance hemodialysis patients. J Renal Inj Prev 2012;1:17-21.
30. Bath PM, Saggar-Malik AK, Macdougall IC, et al. Increased platelet volume in patients with adult polycystic kidney disease. Platelets 1995;6:336-39.
31. Sakallı H, Baskın E, Bayrakçı US, et al. Mean Platelet Volume as a Potential Predictor of Renovascular Thrombosis After Renal Transplant. Exp Clin Transplant 2013;11:27-31.
32. Bath PM, Missouris CG, Buckenham T, et al. Increased platelet volume and platelet mass in patients with atherosclerotic renal artery stenosis. Clin Sci (Lond) 1994;87:253-7.
33. Cho A, Choi MJ, Lee YK, et al. Effects of aspirin resistance and mean platelet volume on vascular access failure in hemodialysis patients. Korean J Intern. 2019;34:1304-12.
34. Lano G, Sallée M, Pelletier M, et al. Mean Platelet Volume Predicts Vascular Access Events in Hemodialysis Patients. J Clin Med 2019;8.
35. Shin DH, Rhee SY, Jeon HJ, et al. An Increase in Mean Platelet Volume/Platelet Count Ratio Is Associated with Vascular Access Failure in Hemodialysis Patients. PLoS One 2017;12:0170357.

APA	Bilican G, Gok Oguz E, Yayar O, Ergin M, Kıvrakoğlu F, Kayhan S, sahin h, Aylı M (2020). Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients. , 895 - 902. 10.5455/annalsmedres.2019.10.639
Chicago	Bilican Gulden,Gok Oguz Ebru,Yayar Ozlem,Ergin Mustafa,Kıvrakoğlu Fatih,Kayhan Sanem,sahin hatice,Aylı Mehmet Deniz Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients. (2020): 895 - 902. 10.5455/annalsmedres.2019.10.639
MLA	Bilican Gulden,Gok Oguz Ebru,Yayar Ozlem,Ergin Mustafa,Kıvrakoğlu Fatih,Kayhan Sanem,sahin hatice,Aylı Mehmet Deniz Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients. , 2020, ss.895 - 902. 10.5455/annalsmedres.2019.10.639
AMA	Bilican G,Gok Oguz E,Yayar O,Ergin M,Kıvrakoğlu F,Kayhan S,sahin h,Aylı M Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients. . 2020; 895 - 902. 10.5455/annalsmedres.2019.10.639
Vancouver	Bilican G,Gok Oguz E,Yayar O,Ergin M,Kıvrakoğlu F,Kayhan S,sahin h,Aylı M Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients. . 2020; 895 - 902. 10.5455/annalsmedres.2019.10.639
IEEE	Bilican G,Gok Oguz E,Yayar O,Ergin M,Kıvrakoğlu F,Kayhan S,sahin h,Aylı M "Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients." , ss.895 - 902, 2020. 10.5455/annalsmedres.2019.10.639
ISNAD	Bilican, Gulden vd. "Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients". (2020), 895-902. https://doi.org/10.5455/annalsmedres.2019.10.639

APA	Bilican G, Gok Oguz E, Yayar O, Ergin M, Kıvrakoğlu F, Kayhan S, sahin h, Aylı M (2020). Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients. Annals of Medical Research, 27(3), 895 - 902. 10.5455/annalsmedres.2019.10.639
Chicago	Bilican Gulden,Gok Oguz Ebru,Yayar Ozlem,Ergin Mustafa,Kıvrakoğlu Fatih,Kayhan Sanem,sahin hatice,Aylı Mehmet Deniz Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients. Annals of Medical Research 27, no.3 (2020): 895 - 902. 10.5455/annalsmedres.2019.10.639
MLA	Bilican Gulden,Gok Oguz Ebru,Yayar Ozlem,Ergin Mustafa,Kıvrakoğlu Fatih,Kayhan Sanem,sahin hatice,Aylı Mehmet Deniz Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients. Annals of Medical Research, vol.27, no.3, 2020, ss.895 - 902. 10.5455/annalsmedres.2019.10.639
AMA	Bilican G,Gok Oguz E,Yayar O,Ergin M,Kıvrakoğlu F,Kayhan S,sahin h,Aylı M Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients. Annals of Medical Research. 2020; 27(3): 895 - 902. 10.5455/annalsmedres.2019.10.639
Vancouver	Bilican G,Gok Oguz E,Yayar O,Ergin M,Kıvrakoğlu F,Kayhan S,sahin h,Aylı M Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients. Annals of Medical Research. 2020; 27(3): 895 - 902. 10.5455/annalsmedres.2019.10.639
IEEE	Bilican G,Gok Oguz E,Yayar O,Ergin M,Kıvrakoğlu F,Kayhan S,sahin h,Aylı M "Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients." Annals of Medical Research, 27, ss.895 - 902, 2020. 10.5455/annalsmedres.2019.10.639
ISNAD	Bilican, Gulden vd. "Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients". Annals of Medical Research 27/3 (2020), 895-902. https://doi.org/10.5455/annalsmedres.2019.10.639