Yıl: 2019 Cilt: 14 Sayı: 3 Sayfa Aralığı: 140 - 144 Metin Dili: İngilizce

Changes in Corneal Biomechanical Properties Following Hemodialysis in Non-Diabetic End Stage Renal Disease

Öz:
Purpose: The aim of this study was to evaluate changes in corneal biomechanical properties following hemodialysis using an ocular responseanalyzer (ORA) in non-diabetic end stage renal diseaseMaterials and Methods: We included one eye of 50 non-diabetic chronic renal failure patients (25 females and 25 males) with a mean age of56.94 ± 9.95 years (range 36-80 years) in this cross-sectional study. Corneal compensated intraocular pressure (IOPcc), corneal hysteresis (CH)and the corneal resistance factor (CRF) were measured for included the eye of each participant using an ORA before and after hemodialysis.Central corneal thickness (CCT), blood pressure, plasma osmolality and plasma colloid osmotic pressure were also measured before and afterthe hemodialysis session. A paired samples t-test and Pearson’s correlation analysis were carried out for statistical analysis.Results: The mean CCT, IOPcc, CH and CRF of the patients before hemodialysis were 550.20±19.64 μm, 16.84±3.20 mmHg, 10.68±2.41mmHg and 11.36±2.50 mmHg, respectively. The mean CCT, IOPcc, CH and CRF of the patients after hemodialysis were 547.30±19.83 μm,15.61±2.77 mmHg, 11.38±2.91 mmHg and 11.37±2.96 mmHg, respectively. The mean plasma osmolality, plasma colloid oncotic pressure andmean arterial pressure (MAP) of the patients before hemodialysis were 309.12±9.10 mOsm/L, 23.86±1.49 mmHg and 99.74±12.84 mmHg,respectively. The mean plasma osmolality, plasma colloid oncotic pressure and mean arterial pressure (MAP) of the patients after hemodialysiswere 293.74±8.82 mOsm/L, 28.72±2.19 mmHg and 87.53±10.98 mmHg, respectively. Signifi cant changes occurred in IOPcc, CH, meanarterial pressure, serum osmolality and plasma colloid oncotic pressure (p values of 0.006, 0.036, <0.001, <0.001 and <0.001, respectively).There was no signifi cant difference in the CRF or CCT values before and after hemodialysis (p values of 0.980 and 0.084, respectively). Therewere signifi cant moderate correlations between differences in IOPcc and CH (r=-0.369, p=0.008) and MAP and CH (r=0.355, p=0.011).Conclusion: Hemodialysis did not alter CCT and CRF but caused a signifi cant IOP decrease and CH increase in non-diabetic chronic renalfailure patients that need be taken into account during the evaluation of IOP in hemodialysis patients.
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Diyabetik Olmayan Son Dönem Böbrek Hastalığında Hemodiyaliz Sonrası Kornea Biyomekanik Özelliklerinde Görülen Değişiklikler

