IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors

Hashem, Heba

doi:10.14744/ejmo.2020.36102

IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors

Heba E. HASHEM (Ain Shams University, Faculty of Women, Department of Chemistry, Cairo, Egyp)

Eurasian Journal of Medicine and Oncology

1 0

Yıl: 2020 Cilt: 4 Sayı: 3 Sayfa Aralığı: 196 - 200 Metin Dili: İngilizce DOI: 10.14744/ejmo.2020.36102 İndeks Tarihi: 07-11-2020

IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors

Öz:

Objectives: The huge attack of coronavirus disease 2019 (COVID-19) over all the world forces the researcher aroundthe world to study the crystal structure of the main protease Mpro (3-chymotrypsin-like cysteine enzyme) which is theessential enzyme for coronavirus processing the polyproteins and its life cycles. And by the way, the inhibition of thisenzyme active site becomes the target of all scientists of drug discovery in order to overcome this disease.Methods: In this study, we have used the molecular modeling approach to evaluate the activity of different active compounds from honeybee and propolis to inhibit the presented sars-cov-2 main protease via Schrödinger Maestro v10.1.Results: The presented study resulted in six main compounds possess high binding energy with the receptor activesite of COVID-19 main protease.Conclusion: We hope this study being the way for honeybee constitution as an effective ligand for sars-cov-2 mainprotease inhibition and be in the medicinal study of anti-COVID-19 therapeutic drugs.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Hashem H (2020). IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors. , 196 - 200. 10.14744/ejmo.2020.36102
Chicago	Hashem Heba IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors. (2020): 196 - 200. 10.14744/ejmo.2020.36102
MLA	Hashem Heba IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors. , 2020, ss.196 - 200. 10.14744/ejmo.2020.36102
AMA	Hashem H IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors. . 2020; 196 - 200. 10.14744/ejmo.2020.36102
Vancouver	Hashem H IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors. . 2020; 196 - 200. 10.14744/ejmo.2020.36102
IEEE	Hashem H "IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors." , ss.196 - 200, 2020. 10.14744/ejmo.2020.36102
ISNAD	Hashem, Heba. "IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors". (2020), 196-200. https://doi.org/10.14744/ejmo.2020.36102

APA	Hashem H (2020). IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors. Eurasian Journal of Medicine and Oncology, 4(3), 196 - 200. 10.14744/ejmo.2020.36102
Chicago	Hashem Heba IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors. Eurasian Journal of Medicine and Oncology 4, no.3 (2020): 196 - 200. 10.14744/ejmo.2020.36102
MLA	Hashem Heba IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors. Eurasian Journal of Medicine and Oncology, vol.4, no.3, 2020, ss.196 - 200. 10.14744/ejmo.2020.36102
AMA	Hashem H IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors. Eurasian Journal of Medicine and Oncology. 2020; 4(3): 196 - 200. 10.14744/ejmo.2020.36102
Vancouver	Hashem H IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors. Eurasian Journal of Medicine and Oncology. 2020; 4(3): 196 - 200. 10.14744/ejmo.2020.36102
IEEE	Hashem H "IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors." Eurasian Journal of Medicine and Oncology, 4, ss.196 - 200, 2020. 10.14744/ejmo.2020.36102
ISNAD	Hashem, Heba. "IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors". Eurasian Journal of Medicine and Oncology 4/3 (2020), 196-200. https://doi.org/10.14744/ejmo.2020.36102