The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury

Cebrail AKYÜZ, (Haydarpaşa Numune Eğitim ve Araştırma Hastanesi,Gastroenterolojik Cerrahi ve Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye.)
Orhan UZUN, (Kartal Koşuyolu Eğitim ve Araştırma Hastanesi,Gastroenterolojik Cerrahi Anabilim Dalı,İstanbul, Türkiye.)
Oguzhan SUNAMAK, (Haydarpaşa Numune Eğitim ve Araştırma Hastanesi ,Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye.)
Ayliz VELİOĞLU-ÖĞÜNÇ, (Marmara Üniversitesi ,Sağlık Meslek Yüksekokulu, İstanbul, Türkiye)
Şule ÇETİNEL, (Marmara Üniversitesi, Tıp Fakültesi, Histoloji-Embriyoloji Anabilim Dalı,İstanbul, Türkiye.)
Ahmet Özer ŞEHİRLİ (Yakın Doğu Üniversitesi, Diş Hekimliği Fakültesi, Farmakoloji Anabilim Dalı,Lefkoşa, Kuzey Kıbrıs Türk Cumhuriyeti.)
Marmara Pharmaceutical Journal
5 0
Yıl: 2018 Cilt: 22 Sayı: 3 Sayfa Aralığı: 429 - 435 Metin Dili: İngilizce DOI: https://doi.org/10.12991/jrp.2018.83 İndeks Tarihi: 30-10-2020

The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury

Öz:
The aim of this study was to evaluate the possible protective effect of spironolactone (SPL) and role of the Na-K ATPase pump on intestinal ischemia/reperfusion injury. In our study, the period of ischemia was established by clamping the mesenteric artery for 45 minunder anesthesia in Wistar albino rats and the animals left for reperfusion at the end of this period were decapitated after one hour. Spironolactone (20 mg kg-1) was administered orally for three days before ischemia, 30 minbefore ischemia. The control group rats were subjected to the Sham operation and administered saline solution. TNF-α and IL-1β levels were measured in the serum samples. Ileal Na+/K+-ATPase, myeloperoxidase(MPO)analysiswereperformed.Structuralinjurywasassessedhistopathologically. Ischemia/reperfusion increased serum TNF-α and IL-1β levels together with MPO activity, whereas these values were maintained atthe control group levels through SPL activation. However, ischemia/reperfusion decreased Na+/K+-ATPase activity in ileal tissues; however, these parameters were found to be significantly increased with SPL activation. The protective effect of SPL against ischemia/reperfusion injury by different mechanisms, mainly the activity of the Na+/K+-ATPase pump, suggests that this nontoxic agent may constitute a new clinical therapeutic principle.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA akyüz c, UZUN O, SUNAMAK O, VELİOĞLU-ÖĞÜNÇ A, ÇETİNEL Ş, ŞEHİRLİ A (2018). The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury. , 429 - 435. https://doi.org/10.12991/jrp.2018.83
Chicago akyüz cebrail,UZUN Orhan,SUNAMAK Oguzhan,VELİOĞLU-ÖĞÜNÇ Ayliz,ÇETİNEL Şule,ŞEHİRLİ Ahmet ÖZER The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury. (2018): 429 - 435. https://doi.org/10.12991/jrp.2018.83
MLA akyüz cebrail,UZUN Orhan,SUNAMAK Oguzhan,VELİOĞLU-ÖĞÜNÇ Ayliz,ÇETİNEL Şule,ŞEHİRLİ Ahmet ÖZER The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury. , 2018, ss.429 - 435. https://doi.org/10.12991/jrp.2018.83
AMA akyüz c,UZUN O,SUNAMAK O,VELİOĞLU-ÖĞÜNÇ A,ÇETİNEL Ş,ŞEHİRLİ A The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury. . 2018; 429 - 435. https://doi.org/10.12991/jrp.2018.83
Vancouver akyüz c,UZUN O,SUNAMAK O,VELİOĞLU-ÖĞÜNÇ A,ÇETİNEL Ş,ŞEHİRLİ A The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury. . 2018; 429 - 435. https://doi.org/10.12991/jrp.2018.83
IEEE akyüz c,UZUN O,SUNAMAK O,VELİOĞLU-ÖĞÜNÇ A,ÇETİNEL Ş,ŞEHİRLİ A "The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury." , ss.429 - 435, 2018. https://doi.org/10.12991/jrp.2018.83
ISNAD akyüz, cebrail vd. "The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury". (2018), 429-435. https://doi.org/https://doi.org/10.12991/jrp.2018.83
APA akyüz c, UZUN O, SUNAMAK O, VELİOĞLU-ÖĞÜNÇ A, ÇETİNEL Ş, ŞEHİRLİ A (2018). The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury. Marmara Pharmaceutical Journal, 22(3), 429 - 435. https://doi.org/10.12991/jrp.2018.83
Chicago akyüz cebrail,UZUN Orhan,SUNAMAK Oguzhan,VELİOĞLU-ÖĞÜNÇ Ayliz,ÇETİNEL Şule,ŞEHİRLİ Ahmet ÖZER The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury. Marmara Pharmaceutical Journal 22, no.3 (2018): 429 - 435. https://doi.org/10.12991/jrp.2018.83
MLA akyüz cebrail,UZUN Orhan,SUNAMAK Oguzhan,VELİOĞLU-ÖĞÜNÇ Ayliz,ÇETİNEL Şule,ŞEHİRLİ Ahmet ÖZER The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury. Marmara Pharmaceutical Journal, vol.22, no.3, 2018, ss.429 - 435. https://doi.org/10.12991/jrp.2018.83
AMA akyüz c,UZUN O,SUNAMAK O,VELİOĞLU-ÖĞÜNÇ A,ÇETİNEL Ş,ŞEHİRLİ A The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury. Marmara Pharmaceutical Journal. 2018; 22(3): 429 - 435. https://doi.org/10.12991/jrp.2018.83
Vancouver akyüz c,UZUN O,SUNAMAK O,VELİOĞLU-ÖĞÜNÇ A,ÇETİNEL Ş,ŞEHİRLİ A The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury. Marmara Pharmaceutical Journal. 2018; 22(3): 429 - 435. https://doi.org/10.12991/jrp.2018.83
IEEE akyüz c,UZUN O,SUNAMAK O,VELİOĞLU-ÖĞÜNÇ A,ÇETİNEL Ş,ŞEHİRLİ A "The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury." Marmara Pharmaceutical Journal, 22, ss.429 - 435, 2018. https://doi.org/10.12991/jrp.2018.83
ISNAD akyüz, cebrail vd. "The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury". Marmara Pharmaceutical Journal 22/3 (2018), 429-435. https://doi.org/https://doi.org/10.12991/jrp.2018.83
Sayfa Oluşturulma Tarihi
23-04-2024 14:33

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