Yıl: 2019 Cilt: 15 Sayı: 4 Sayfa Aralığı: 222 - 228 Metin Dili: İngilizce DOI: 10.5152/ejbh.2019.5032 İndeks Tarihi: 01-11-2020

Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast

Öz:
Objective: Thre are multiple subtypes of breast cancer with diffrent biological and pathological features and accordingly exhibit diffrent clinicalbehaviors. Th aim of this study was to compare the treatment modalities, clinical features and prognostic characteristics of Mix Mucinous Carcinomas (MMBC) and other rare tumors of the breast.Materials and Method: A total of 2152 patients who were operated on for breast cancer in our clinic between 2010-2019, with pathologicaldiagnoses of tubular, pure mucinous, mix mucinous or papillary carcinoma were enrolled in the study. Patients were divided into two groups as mixmucinous patients (Group1) and other rare tumors (Group2). Th demographic, clinical and prognostic characteristics and treatment approacheswere compared between Groups, and additionally between the subtypes of Group 2.Results: 42 patients participated in our study. Group 1 consisted of 7 patients, and Group2 consisted of 35 patients. Th subtypes in Group2 werepapillary (n=21), pure mucinous (n=10) and tubular (n=4). Progesterone Receptor Positivity was found to be signifiantly higher in Group 2 patientsthan in Group1 patients (p=0.005, p<0.05). Multicentricity rates in the tumors of the patients in Group1 were found to be statistically signifiantlyhigher than the patients in Group 2 (p=0.024, p<0.05). In subtype analysis in Group2, there were no statistically signifiant diffrences parametersin the subgroups (p>0.05). Mean survival was 19.5+5.6 (8.5-30.5) months in Group 1 and 46.3+5.2 (36.1-56.6) months, in Group2 when evaluated separately (p:0.002).Conclusion: Th prognosis of pure mucinosis (PMBC) and other atypical cancers of the breast compared to the (MMBC) is quite good. Rarepathological types of breast cancer can have favorable outcomes when treated with necessary oncological principles.
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  • 1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90. (PMID: 21296855) [CrossRef]
  • 2. Türkiye’de Kanser İstatistikleri. Available from: URL: https://hsgm. saglik.gov.tr/depo/birimler/kanser-db/istatistik/Turkiye_Kanser_Istatistikleri_2015.pdf (01.04.2019)
  • 3. Tavassoli FA, Devilee P. World Health Organization Classifiation of Tumors: Pathology and Genetics of Tumors of the Breast and Female Genital Organs. Lyon, France: IARC Press, 2003.
  • 4. Dieci MV, Orvieto E, Dominici M, Conte P, Guarneri V. Rare breast cancer subtypes: histological, molecular, and clinical peculiarities. Oncologist 2014; 19: 805-813. (PMID: 24969162) [CrossRef]
  • 5. Tan PH, Schnitt SJ, van de Vijver MJ, Ellis IO, Lakhani SR. Papillary and neuroendocrine breast lesions: the WHO stance. Histopathology 2015; 66: 761-770. (PMID: 24845113) [CrossRef]
  • 6. Louwman MW, Vriezen M, van Beek MW, Nolthenius-Puylaert MC, van der Sangen MJ, Roumen RM, Kiemeney LA, Coebergh JW. Uncommon breast tumors in perspective: Incidence, treatment and survival in the Netherlands. Int J Cancer 2007; 121: 127-135. (PMID: 17330844) [CrossRef]
  • 7. Rosen PP. Rosen’s breast pathology, 2nd ed. Philadelphia: LippincottWilliams & Wilkins, 2001: 365-380.
