Antimicrobial essential oil of Origanum boissieri Ietswaart

Gökalp İŞCAN, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Eskişehir, Türkiye)
Betül DEMİRCİ, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Eskişehir, Türkiye)
Yavuz Bülent KÖSE (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Botanik Anabilim Dalı, Eskişehir, Türkiye)
Journal of research in pharmacy (online)
1 0
Yıl: 2020 Cilt: 24 Sayı: 2 Sayfa Aralığı: 233 - 239 Metin Dili: İngilizce DOI: 10.35333/jrp.2020.140 İndeks Tarihi: 10-11-2020

Antimicrobial essential oil of Origanum boissieri Ietswaart

Öz:
Apart from being a popular spice, Origanum species is very important taxa as an herbal medicine for theirseveral pharmacological activities. Essential oils of Origanum species bearing phenolic monoterpenoids such ascarvacrol and thymol demonstrated strong antimicrobial properties. In the present study hydrodistilled essential oil ofendemic species Origanum boissieri Ietswaart were analysed by GC and GC/MS techniques simultaneously. Thirtycompounds representing 95.1 % of the total oil were identified. Carvacrol (39%) and p-cymene (32%) were detected asthe main components of the oil. Total methanol extract and essential oil of the flowering aerial parts of the plant withthe carvacrol and p-cymene were screened for its antibacterial and anticandidal properties by using microdilution brothassay. Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Staphlylococcus epidermidis and Listeria monocytogenes werestrongly inhibited by the oil between the concentrations of 15,6 - 62.5 µg/mL. O. boissieri extract and the oil showedmoderate effects against all tested Candida strains having MIC values of 125-1000 µg/mL.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • [1] Ietswaart JH. A Taxonomic Revision of the Genus Origanum (Labiatae). Leiden Botanical Series 4. Leiden University Press, The Hague, The Netherlands 1980
  • [2] Kokkini S. Taxonomy, diversity and distribution of Origanum species, In: Padulosi S. (Ed.). Oregano. 14th Proceedings of the IPGRI International Workshop on Oregano, 8-12 May 1996, CIHEAM, Valenzano (Bari), 1996. pp.2-12.
  • [3] Sadıkoğlu N, Özhatay N. Morphological characteristics of exported taxa as Oregano from Turkey I: Origanum. J Faculty Pharm Istanbul Univ. 2015; 45(2): 87-126.
  • [4] Başer KHC. The Turkish Origanum species. In: Kintzios E. (Ed.) Oregano: The genera Origanum and Lippia. Taylor & Francis; London, 2002, pp.109-126.
  • [5] Başer KHC, Özek T, Tümen G, Sezik, E. Composition of the essential oils of Turkish Origanum species with commercial importance. J Essent Oil Res. 1993; 5: 619-623. [CrossRef]
  • [6] Baricevic D, Bartol T. The biological/pharmacological activity of the Origanum genus. In: Kintzios E. (Ed.) Oregano: the genera Origanum and Lippia. Taylor and Francis, London, 2002, pp.177-214.
  • [7] Şahin F, Güllüce M., Daferera D, Sökmen A, Sökmen M, Polissiou M, Agar G, Özer H. Biological activities of the essential oils and methanol extract of Origanum vulgare ssp. vulgare in the Eastern Anatolia region of Turkey. Food Control, 2004; 15(7): 549-557. [CrossRef]
  • [8] Chishti S, Kaloo ZA, Sultan P. Medicinal importance of genus Origanum: A review. J Pharmacognosy Phytother. 2013; 5(10): 170-177.
