TY  - JOUR
TI  - What We Learned about COVID-19 So Far? Notes from Underground
AB  - The novel coronavirus pandemic poses a major global threat to public health. Our knowledge concerning every aspect of COVID-19is evolving rapidly, given the increasing data from all over the world. In this narrative review, the Turkish Thoracic Society Early CareerTaskforce members aimed to provide a summary on recent literature regarding epidemiology, clinical findings, diagnosis, treatment,prevention, and control of COVID-19. Studies revealed that the genetic sequence of the novel coronavirus showed significant identityto SARS-CoV and MERS-CoV. Angiotensin-converting enzyme 2 receptor is an important target of the SARS-CoV-2 while entering anorganism. Smokers were more likely to develop the disease and have a higher risk for ICU admission. The mean incubation periodwas 6.4 days, whereas asymptomatic transmission was reported up to 25 days after infection. Fever and cough were the most commonsymptoms, and cardiovascular diseases and hypertension were reported to be the most common comorbidities among patients. Clinicalmanifestations range from asymptomatic and mild disease to severe acute respiratory distress syndrome. Several patients showed typicalsymptoms and radiological changes with negative RT-PCR but positive IgG and IgM antibodies. Although radiological findings may vary,bilateral, peripherally distributed, ground-glass opacities were typical of COVID-19. Poor prognosis was associated with older age, higherSequential Organ Failure Assessment score, and high D-dimer level. Chloroquine was found to be effective in reducing viral replicationin vitro. Likewise, protease inhibitors, including lopinavir/ritonavir, favipiravir, and nucleoside analogue remdesivir were proposed to bethe potential drug candidates in COVID-19 management. Despite these efforts, we still have much to learn regarding the transmission,treatment, and prevention of COVID-19
AU  - Özakıncı, Hilal
AU  - Kaya, Ilknur
AU  - Esendagli, Dorina
AU  - Ataoğlu, Özlem
AU  - Yildiz Gulhan, Pinar
AU  - Erçelik, Merve
AU  - Ramasli Gursoy, Tugba
AU  - Sertçelik, Ümran
AU  - marım, feride
AU  - POLAT, DEMET
AU  - Gurz, Selcuk
AU  - Yılmaz Kara, Bilge
AU  - YÜKSEL, AYCAN
AU  - Günaydın, Fatma Esra
AU  - Tokgoz Akyil, Fatma
AU  - ÇELİK, selma
AU  - Serifoglu, Irem
AU  - Asena, Aydin
AU  - KILINÇ, MUKADDES
AU  - Akgün, Metin
AU  - Er, Berrin
AU  - Gunduz Gurkan, Canan
AU  - Karaoğlanoğlu, Selen
AU  - Karadoğan, Dilek
AU  - Develi, Elif
AU  - Arikan, Huseyin
AU  - Emiralioglu, Nagehan
AU  - Çiftçi Küsbeci, Tuba
AU  - karcıoğlu, oğuz
AU  - Çakmakcı Karakaya, Selin
AU  - ÖNYILMAZ, ASLI
AU  - Kızılırmak, Deniz
AU  - Er, Aslıhan Banu
AU  - Toptay, Hüseyin
AU  - TOREYIN, NUR
AU  - Sismanlar Eyuboglu, Tugba
DO  - 10.5152/TurkThoracJ.2020.20052
PY  - 2020
JO  - Turkish Thoracic Journal
VL  - 21
IS  - 3
SN  - 2149-2530
SP  - 185
EP  - 192
DB  - TRDizin
UR  - http://search/yayin/detay/370759
ER  -