Yıl: 2020 Cilt: 19 Sayı: 2 Sayfa Aralığı: 71 - 77 Metin Dili: İngilizce DOI: 10.4274/eajem.galenos.2020.92063 İndeks Tarihi: 14-11-2020

The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism

Öz:
Aim: Pulmonary embolism (PE) is a life-threatening condition that requires early diagnosis and treatment. There is still a need for precise and non-invasive biomarkers that can be used to diagnose PE. This study aimed to determine the diagnostic value of Cardiotrophin-1 (CT-1) in patients with acute PE and ascertain the relationship between serum CT-1 level and disease prognosis and severity. Materials and Methods: In this prospective study, the serum CT-1 levels of 165 patients with suspected acute PE were measured. The patients were divided into two groups, PE (+) and PE (−), based on their computed tomography angiography results. Their serum CT-1 levels were compared.Results: The CT-1 levels of the PE (+) group (median=4.18 pg/mL, range=3.57-9.55 pg/mL) was non-significantly (p=0.08) different from those of the PE (−) group (median=4.38 pg/mL, range=3.57-51.64 pg/mL). Based on the severity of the condition, there were significant differences (p=0.001) in the CT-1 levels of the patients in the intermediate-low risk group (median=4.19 pg/mL, range=3.62-5.32 pg/mL), intermediate-high risk group (median=4.06 pg/mL, range=3.57-9.31 pg/mL) and high risk group (median=5.01 pg/mL, range=3.89-9.55 pg/mL). Based on the clinical course, the CT-1 levels of the patients in the good clinical course group (median=4.15 pg/mL, range=3.57-9.31 pg/ml) were significantly different (p=0.004) from those in the poor clinical course group (median=4.53 pg/mL, range=3.66-9.55 pg/mL).Conclusion: CT-1 level was not observed to be a precise biomarker for the diagnosis of acute PE. However, our study demonstrated that the serum CT-1 levels can be used as a biomarker for ascertaining the severity and prognosis of patients with PE.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
0
0
0
  • 1. Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2020;41:543-603.
  • 2. Ribeiro A, Juhlin-Dannfelt A, Brodin LA, Holmgren A, Jorfeldt L. Pulmonary embolism: relation between the degree of right ventricle overload and the extent of perfusion defects. Am Heart J. 1998;135:868-74.
  • 3. Stein PD, Hull RD, Patel KC, Olson RE, GhaliWA, Brant R, et al. D-dimer for theexclusion of acute venous thrombosis and pulmonary embolism: a systematic review. Ann Intern Med. 2004;140;589:602-51.
  • 4. Meyer G, Vicaut E, Danays T, Agnelli G, Becattini C, Beyer-Westendorf J, et al. Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med. 2014;370:1402-11.
  • 5. Aujesky D, Obrosky DS, Stone RA, Auble TE, Perrier A, Cornuz J, et al. Derivation and validation of a prognostic model for pulmonary embolism. Am J Respir Crit Care Med. 2005;172:1041-6.
  • 6. Jiménez D, Kopecna D, Tapson V, Briese B, Schreiber D, Lobo JL, et al. Derivation and validation of multimarker prognostication for normotensive patients with acute symptomatic pulmonary embolism. Am J Respir Crit Care Med. 2014;189:718-26.
  • 7. Aujesky D, Roy PM, Verschuren F, Righini M, Osterwalder J, Egloff M, et al. Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trial. Lancet. 2011;378:41-8.
  • 8. Pennica D, King KL, Shaw KJ, Luis E, Rullamas J, Luoh SM, et al. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci USA. 1995;92:1142-6.
  • 9. Pennica D, Swanson TA, Shaw KJ, Kuang WJ, Gray CL, Beatty BG, et al. Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomallocalization. Cytokine. 1996;8:183-9.
  • 10. Caliskan S, Besli F, Yildirim A, Gungoren F, Alisir MF, Polat U, et al. The relationship between cardiotrophin-1 and troponin-i in coronary arterial bypass grafting on the beating heart: a prospective study. Heart Surg Forum. 2015;18:146-50.
  • 11. Kumar BP, Rajasekhar D, Vanajakshamma V. Study of clinical, radiological and echocardiographic features and correlation of Qanadli CT index with RV dysfunction and outcomes in pulmonary embolism. Indian Heart Journal. 2014;66:629-34.
  • 12. González A, López B, Ravassa S, Beaumont J, Zudaire A, Gallego I, et al. Cardiotrophin-1 in hypertensive heart disease. Endocrine. 2012;42:9-17.
  • 13. Konii H, Sato K, Kikuchi S, Okiyama H, Watanabe R, Hasegawa A, et al. Stimulatory effects of cardiotrophin-1 on atherosclerosis. Hypertension. 2013;62:942-50.
