Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi

Tuğba DEMİR, (Sivas Cumhuriyet Üniversitesi, Veteriner Fakültesi, Gıda Hijyeni ve Teknolojisi Bölümü, Sivas, Türkiye)
Özlem AKPINAR, (Gaziosmanpaşa Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Gıda Mühendisliği Bölümü, Tokat, Türkiye)
Haki KARA, (Sivas Cumhuriyet Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Bölümü, Sivas, Türkiye)
Hüseyin GÜNGÖR (Sivas Cumhuriyet Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Bölümü, Sivas, Türkiye)
Akademik Gıda
17 2
Yıl: 2019 Cilt: 17 Sayı: 1 Sayfa Aralığı: 61 - 71 Metin Dili: Türkçe DOI: 10.24323/akademik-gida.544647 İndeks Tarihi: 06-11-2020

Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi

Öz:
Bu çalışmada nar (Punica granatum L.) kabuğunun sağlık açısından önemli antioksidan, antimikrobiyal, antidiyabetik,antienflamatuar ve sitotoksik özellikleri araştırılmıştır. Nar kabukları (%33 etanol konsantrasyonu, 78°C, 113 dakika)ekstrakte edilerek fenolik bileşiklerinin kompozisyonu belirlenmiş, yüksek oranda punigalajin, kafeik asit ve epikateşiniçerdiği ve yüksek antioksidan kapasiteye sahip olduğu tespit edilmiştir. Elde edilen ekstrakt aynı zamanda, seçilenmikroorganizmalara (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Aspergillus flavus veAspergillus niger) karşı antimikrobiyal etki göstermiş ve en fazla mikrobiyal direnci S. aureus’a (21 mm; 1.87 mgekstrakt/mL) karşı olduğu bulunmuştur. Ekstrakt α-amilaz ve α-glukozidaz enzimlerini inhibe etmiş ve antidiyabetiközellik göstermiştir. Aynı zamanda ekstraktın enflamasyondan sorumlu ksantin oksidaz ve lipoksigenaz enzimlerini deinhibe edebildiği ve meme ve kemik kanseri hücreleri üzerinde sitotoksik aktiviteye sahip olduğu da gözlenmiştir. Narkabuğu ekstraktının belirlenen biyolojik aktiviteleri ile gıda ve gıda dışı uygulamalarda kullanılabileceği sonucunavarılmıştır.
Anahtar Kelime:

In Vitro Antidiabetic, Antiinflammatory, Cytotoxic, Antioxidant and Antimicrobial Activities of Pomegranate (Punica granatum L.) Peel

Öz:
In this study, antioxidant, antimicrobial, antidiabetic, antiinflammatory and cytotoxic properties of the pomegranate (Punica granatum L.) peel were investigated. The composition of the phenolic compounds of the pomegranate peel extract (33%, 78°C, 113 min) was determined and it was found to contain high amounts of punigalagin, caffeic acid and epicatechin. At the same time, the extract was found to have high antioxidant capacity. It showed antimicrobial activity against selected microorganisms (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Aspergillus flavus and Aspergillus niger) and its highest microbial resistance was found to be against S. aureus (21 mm; 1.87 mg extract /mL). It inhibited α-amylase and α-glucosidase enzymes and showed the antidiabetic property. At the same time, the extract was able to inhibit xanthine oxidase and lipoxygenase enzymes that were responsible for the inflammation and its cytotoxic activity on breast and bone cancer cells were also observed. It was concluded that pomegranate peel extracts could be used in food and non-food applications due to its biological activities.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA DEMIR T, AKPINAR O, KARA H, GÜNGÖR H (2019). Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi. , 61 - 71. 10.24323/akademik-gida.544647
Chicago DEMIR TUGBA,AKPINAR OZLEM,KARA Haki,GÜNGÖR HÜSEYİN Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi. (2019): 61 - 71. 10.24323/akademik-gida.544647
MLA DEMIR TUGBA,AKPINAR OZLEM,KARA Haki,GÜNGÖR HÜSEYİN Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi. , 2019, ss.61 - 71. 10.24323/akademik-gida.544647
AMA DEMIR T,AKPINAR O,KARA H,GÜNGÖR H Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi. . 2019; 61 - 71. 10.24323/akademik-gida.544647
Vancouver DEMIR T,AKPINAR O,KARA H,GÜNGÖR H Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi. . 2019; 61 - 71. 10.24323/akademik-gida.544647
IEEE DEMIR T,AKPINAR O,KARA H,GÜNGÖR H "Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi." , ss.61 - 71, 2019. 10.24323/akademik-gida.544647
ISNAD DEMIR, TUGBA vd. "Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi". (2019), 61-71. https://doi.org/10.24323/akademik-gida.544647
APA DEMIR T, AKPINAR O, KARA H, GÜNGÖR H (2019). Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi. Akademik Gıda, 17(1), 61 - 71. 10.24323/akademik-gida.544647
Chicago DEMIR TUGBA,AKPINAR OZLEM,KARA Haki,GÜNGÖR HÜSEYİN Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi. Akademik Gıda 17, no.1 (2019): 61 - 71. 10.24323/akademik-gida.544647
MLA DEMIR TUGBA,AKPINAR OZLEM,KARA Haki,GÜNGÖR HÜSEYİN Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi. Akademik Gıda, vol.17, no.1, 2019, ss.61 - 71. 10.24323/akademik-gida.544647
AMA DEMIR T,AKPINAR O,KARA H,GÜNGÖR H Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi. Akademik Gıda. 2019; 17(1): 61 - 71. 10.24323/akademik-gida.544647
Vancouver DEMIR T,AKPINAR O,KARA H,GÜNGÖR H Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi. Akademik Gıda. 2019; 17(1): 61 - 71. 10.24323/akademik-gida.544647
IEEE DEMIR T,AKPINAR O,KARA H,GÜNGÖR H "Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi." Akademik Gıda, 17, ss.61 - 71, 2019. 10.24323/akademik-gida.544647
ISNAD DEMIR, TUGBA vd. "Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi". Akademik Gıda 17/1 (2019), 61-71. https://doi.org/10.24323/akademik-gida.544647
Sayfa Oluşturulma Tarihi
23-04-2024 14:49

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