Öz:
Amaç: Diyabetik olmayan son dönem böbrek yetmezliği olan hastalarda oküler cevap analizörü kullanarak (OCA) hemodiyalizi takiben korneanın biyomekanik özelliklerinde görülen değişimleri değerlendirmek Gereç ve Yöntem: Bu kesitsel çalışmaya ortalama yaşları 56.94 ± 9.95 yıl olan 50 diyabetik olmayan kronik böbrek yetmezliği olan hastanın (25 erkek ve 25 kadın) tek gözleri dahil edildi. Korneal kompanse göz içi basıncı (GİBkk), korneal histerezis (KH) ve korneal direnç faktör (KDF) hemodiyaliz öncesi ve sonrası OCA kullanılarak ölçüldü. Aynı zamanda santral korneal kalınlık (SKK), kan basıncı, plazma osmolalitesi ve plazma kolloid onkotik basınç hemodiyaliz öncesi ve sonrası ölçüldü. İstatiksel analiz için eşleştirilmiş örneklem t-testi ve Pearson korelasyon analizi kullanıldı. Bulgular: Hemodiyaliz öncesi hastaların ortalama SKK, GİBkk, KH ve KDF değerleri sırasıyla 550.20±19.64 μm, 16.84±3.20 mmHg, 10.68±2.41 mmHg ve 11.36±2.50 mmHg, hemodiyaliz sonrası hastaların ortalama SKK, GİBkk, KH ve KDF değerleri sırasıyla 547.30±19.83 μm, 15.61±2.77 mmHg, 11.38±2.91 mmHg ve 11.37±2.96 mmHg olarak ölçüldü. Hemodiyaliz öncesi hastaların ortalama plazma osmolalitesi, plazma kolloid onkotik basınç ve ortalama arteryel basınç (OAB) değerleri sırasıyla 309.12±9.10 mOsm/L, 23.86±1.49 mmHg ve 99.74±12.84 mmHg, hemodiyaliz sonrası hastaların ortalama plazma osmolalitesi, plazma kolloid onkotik basınç ve OAB değerleri sırasıyla 293.74±8.82 mOsm/L, 28.72±2.19 mmHg ve 87.53±10.98 mmHg olarak ölçüldü. GİBkk, KH, OAB, plazma osmolalitesi ve plazma kolloid onkotik basınçta önemli değişiklikler meydana geldi. (p değerleri sırasıyla, 0.006, 0.036, <0.001, <0.001 ve <0.001). Hemodiyaliz öncesi ve sonrası KDF ve SKK değerleri arasında önemli bir fark yoktu. (p değerleri sırasıyla, 0.980 ve 0.084). GİBkk ve KH (r=-0.369, p=0.008) ve OAB ve KH (r=0.355, p=0.011) arasında önemli orta derecede ilişki mevcuttu. Sonuç: Hemodiyaliz, GİB değerlendirilmesinde dikkate alınması gereken diyabetik olmayan son dönem kronik böbrek yetmezliği olan hemodiyaliz hastalarında SKK ve KDF’de değişikliğe neden olmamaktadır fakat önemli derecede GİBkk’da azalma, KH’de artışa sebep olmaktadır.
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
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APA BALBABA M, ULAŞ F, EVREN Ö, YİĞİT İ (2019). Changes in Corneal Biomechanical Properties Following Hemodialysis in Non-Diabetic End Stage Renal Disease. Glokom Katarakt, 14(3), 140 - 144.
Chicago BALBABA Mehmet,ULAŞ Fatih,EVREN Özge,YİĞİT İrem Pembegül Changes in Corneal Biomechanical Properties Following Hemodialysis in Non-Diabetic End Stage Renal Disease. Glokom Katarakt 14, no.3 (2019): 140 - 144.
MLA BALBABA Mehmet,ULAŞ Fatih,EVREN Özge,YİĞİT İrem Pembegül Changes in Corneal Biomechanical Properties Following Hemodialysis in Non-Diabetic End Stage Renal Disease. Glokom Katarakt, vol.14, no.3, 2019, ss.140 - 144.
AMA BALBABA M,ULAŞ F,EVREN Ö,YİĞİT İ Changes in Corneal Biomechanical Properties Following Hemodialysis in Non-Diabetic End Stage Renal Disease. Glokom Katarakt. 2019; 14(3): 140 - 144.
Vancouver BALBABA M,ULAŞ F,EVREN Ö,YİĞİT İ Changes in Corneal Biomechanical Properties Following Hemodialysis in Non-Diabetic End Stage Renal Disease. Glokom Katarakt. 2019; 14(3): 140 - 144.
IEEE BALBABA M,ULAŞ F,EVREN Ö,YİĞİT İ "Changes in Corneal Biomechanical Properties Following Hemodialysis in Non-Diabetic End Stage Renal Disease." Glokom Katarakt, 14, ss.140 - 144, 2019.
ISNAD BALBABA, Mehmet vd. "Changes in Corneal Biomechanical Properties Following Hemodialysis in Non-Diabetic End Stage Renal Disease". Glokom Katarakt 14/3 (2019), 140-144.