  • 8. Fentiman IS, Millis RR, Smith P, Ellul J Lampejo O. Mucoid breast carcinomas: histology and prognosis. Br J Cancer 1997; 75: 1061-1065. (PMID: 9083343) [CrossRef]
  • 9. Skotnicki P, Sas-Korczynska B, Strzepek L, Jakubowicz J, Blecharz P, Reinfuss M, Walasek T. Pure and mixed mucinous carcinoma of the breast: a comparison of clinical outcomes and treatment results. Breast J 2016; 22: 529-534. (PMID: 27261206) [CrossRef]
  • 10. Kashiwagi S, Onoda N, Asano Y, Noda S, Kawajiri H, Takashima T, Ohsawa M, Kitagawa S, Hirakawa K. Clinical signifiance of the subclassifiation of 71 cases mucinous breast carcinoma. Springerplus 2013; 2: 481-487. (PMID: 24156087) [CrossRef]
  • 11. Scopsi L, Andreola S, Pilotti S, Bufalino R, Baldini MT, Testori A, Rilke F. Mucinous carcinoma of the breast. A clinicopathologic, histochemical, and immunocytochemicalstudy with special reference to neuroendocrine diffrentiation. Am J Surg Pathol 1994; 18: 702-711. (PMID: 8017565) [CrossRef]
  • 12. Mendelson EB., Böhm-Vélez M, Berg WA, Whitman GJ, Feldman MI, Madjar H. ACR BI-RADS® Atlas, Breast Imaging Reporting and Data System. Reston, VA: American College of Radiology; 2013.
  • 13. EDGE, Stephen B. AJCC cancer staging manual. Springer, 2010, 7: 97- 100.
  • 14. Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol 1998; 11: 155-168. (PMID: 9504686)
  • 15. Shousha S. Oestrogen receptor status of breast carcinoma: Allred/H score conversion table. Histopathology 2008; 53: 346-347. (PMID: 18631198) [CrossRef]
  • 16. Dumitru A, Procop A, Iliesiu A, Tampa M, Mitrache L, Costache M, Sajin M, Lazaroiu A, Cirstoiu M. Mucinous breast cancer: a review study of 5 year experience from a hospital-based series of cases. Maedica 2015; 10: 14-18. (PMID: 26225144)
  • 17. Gündeş E, Aksoy F, Vatansev C, Çakır M. Pure and mixed mucinous carcinoma of the breast. J Breast Health 2013; 9: 182-185. [CrossRef]
  • 18. Tseng HS, Lin C, Chan SE, Chien SY, Kuo SJ, Chen ST, Chang TW, Chen DR. Pure mucinous carcinoma of the breast: clinicopathologic characteristics and long-term outcome among Taiwanese women. World J Surg Oncol 2013; 11: 139. (PMID: 23768133) [CrossRef]
  • 19. Vo T, Xing Y, Meric-Bernstam F, Mirza N, Vlastos G, Symmans WF, Perkins GH, Buchholz TA, Babiera GV, Kuerer HM, Bedrosian I, Akins JS, Hunt KK. Long-term outcomes in patients with mucinous, medullary, tubular, and invasive ductal carcinomas after lumpectomy. Am J Surg 2007; 194: 527-531. (PMID: 17826073) [CrossRef]
  • 20. Anan K, Mitsuyama S, Tamae K, Nishihara K, Iwashita T, Abe Y, Ihara T, Nakahara S, Katsumoto F, Toyoshima S. Pathological features of mucinous carcinoma of the breast are favourable for breast-conserving therapy. Eur J Surg Oncol 2001; 27: 459-463. (PMID: 11504516) [CrossRef]
  • 21. Andre S, Cunha F, Bernardo M, Meneses e Sousa J, Cortez F, Soares J. Mucinous carcinoma of the breast: a pathologic study of 82 cases. J Surg Oncol 1995; 58: 162-167. (PMID: 7898111) [CrossRef]
  • 22. Deos PH, Norris HJ. Well-diffrentiated (tubular) carcinoma of the breast. A clinicopathologic study of 145 pure and mixed cases. Am J Clin Pathol 1982; 78: 1-7. (PMID: 6285690) [CrossRef]
  • 23. Shin HJ, Kim HH, Kim SM, Kim DB, Lee YR, Kim MJ, Gong G. Pure and mixed tubular carcinoma of the breast: mammographic and sonographic diffrential features. Korean J Radiol 2007; 8: 103-110. (PMID: 17420627) [CrossRef]
  • 24. Zheng Y, Hu X, Shao Z. Clinicopathological characteristics and survival outcomes in invasive papillary carcinoma of the breast: a SEER population-based study. Sci Rep 2016; 6: 24-37. (PMID: 27053333) [CrossRef]