  • [9] Ličina BZ, Stefanović OD, Vasić SM, Radojević ID, Dekić MS, Čomić LR. Biological activities of the extracts from wild growing Origanum vulgare L. Food Control. 2013; 33(2): 498-504. [CrossRef]
  • [10] Han X, Parker TL. Anti-inflammatory, tissue remodeling, immunomodulatory, and anticancer activities of oregano (Origanum vulgare) essential oil in a human skin disease model. Biochimie Open. 2017; 4: 73-77. [CrossRef]
  • [11] Elshafie HS, Armentano MF, Carmosino M, Bufo SA, De Feo V, Camele I. Cytotoxic activity of Origanum vulgare L. on hepatocellular carcinoma cell line HepG2 and evaluation of its biological activity. Molecules. 2017; 22(9): 1435. [CrossRef]
  • [12] Adam K, Sivropoulou A, Kokkini S, Lanaras T, Arsenakis M. Antifungal activities of Origanum vulgare subsp. hirtum, Mentha spicata, Lavandula angustifolia, and Salvia fruticosa essential oils against human pathogenic fungi. J Agric Food Chem. 1998; 46(5): 1739-1745. [CrossRef]
  • [13] Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oils–a review. Food Chem Toxicol. 2008; 46(2): 446-475. [CrossRef]
  • [14] Soković M, Glamočlija J, Marin PD, Brkić D, van Griensven LJ. Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model. Molecules. 2010; 15(11): 7532-7546. [CrossRef]
  • [15] Leyva-López N, Gutiérrez-Grijalva EP, Vazquez-Olivo G, Heredia JB. Essential oils of oregano: Biological activity beyond their antimicrobial properties. Molecules. 2017; 22(6): 989. [CrossRef]
  • [16] Lambert RJ, Skandamis PN, Coote PJ, Nychas GJ. A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol, J Appl Microbiol. 2001; 91: 453-462. [CrossRef]
  • [17] Nostro A, Blanco AR, Cannatelli MA, Enea V, Flamini G, Morelli I, Sudano RA, Alonzo V. Susceptibility of methicillin-resistant Staphylococci to oregano essential oil, carvacrol and thymol. FEMS Micro Lett. 2004; 230: 191-195. [CrossRef]
  • [18] Nostro A, Roccaro SA, Bisignano G, Marino A, Cannatelli MA, Pizzimenti FC, Cioni PL, Procopio F, Blanco AR. Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms. J Med Microbiol. 2007; (56)4: 519-523. [CrossRef]
  • [19] Kotan R, Kordali S, Çakır A. Screening of antibacterial activities of twenty-one oxygenated monoterpenes. Z Naturforsch C. 2007; 62(7-8): 507-513. [CrossRef]
  • [20] Xu J, Zhou F, Ji BP, Pei RS, Xu N. The antibacterial mechanism of carvacrol and thymol against Escherichia coli. Letters App Microbiol. 2008; 47, 174–179. [CrossRef]
  • [21] Carson CF, Hammer KA. Chemistry and Bioactivity of Essential Oils, In: Thormar H. (Ed.) Lipids and Essential Oils as Antimicrobial Agents. John Wiley & Sons, Ltd., New York, 2011. pp.203-238.
  • [22] De Martino L, De Feo V, Fratianni F, Nazzaro F. Chemistry, antioxidant, antibacterial and antifungal activities of volatile oils and their components. Nat Prod Commun. 2009; 4 :1741–1746. [CrossRef]
  • [23] Du E, Gan L, Li Z, Wang W, Liu D, Guo Y. In vitro antibacterial activity of thymol and carvacrol and their effects on broiler chickens challenged with Clostridium perfringens. J Anim Sci Biotechnol. 2015; 6: 58. [CrossRef]
  • [24] Khan ST, Khan M, Ahmad J, Wahab R, Abd-Elkader OH., Musarrat J, Alkhathlan HZ, Al-Kedhairy AA. Thymol and carvacrol induce autolysis, stress, growth inhibition and reduce the biofilm formation by Streptococcus mutans. AMB Express. 2017; 7(1): 49. [CrossRef]
  • [25] Edris AE. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: A review. Phytother Res. 2007; 21: 308-323. [CrossRef]
  • [26] Ietswaart JH. Origanum L. In: Davis PH. (Ed.). Vol. 7 Flora of Turkey and the East Aegean Islands: Edinburgh Univ. Press, Edinburgh, 1982, pp.299.
  • [27] Başer KHC, Duman H. Composition of the Essential Oils of Origanum boissieri letswaart and O. bargyli Mouterde. J Essent Oil Res. 1998; 10: 71-72. [CrossRef]
  • [28] McLafferty FW, Stauffer DB. The Wiley/NBS Registry of Mass Spectral Data, J Wiley and Sons, New York, pp.1989.
  • [29] Koenig WA, Joulain D, Hochmuth DH. Terpenoids and Related Constituents of Essential Oils. MassFinder 3, Hamburg, Germany, 2004.
  • [30] Joulain D, Koenig WA. The Atlas of Spectra Data of Sesquiterpene Hydrocarbons, EB-Verlag, Hamburg, 1998, pp.10- 658.
  • [31] ESO 2000. (The Complete Database of Essential Oils) program, https://www.leffingwell.com/virtual_xp_mode.htm (accessed on 12 June 2017).