  • 14. Ichiki T, Jougasaki M, Setoguchi M, Imamura J, Nakashima H, Matsuoka T, et al. Cardiotrophin-1 stimulates intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human aortic endothelial cells. Am J Physiol Heart Circ Physiol. 2008;294:H750-63.
  • 15. Calabrò P, Limongelli G, Riegler L, Maddaloni V, Palmieri R, Golia E, et al. Novel insights into the role of cardiotrophin-1 in cardiovascular diseases. J Mol Cell Cardiol. 2009;46:142-8.
  • 16. Hellenkamp K, Pruszczyk P, Jiménez D, Wyzgał A, Barrios D, Ciurzyński M, et al. Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study. Eur Respir J. 2018;51:1702037.
APA pasli s, Aşık O, Imamoglu M, ÇIÇEK M, Yadigaroglu M, ERDEM S, Menteşe A, SAHIN M, Tatli O (2020). The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism. , 71 - 77. 10.4274/eajem.galenos.2020.92063
Chicago pasli sinan,Aşık Olgun,Imamoglu Melih,ÇIÇEK MUSTAFA,Yadigaroglu Metin,ERDEM SENIZ,Menteşe Ahmet,SAHIN Mursel,Tatli Ozgur The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism. (2020): 71 - 77. 10.4274/eajem.galenos.2020.92063
MLA pasli sinan,Aşık Olgun,Imamoglu Melih,ÇIÇEK MUSTAFA,Yadigaroglu Metin,ERDEM SENIZ,Menteşe Ahmet,SAHIN Mursel,Tatli Ozgur The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism. , 2020, ss.71 - 77. 10.4274/eajem.galenos.2020.92063
AMA pasli s,Aşık O,Imamoglu M,ÇIÇEK M,Yadigaroglu M,ERDEM S,Menteşe A,SAHIN M,Tatli O The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism. . 2020; 71 - 77. 10.4274/eajem.galenos.2020.92063
Vancouver pasli s,Aşık O,Imamoglu M,ÇIÇEK M,Yadigaroglu M,ERDEM S,Menteşe A,SAHIN M,Tatli O The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism. . 2020; 71 - 77. 10.4274/eajem.galenos.2020.92063
IEEE pasli s,Aşık O,Imamoglu M,ÇIÇEK M,Yadigaroglu M,ERDEM S,Menteşe A,SAHIN M,Tatli O "The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism." , ss.71 - 77, 2020. 10.4274/eajem.galenos.2020.92063
ISNAD pasli, sinan vd. "The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism". (2020), 71-77. https://doi.org/10.4274/eajem.galenos.2020.92063
APA pasli s, Aşık O, Imamoglu M, ÇIÇEK M, Yadigaroglu M, ERDEM S, Menteşe A, SAHIN M, Tatli O (2020). The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism. Eurasian Journal of Emergency Medicine, 19(2), 71 - 77. 10.4274/eajem.galenos.2020.92063
Chicago pasli sinan,Aşık Olgun,Imamoglu Melih,ÇIÇEK MUSTAFA,Yadigaroglu Metin,ERDEM SENIZ,Menteşe Ahmet,SAHIN Mursel,Tatli Ozgur The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism. Eurasian Journal of Emergency Medicine 19, no.2 (2020): 71 - 77. 10.4274/eajem.galenos.2020.92063
MLA pasli sinan,Aşık Olgun,Imamoglu Melih,ÇIÇEK MUSTAFA,Yadigaroglu Metin,ERDEM SENIZ,Menteşe Ahmet,SAHIN Mursel,Tatli Ozgur The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism. Eurasian Journal of Emergency Medicine, vol.19, no.2, 2020, ss.71 - 77. 10.4274/eajem.galenos.2020.92063
AMA pasli s,Aşık O,Imamoglu M,ÇIÇEK M,Yadigaroglu M,ERDEM S,Menteşe A,SAHIN M,Tatli O The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism. Eurasian Journal of Emergency Medicine. 2020; 19(2): 71 - 77. 10.4274/eajem.galenos.2020.92063
Vancouver pasli s,Aşık O,Imamoglu M,ÇIÇEK M,Yadigaroglu M,ERDEM S,Menteşe A,SAHIN M,Tatli O The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism. Eurasian Journal of Emergency Medicine. 2020; 19(2): 71 - 77. 10.4274/eajem.galenos.2020.92063
IEEE pasli s,Aşık O,Imamoglu M,ÇIÇEK M,Yadigaroglu M,ERDEM S,Menteşe A,SAHIN M,Tatli O "The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism." Eurasian Journal of Emergency Medicine, 19, ss.71 - 77, 2020. 10.4274/eajem.galenos.2020.92063
ISNAD pasli, sinan vd. "The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism". Eurasian Journal of Emergency Medicine 19/2 (2020), 71-77. https://doi.org/10.4274/eajem.galenos.2020.92063