Objective: To examine the root apical morphology of human maxillary and mandibular first and second molars in the north-ern Anatolian population. Material and Methods: A total of 2140 human maxillary and mandibular first and second molars were in-vestigated using a computer-aided stereomicroscope with 80X mag-nification. The following observations were made: count of apical foramina, the shape and the widest and the narrowest diameters of apical foramina, accessory foramina frequency, the location of api-cal foramina on the root surface and the distance between the anatom-ical apex and apical foramina. Results: The most frequently observed shape among the minor apical foramina was oval. Both maxillary and mandibular molar roots had a maximum of two minor apical foram-ina. The mean narrowest and widest diameters of the apical foramina of all roots of maxillary molars ranged from 186.77 to 364.79 μm and 223.98 to 453.42 μm, respectively. The mean narrowest and widest di-ameters of the apical foramina of all roots of mandibular molars ranged from 178.79 to 309.20 μm and 209.79 to 419.55 μm, respec-tively. Frequency of accessory foramina ranged between 2.5% and 53.33% for the roots of maxillary molars, whereas the frequencies ranged from 14.29% to 44.12% for the roots of mandibular molars. The mean distance between the anatomical apex and apical foramina ranged from 357.88 to 626.391 μm for the roots of maxillary molars, while it ranged from 392.69 to 1126.36 μm for mandibular molars. Conclusion: The results of this study revealed that anatomic features of the root apical region are highly complex among the investigated population.