TY  - JOUR
TI  - The effects of genetic polymorphisms and diabetes mellitus on the development of peripheral artery disease
AB  - Objective: Peripheral artery disease (PAD) is a conditioncaused by the narrowing of limb arteries due to atherosclerosis. In recent years, polymorphisms in a number of geneshave been shown to contribute to the risk of PAD development.However, whether the contribution of these inheritable factorsis independent of traditional cardiovascular risk factors remainsunclear. This study was an investigation of the effects of diabetes mellitus (DM) and genetic background, examined singlyand together, on the pathogenesis of PAD.Methods: The effects of the factor V Leiden (G1691A), factorV H1299R, prothrombin G20210A, factor XIII V34L, B-firinogen -455 G>A, PAI-1 4G/5G, HPA1, MTHFR C677T, MTHFRA1298C, ACE I/D, APO B R3500Q, and APOE polymorphismswere evaluated using a cardiovascular disease strip assay(CVD StripAssay). Two groups were created: 100 patients withPAD (50 with DM, 50 without DM) and 60 controls without PAD(30 with DM, 30 without DM).Results: There was a signifiantly greater presence of theMTHFR A1298C and PAI 4G/5G homozygous polymorphismsin the PAD patients compared with the control group (p=0.035,p=0.004, respectively). There were no signifiant associationsbetween the other genotypes and polymorphism frequencies.In the presence of DM, the PAI-1 4G/5G homozygous polymorphism was linked to the formation of PAD (p=0.021). Regression analysis indicated that the PAI-1 4G/5G gene homozygous polymorphism demonstrated a 17.1 times greater risk forDM with PAD [95% confience interval (CI): 2.113-138.660;p=0.008] and the MTHFR A1298C homozygous polymorphismdemonstrated a 316.6 times greater risk (95% CI: 10.763-9315.342; p<0.001) for the possibility of DM with PAD.Conclusion: The MTHFR A1298C and PAI 4G/5G homozygouspolymorphisms may be associated with the development of PAD.The presence of the PAI 4G/5G homozygous polymorphism withDM was a powerful predictor for the development of PAD
AU  - YALIM, Zafer
AU  - Tutgun Onrat, Serap
AU  - Avsar, Alaettin
AU  - ALDEMİR, Mustafa Tayfun
AU  - YALIM, Sümeyra Alan
AU  - DOĞAN, İsmet
AU  - Onrat, Ersel
DO  - 10.5543/tkda.2020.15686
PY  - 2020
JO  - Türk Kardiyoloji Derneği Arşivi
VL  - 48
IS  - 5
SN  - 1016-5169
SP  - 484
EP  - 493
DB  - TRDizin
UR  - http://search/yayin/detay/368840
ER  -