The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms
Yıl: 2020 Cilt: 28 Sayı: 2 Sayfa Aralığı: 315 - 321 Metin Dili: İngilizce DOI: 10.5606/tgkdc.dergisi.2020.18432 İndeks Tarihi: 31-10-2020
The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms
Öz: Background: This study aims to investigate the role of positron emissiontomography/computed tomography in differentiating between benignand malignant anterior mediastinal masses and between the histologicalsubtypes of thymic epithelial neoplasms.Methods: This retrospective study included a total of 57 patients(30 males, 27 females; mean age 48.9 years; range, 14 to 78 years)who underwent an fluorodeoxyglucose positron emission tomography/computed tomography with an indication of an anterior mediastinalmass between May 2010 and November 2018. The maximum andmean standardized uptake values, metabolic tumor volume, total lesionglycolysis, and mean Hounsfield units of the lesions were determined.Thymic epithelial neoplasms were classified as low-risk thymomas(A, AB, B1), high-risk thymomas (B2, B3), and thymic carcinomas.All lesions were evaluated together and divided into two groups asbenign and malignant, and positron emission tomography/computedtomography parameters of the two groups were compared.Results: Histopathological examination identified 29 thymic epithelialneoplasms (13 low-risk, 14 high-risk, two thymic carcinomas), 13 benignlesions, and 15 malignant lesions. No significant correlation was identifiedbetween the positron emission tomography/computed tomographyparameters and histological subtype of thymic epithelial neoplasms. Therewas no significant difference in the maximum and mean standardizeduptake values, metabolic tumor volume, total lesion glycolysis, and meanHounsfield units of the lesions between low-risk and high-risk thymiccarcinomas. The maximum and mean standardized uptake values,metabolic tumor volume, and mean Hounsfield units of the lesions weresignificantly higher in the malignant group than in the benign group.Conclusion: Our study results show that positron emission tomography/computed tomography is useful in the differentiation of benign andmalignant anterior mediastinal masses, although it fails to differentiatebetween the histological subtypes of thymic epithelial neoplasms.
Anahtar Kelime: Anterior mediastinal kitlelerin değerlendirilmesinde ve timik epitelyal neoplazilerin histolojik alt tip ayrımında pozitron emisyon tomografi/bilgisayarlı tomografinin rolü
Öz: Amaç: Bu çalışmada anterior mediastinal kitlelerin benign/ malign ayrımında ve timik epitelyal neoplazilerin histolojik alt tip ayrımında pozitron emisyon tomografi/bilgisayarlı tomografinin rolü araştırıldı. Çalışma planı: Bu retrospektif çalışmaya Mayıs 2010 - Kasım 2018 tarihleri arasında anterior mediastinal kitle endikasyonu ile florodeoksiglukoz pozitron emisyon tomografi/bilgisayarlı tomografi çekilen toplam 57 hasta (30 erkek, 27 kadın; ort. yaş 48.9 yıl; dağılım, 14-78 yıl) dahil edildi. Lezyonların maksimum ve ortalama standardize tutulum değerleri, metabolik tümör volümü, total lezyon glikolizi ve ortalama Hounsfield birimi belirlendi. Timik epitelyal neoplaziler düşük riskli timomalar (A, AB, B1), yüksek riskli timomalar (B2, B3) ve timik karsinomlar olmak üzere sınıflandırıldı. Tüm lezyonlar bir arada değerlendirildi, benign ve malign olmak üzere iki gruba ayrıldı ve bu iki grubun pozitron emisyon tomografi/bilgisayarlı tomografi parametreleri karşılaştırıldı. Bulgular: Histopatolojik incelemede 29 timik epitelyal neoplazi (13 düşük riskli, 14 yüksek riskli ve iki timik karsinom), 13 benign lezyon ve 15 malign lezyon saptandı. Pozitron emisyon tomografi/ bilgisayarlı tomografi parametreleri ve timik epitelyal neoplaziler arasında anlamlı bir ilişki tespit edilmedi. Düşük riskli ve yüksek riskli timik karsinomlar arasında maksimum ve ortalama standardize tutulum değerleri, metabolik tümör volümü, total lezyon glikolizi ve ortalama Hounsfield birimi açısından anlamlı bir fark yoktu. Lezyonların maksimum ve ortalama standardize tutulum değerleri, metabolik tümör volümü ve ortalama Hounsfield birimi benign gruba kıyasla malign grupta anlamlı düzeyde daha yüksekti. Sonuç: Çalışma sonuçlarımız, pozitron emisyon tomografi/bilgisayarlı tomografinin benign ve malign anterior mediastinal kitlelerin ayrımında kullanışlı olduğunu; ancak, timik epitelyal neoplazilerin histolojik alt tiplerinin ayrımında yetersiz kaldığını göstermektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | YANARATEŞ A, BUDAK E (2020). The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms. , 315 - 321. 10.5606/tgkdc.dergisi.2020.18432 |
| Chicago | YANARATEŞ AHMET,BUDAK EMİNE The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms. (2020): 315 - 321. 10.5606/tgkdc.dergisi.2020.18432 |
| MLA | YANARATEŞ AHMET,BUDAK EMİNE The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms. , 2020, ss.315 - 321. 10.5606/tgkdc.dergisi.2020.18432 |
| AMA | YANARATEŞ A,BUDAK E The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms. . 2020; 315 - 321. 10.5606/tgkdc.dergisi.2020.18432 |
| Vancouver | YANARATEŞ A,BUDAK E The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms. . 2020; 315 - 321. 10.5606/tgkdc.dergisi.2020.18432 |
| IEEE | YANARATEŞ A,BUDAK E "The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms." , ss.315 - 321, 2020. 10.5606/tgkdc.dergisi.2020.18432 |
| ISNAD | YANARATEŞ, AHMET - BUDAK, EMİNE. "The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms". (2020), 315-321. https://doi.org/10.5606/tgkdc.dergisi.2020.18432 |
| APA | YANARATEŞ A, BUDAK E (2020). The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms. Türk Göğüs Kalp Damar Cerrahisi Dergisi, 28(2), 315 - 321. 10.5606/tgkdc.dergisi.2020.18432 |
| Chicago | YANARATEŞ AHMET,BUDAK EMİNE The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms. Türk Göğüs Kalp Damar Cerrahisi Dergisi 28, no.2 (2020): 315 - 321. 10.5606/tgkdc.dergisi.2020.18432 |
| MLA | YANARATEŞ AHMET,BUDAK EMİNE The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms. Türk Göğüs Kalp Damar Cerrahisi Dergisi, vol.28, no.2, 2020, ss.315 - 321. 10.5606/tgkdc.dergisi.2020.18432 |
| AMA | YANARATEŞ A,BUDAK E The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2020; 28(2): 315 - 321. 10.5606/tgkdc.dergisi.2020.18432 |
| Vancouver | YANARATEŞ A,BUDAK E The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2020; 28(2): 315 - 321. 10.5606/tgkdc.dergisi.2020.18432 |
| IEEE | YANARATEŞ A,BUDAK E "The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms." Türk Göğüs Kalp Damar Cerrahisi Dergisi, 28, ss.315 - 321, 2020. 10.5606/tgkdc.dergisi.2020.18432 |
| ISNAD | YANARATEŞ, AHMET - BUDAK, EMİNE. "The role of positron emission tomography/computed tomography in the evaluation of anterior mediastinal masses and differentiating between the histological subtypes of thymic epithelial neoplasms". Türk Göğüs Kalp Damar Cerrahisi Dergisi 28/2 (2020), 315-321. https://doi.org/10.5606/tgkdc.dergisi.2020.18432 |