  • [32] National Committee for Clinical Laboratory Standards. Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved Standard-M27A2. CLSI, Wayne PA, USA. 2002.
  • [33] National Committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. Approved Standard-M7A7. Wayne PA, USA. 2006.
  • [34] Rahalison L, Hamburger M, Hostettmann K, Monod M, Frenk EA, Bioautographic agar overlay method for the detection of antifungal compounds from higher plants. Phytochem Anal. 1991; 2: 199-203. [CrossRef]
  • [35] Hostettmann K. Strategy for the biological evaluation of plant extracts. Pure App Chem. 1999; 70: 1109-1113.
  • [36] İşcan G. Antibacterial and anticandidal activities of common essential oil constituents. Rec Nat Prod. 2017; 11(4): 374- 388. [CrossRef]
  • [37] Nazzaro F, Fratianni F, De Martino L, Coppola R, De Feo V. Effect of essential oils on pathogenic bacteria. Pharmaceuticals (Basel). 2013; 6: 1451-1474. [CrossRef]
  • [38] Souza NAB, Lima EDO, Guedes DN, Pereira, FDO, Souza ELD, Sousa FBD. Efficacy of Origanum essential oils for inhibition of potentially pathogenic fungi. Braz J Pharm Sci. 2010; 46(3): 499-508. [CrossRef]
APA ISCAN G, Demirci B, Köse Y (2020). Antimicrobial essential oil of Origanum boissieri Ietswaart. , 233 - 239. 10.35333/jrp.2020.140
Chicago ISCAN GOKALP,Demirci Betül,Köse Yavuz Bülent Antimicrobial essential oil of Origanum boissieri Ietswaart. (2020): 233 - 239. 10.35333/jrp.2020.140
MLA ISCAN GOKALP,Demirci Betül,Köse Yavuz Bülent Antimicrobial essential oil of Origanum boissieri Ietswaart. , 2020, ss.233 - 239. 10.35333/jrp.2020.140
AMA ISCAN G,Demirci B,Köse Y Antimicrobial essential oil of Origanum boissieri Ietswaart. . 2020; 233 - 239. 10.35333/jrp.2020.140
Vancouver ISCAN G,Demirci B,Köse Y Antimicrobial essential oil of Origanum boissieri Ietswaart. . 2020; 233 - 239. 10.35333/jrp.2020.140
IEEE ISCAN G,Demirci B,Köse Y "Antimicrobial essential oil of Origanum boissieri Ietswaart." , ss.233 - 239, 2020. 10.35333/jrp.2020.140
ISNAD ISCAN, GOKALP vd. "Antimicrobial essential oil of Origanum boissieri Ietswaart". (2020), 233-239. https://doi.org/10.35333/jrp.2020.140
APA ISCAN G, Demirci B, Köse Y (2020). Antimicrobial essential oil of Origanum boissieri Ietswaart. Journal of research in pharmacy (online), 24(2), 233 - 239. 10.35333/jrp.2020.140
Chicago ISCAN GOKALP,Demirci Betül,Köse Yavuz Bülent Antimicrobial essential oil of Origanum boissieri Ietswaart. Journal of research in pharmacy (online) 24, no.2 (2020): 233 - 239. 10.35333/jrp.2020.140
MLA ISCAN GOKALP,Demirci Betül,Köse Yavuz Bülent Antimicrobial essential oil of Origanum boissieri Ietswaart. Journal of research in pharmacy (online), vol.24, no.2, 2020, ss.233 - 239. 10.35333/jrp.2020.140
AMA ISCAN G,Demirci B,Köse Y Antimicrobial essential oil of Origanum boissieri Ietswaart. Journal of research in pharmacy (online). 2020; 24(2): 233 - 239. 10.35333/jrp.2020.140
Vancouver ISCAN G,Demirci B,Köse Y Antimicrobial essential oil of Origanum boissieri Ietswaart. Journal of research in pharmacy (online). 2020; 24(2): 233 - 239. 10.35333/jrp.2020.140
IEEE ISCAN G,Demirci B,Köse Y "Antimicrobial essential oil of Origanum boissieri Ietswaart." Journal of research in pharmacy (online), 24, ss.233 - 239, 2020. 10.35333/jrp.2020.140
ISNAD ISCAN, GOKALP vd. "Antimicrobial essential oil of Origanum boissieri Ietswaart". Journal of research in pharmacy (online) 24/2 (2020), 233-239. https://doi.org/10.35333/jrp.2020.140
Sayfa Oluşturulma Tarihi
23-04-2024 14:57

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