  • 25. Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thrlimann B, Senn HJ. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Thrapy of Early Breast Cancer 2013. Ann Oncol 2003; 24: 2206-2223. (PMID: 23917950)
  • 26. Nakagawa T, Sato K, Moriwaki M, Wada R, Arakawa A, Saito M, Kasumi F. Successful endocrine therapy for locally advanced mucinous carcinoma of the breast. Breast J 2012; 18: 632-633. (PMID: 23110390) [CrossRef]
  • 27. Di Saverio S, Gutierrez J, Avisar E. A retrospective review with long term follow up of 11,400 cases of pure mucinous breast carcinoma. Breast Cancer Res Treat 2008; 111: 541-547. (PMID: 18026874) [CrossRef]
  • 28. Toikkanen S, Kujari H. Pure and mixed mucinous carcinomas of the breast: a clinicopathologic analysis of 61 cases with long-term follow-up. Hum Pathol 1989; 20: 758-764. (PMID: 2545592) [CrossRef]
  • 29. Chaudhry AR, El Khoury M, Gotra A, Eslami Z, Omeroglu A, Omeroglu-Altinel G, Chaudhry SH, Mesurolle B. Imaging features of pure and mixed forms of mucinous breast carcinoma with histopathological correlation. Br J Radiol 2019; 92: 20180810. (PMID: 30632779) [CrossRef]
APA gök m, topal u, ÖZ B, AKGÜN H, AKCAN A, Sözüer E (2019). Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast. , 222 - 228. 10.5152/ejbh.2019.5032
Chicago gök mustafa,topal uğur,ÖZ Bahadır,AKGÜN HÜLYA,AKCAN ALPER CELAL,Sözüer Erdoğan Mütevelli Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast. (2019): 222 - 228. 10.5152/ejbh.2019.5032
MLA gök mustafa,topal uğur,ÖZ Bahadır,AKGÜN HÜLYA,AKCAN ALPER CELAL,Sözüer Erdoğan Mütevelli Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast. , 2019, ss.222 - 228. 10.5152/ejbh.2019.5032
AMA gök m,topal u,ÖZ B,AKGÜN H,AKCAN A,Sözüer E Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast. . 2019; 222 - 228. 10.5152/ejbh.2019.5032
Vancouver gök m,topal u,ÖZ B,AKGÜN H,AKCAN A,Sözüer E Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast. . 2019; 222 - 228. 10.5152/ejbh.2019.5032
IEEE gök m,topal u,ÖZ B,AKGÜN H,AKCAN A,Sözüer E "Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast." , ss.222 - 228, 2019. 10.5152/ejbh.2019.5032
ISNAD gök, mustafa vd. "Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast". (2019), 222-228. https://doi.org/10.5152/ejbh.2019.5032
APA gök m, topal u, ÖZ B, AKGÜN H, AKCAN A, Sözüer E (2019). Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast. European Journal of Breast Health, 15(4), 222 - 228. 10.5152/ejbh.2019.5032
Chicago gök mustafa,topal uğur,ÖZ Bahadır,AKGÜN HÜLYA,AKCAN ALPER CELAL,Sözüer Erdoğan Mütevelli Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast. European Journal of Breast Health 15, no.4 (2019): 222 - 228. 10.5152/ejbh.2019.5032
MLA gök mustafa,topal uğur,ÖZ Bahadır,AKGÜN HÜLYA,AKCAN ALPER CELAL,Sözüer Erdoğan Mütevelli Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast. European Journal of Breast Health, vol.15, no.4, 2019, ss.222 - 228. 10.5152/ejbh.2019.5032
AMA gök m,topal u,ÖZ B,AKGÜN H,AKCAN A,Sözüer E Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast. European Journal of Breast Health. 2019; 15(4): 222 - 228. 10.5152/ejbh.2019.5032
Vancouver gök m,topal u,ÖZ B,AKGÜN H,AKCAN A,Sözüer E Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast. European Journal of Breast Health. 2019; 15(4): 222 - 228. 10.5152/ejbh.2019.5032
IEEE gök m,topal u,ÖZ B,AKGÜN H,AKCAN A,Sözüer E "Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast." European Journal of Breast Health, 15, ss.222 - 228, 2019. 10.5152/ejbh.2019.5032
ISNAD gök, mustafa vd. "Comparison of Clinical Features and Treatment Results of Mix Mucinous Carcinomas and Other Atypical Carcinomas of the Breast". European Journal of Breast Health 15/4 (2019), 222-228. https://doi.org/10.5152/ejbh.2019.5032