Yıl: 2020 Cilt: 26 Sayı: 1 Sayfa Aralığı: 63 - 66 Metin Dili: İngilizce DOI: 10.14744/tjtes.2019.14799 İndeks Tarihi: 10-11-2020

High C-reactive protein level as a predictor for appendiceal perforation

Öz:
BACKGROUND: Between 18% and 34% of acute appendicitis (AA) patients may have complicated appendicitis. Perforation is themost important complication of AA. Perforation increases morbidity and mortality. In this study, we aimed to investigate the role ofbasic inflammatory markers in the diagnosis of perforated AA.METHODS: A retrospective chart review was conducted of patients who underwent appendectomy with a diagnosis of AA betweenJanuary 2014 and October 2019 at Akdeniz University Faculty of Medicine; and between December 2017 and October 2019 at IstinyeUniversity Faculty of Medicine Hospital. Markers recorded were as follows: white blood cell count, neutrophils, lymphocytes, platelets,c-reactive protein, mean platelet volume, red cell distribution width and eosinophils. Hematological indices were combined to generatethe following three ratios: white cell neutrophil ratio, platelet lymphocyte ratio and neutrophil-lymphocyte ratio.RESULTS: A total of 536 patients with a diagnosis of AA underwent an operation. There were 344 (64.1%) male patients and 192(35.9%) female patients. The mean age of the patients was 36.7±16.2 (15-88) years. There were 94 (17.5%) patients with perforatedAA and 442 (82.5%) patients with non-perforated AA. C-reactive protein (AUC: 0.81, p<0.001) was the most accurate markers indistinguishing the perforated and non-perforated group.CONCLUSION: Elevated CRP level is a nonspecific inflammatory marker in most of the inflammatory diseases. A high CRP levelcan, therefore, be used as a supplement in the diagnosis of perforated AA.
Anahtar Kelime:

Yüksek C-reaktif protein seviyesi apendiks perforasyonu için belirteç olabilir

Öz:
AMAÇ: Akut apandisit (AA) hastalarının %18 ile %34’ü komplike apandisit tanısı almıştır. AA’nın en önemli komplikasyonu perforasyondur. Perforasyon morbidite ve mortaliteyi arttırır. Bu çalışmada temel enflamatuvar belirteçlerin perfore AA tanısındaki rolünü araştırmayı amaçladık. GEREÇ VE YÖNTEM: Akdeniz Üniversitesi Tıp Fakültesi’nde; Ocak 2014–Ekim 2019 ve Aralık 2017–Ekim 2019 tarihleri arasında İstinye Üniversitesi Tıp Fakültesi Hastanesi’nde AA tanısı ile apendektomi yapılan hastaların retrospektif dosya incelemesi yapıldı. Kaydedilen belirteçler aşağıdaki gibiydi: lökosit sayısı, nötrofil, lenfosit, trombosit sayımı, C-reaktif protein, ortalama trombosit hacmi, kırmızı hücre dağılım genişliği ve eozinofiller. Aşağıdaki üç oranın üretilmesi için hematolojik endeksler çalıştırıldı; beyaz küre nötrofil oranı, trombosit lenfosit oranı ve nötrofil lenfosit oranı. BULGULAR: Akut apandisit tanısı olan toplam 536 hasta ameliyat edildi. Bu hastaların 344’ü (%64.1) erkek ve 192’si (%35.9) kadın idi. Hastaların yaş ortalaması 36.7±16.2 (15–88) idi. Perfore AA olan 94 (%17.5) ve perfore olmayan AA olan 442 (%82.5) hasta vardı. C-reaktif protein (AUC: 0.81, p<0.001), perfore ve perfore olmayan grubun ayırt edilmesinde en doğru belirteç olarak tespit edildi. TARTIŞMA: Yüksek CRP seviyesi, enflamatuvar hastalıkların çoğunda spesifik olmayan bir enflamatuvar belirteçtir, bu nedenle yüksek CRP seviyesi, perfore AA’nın tanısında bir tamamlayıcı olarak kullanılabilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ÖZOZAN Ö, VURAL V (2020). High C-reactive protein level as a predictor for appendiceal perforation. , 63 - 66. 10.14744/tjtes.2019.14799
Chicago ÖZOZAN Ömer Vefik,VURAL Veli High C-reactive protein level as a predictor for appendiceal perforation. (2020): 63 - 66. 10.14744/tjtes.2019.14799
MLA ÖZOZAN Ömer Vefik,VURAL Veli High C-reactive protein level as a predictor for appendiceal perforation. , 2020, ss.63 - 66. 10.14744/tjtes.2019.14799
AMA ÖZOZAN Ö,VURAL V High C-reactive protein level as a predictor for appendiceal perforation. . 2020; 63 - 66. 10.14744/tjtes.2019.14799
Vancouver ÖZOZAN Ö,VURAL V High C-reactive protein level as a predictor for appendiceal perforation. . 2020; 63 - 66. 10.14744/tjtes.2019.14799
IEEE ÖZOZAN Ö,VURAL V "High C-reactive protein level as a predictor for appendiceal perforation." , ss.63 - 66, 2020. 10.14744/tjtes.2019.14799
ISNAD ÖZOZAN, Ömer Vefik - VURAL, Veli. "High C-reactive protein level as a predictor for appendiceal perforation". (2020), 63-66. https://doi.org/10.14744/tjtes.2019.14799
APA ÖZOZAN Ö, VURAL V (2020). High C-reactive protein level as a predictor for appendiceal perforation. Ulusal Travma ve Acil Cerrahi Dergisi, 26(1), 63 - 66. 10.14744/tjtes.2019.14799
Chicago ÖZOZAN Ömer Vefik,VURAL Veli High C-reactive protein level as a predictor for appendiceal perforation. Ulusal Travma ve Acil Cerrahi Dergisi 26, no.1 (2020): 63 - 66. 10.14744/tjtes.2019.14799
MLA ÖZOZAN Ömer Vefik,VURAL Veli High C-reactive protein level as a predictor for appendiceal perforation. Ulusal Travma ve Acil Cerrahi Dergisi, vol.26, no.1, 2020, ss.63 - 66. 10.14744/tjtes.2019.14799
AMA ÖZOZAN Ö,VURAL V High C-reactive protein level as a predictor for appendiceal perforation. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(1): 63 - 66. 10.14744/tjtes.2019.14799
Vancouver ÖZOZAN Ö,VURAL V High C-reactive protein level as a predictor for appendiceal perforation. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(1): 63 - 66. 10.14744/tjtes.2019.14799
IEEE ÖZOZAN Ö,VURAL V "High C-reactive protein level as a predictor for appendiceal perforation." Ulusal Travma ve Acil Cerrahi Dergisi, 26, ss.63 - 66, 2020. 10.14744/tjtes.2019.14799
ISNAD ÖZOZAN, Ömer Vefik - VURAL, Veli. "High C-reactive protein level as a predictor for appendiceal perforation". Ulusal Travma ve Acil Cerrahi Dergisi 26/1 (2020), 63-66. https://doi.org/10.14744/tjtes.2019.14799