Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments

öztürk, bilgin; karadaş, ömer

doi:10.29399/npa.21650

Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments

Bilgin ÖZTÜRK, (Gülhane Eğitim ve Araştırma Hastanesi, Nöroloji Kliniği, Ankara, Türkiye)

Ömer KARADAŞ (Gülhane Eğitim ve Araştırma Hastanesi, Nöroloji Kliniği, Ankara, Türkiye)

Nöropsikiyatri Arşivi

2 0

Yıl: 2020 Cilt: 57 Sayı: 3 Sayfa Aralığı: 192 - 196 Metin Dili: İngilizce DOI: 10.29399/npa.21650 İndeks Tarihi: 05-11-2020

Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments

Öz:

Introduction: Migraine has been known for many years, but itsmechanism remains unclear. Different cerebral hemodynamic changeshave been observed at different stages of a migraine attack. Publishedresults on cerebral hemodynamics are contradictory. For this reason, weaimed to investigate cerebral hemodynamic changes during attacks aswell as the effects of frovatriptan and rizatriptan.Methods: Forty migraine patients with aura using rizatriptan (n=20)and frovatriptan (n=20) and 20 healthy individuals were included in ourstudy. Cerebral blood flow velocities and breath-holding indices wererecorded bilaterally from middle and posterior cerebral arteries. Allprocedures were repeated one hour after treatments and one week afterattacks.Results: We observed similar values of cerebral blood flow velocities andbreath holding indices in all patients with migraine during the attack-freeperiod compared to the control group. All cerebral vascular structures inmigraine patients had significantly lower cerebral blood flow velocitiesand higher values in breath-holding indices during attacks. After takingrizatriptan and frovatriptan for an attack, the changes in hemodynamicsdisappeared.Conclusion: During attacks of migraineurs with aura, vasodilatationdevelops. In addition, higher vasomotor reactivity during attackssupports hypersensitivity in migraine pathophysiology. Triptans, actingas vasoconstrictor agents, were able to stop over-vasodilatation duringattacks. In other words, it is possible that triptans show their effects byeliminating vascular hypersensitivity during acute attacks.

Anahtar Kelime:

Migren Atağında ve Triptan Tedavisi Sonrasında Serebral Hemodinamik Değişiklikler

Öz:

Giriş: Migren uzun yıllardan beri bilinen ama sebebi ve mekanizması halen tam olarak açıklanamayan kompleks bir hastalıktır. Migren atağının farklı dönemlerinde farklı hemodinamik değişiklikler gözlenmektedir. Serebral hemodinami üzerine yapılan çalışma sonuçları karışıktır. Bu sebepten, frovatriptan ve rizatriptanın migren atağında serebral hemodinami üzerine etkilerini araştırmak istedik. Yöntem: Çalışmaya frovatriptan (n=20) ve rizatriptan (n=20) kullanan 40 auralı migren hastası ve sağlıklı 20 birey alındı. Bilateral Orta serebral arter ve arka serebral arter kayıtları ve nefes tutma indeksleri hesaplandı. Tedaviden bir saat ve ataktan bir hafta sonra işlemler tekrarlandı. Bulgular: Çalışma sonucunda migrenli hastaların tamamında ataksız dönemde kontrol grubu ile benzer serebral kan akım hızları ve nefes tutma indeksleri saptadık. Atak esnasında migrenli hastalarda incelenen bütün serebral vasküler yapılarda serebral kan akım hızları anlamlı derecede düşük, nefes tutma indeksleri ise anlamlı derecede artmış olarak saptandı. Kullanılan frovatriptan ve rizatriptan sonrasında atak esnasında saptanan bu değişikliğin ortadan kaybolduğu saptandı. Sonuç: Auralı migrenlilerde atak esnasında vazodilatasyon gelişmektedir. Ayrıca atak esnasında vazomotor reaktivitenin sağlıklı bireylere göre daha yüksek saptanması da migrenlilerde bir hipersensitiviteyi desteklemektedir. Vazokonstriktör etki gösteren triptanların atak esnasında ortaya çıkan aşırı vazodilatasyonu yok ettikleri gösterildi. Bir başka deyişle, triptanların etkilerini akut atak esnasında vasküler etkilenme ile gelişen hipersensitiviteyi ortadan kaldırarak gösterdiğini söylemek mümkündür.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	öztürk b, karadaş ö (2020). Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments. , 192 - 196. 10.29399/npa.21650
Chicago	öztürk bilgin,karadaş ömer Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments. (2020): 192 - 196. 10.29399/npa.21650
MLA	öztürk bilgin,karadaş ömer Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments. , 2020, ss.192 - 196. 10.29399/npa.21650
AMA	öztürk b,karadaş ö Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments. . 2020; 192 - 196. 10.29399/npa.21650
Vancouver	öztürk b,karadaş ö Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments. . 2020; 192 - 196. 10.29399/npa.21650
IEEE	öztürk b,karadaş ö "Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments." , ss.192 - 196, 2020. 10.29399/npa.21650
ISNAD	öztürk, bilgin - karadaş, ömer. "Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments". (2020), 192-196. https://doi.org/10.29399/npa.21650

APA	öztürk b, karadaş ö (2020). Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments. Nöropsikiyatri Arşivi, 57(3), 192 - 196. 10.29399/npa.21650
Chicago	öztürk bilgin,karadaş ömer Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments. Nöropsikiyatri Arşivi 57, no.3 (2020): 192 - 196. 10.29399/npa.21650
MLA	öztürk bilgin,karadaş ömer Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments. Nöropsikiyatri Arşivi, vol.57, no.3, 2020, ss.192 - 196. 10.29399/npa.21650
AMA	öztürk b,karadaş ö Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments. Nöropsikiyatri Arşivi. 2020; 57(3): 192 - 196. 10.29399/npa.21650
Vancouver	öztürk b,karadaş ö Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments. Nöropsikiyatri Arşivi. 2020; 57(3): 192 - 196. 10.29399/npa.21650
IEEE	öztürk b,karadaş ö "Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments." Nöropsikiyatri Arşivi, 57, ss.192 - 196, 2020. 10.29399/npa.21650
ISNAD	öztürk, bilgin - karadaş, ömer. "Cerebral Hemodynamic Changes During Migraine Attacks and After Triptan Treatments". Nöropsikiyatri Arşivi 57/3 (2020), 192-196. https://doi.org/10.29399/npa.21650