Pathological findings in acute amitraz intoxication in mice

FİLAZİ, Ayhan; SEKKİN, SELİM; KUM, Cavit; Guvenc, Tolga

Pathological findings in acute amitraz intoxication in mice

Ayhan FİLAZİ, (Ankara Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Tolga GÜVENÇ, (Girilmedi)

Cavit KUM, (Girilmedi)

Selim SEKKİN (Girilmedi)

Turkish Journal of Veterinary and Animal Sciences

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Yıl: 2004 Cilt: 28 Sayı: 5 Sayfa Aralığı: 873 - 878 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Pathological findings in acute amitraz intoxication in mice

Öz:

Bu çalışmada amitraz ve ticari veteriner müstahzarı ile farelerde akut zehirlenme durumlarında doku ve organlardaki hispatolojik bulgular ortaya konulmuştur. Yarısı erkek ve yarısı dişi 312 adet sağlıklı beyaz ingiliz ırkı fareye amitraz müstahzarı 50, 100, 250, 500, 750 and 1000 mg/kg ve teknik amitraz 500, 1000, 1500, 1800, 2200 and 2500 mg/kg dozlarda ağızdan tek sefer verilmiştir. Bir hafta içinde ölen farelerde hemen, ölmeyenler ve kontrol grubundakilerde ötanazi uygulanarak ölüm ağırlıkları, karaciğer ve böbrek ağırlıkları belirlenmiştir. Ayrıca, karaciğer ve böbreklerde de histopatolojik inceleme yapılmıştır. Çalışma sonucunda tek dozda bile amitrazın farelerde kilo kaybına yol açtığı ve ksilenin amitrazın zehirliliğini artırdığı, karaciğer ve böbrek ağırlıklarını değiştirmediği ortaya konulmuştur.

Anahtar Kelime: fareler karaciğer hayvan patolojisi amitraz zehirlenme böbrekler vücut ağırlığı organlar toksisite hayvan dokuları

Konular: Ziraat Mühendisliği

Farelerde akut amitraz zehirlenmelerinde patolojik bulgular

Öz:

This study examined the pathological changes in tissues and organs with acute intoxications with amitraz and its veterinary medicinal formulation. In total 312 healthy white English mice (Mus musculus), 156 female and 156 male, were used for this purpose. The solutions were given to the mice by gavage at the following dosages: 500, 1000, 1500, 1800, 2200 or 2500 mg of technical amitraz/kg and 50, 100, 250, 500, 750 or 1000 mg of amitraz/kg in a veterinary formulation. There was an interval of 1 week after the administration of the study medication. Necropsies were performed immediately on the mice that died during this period and after 7 days on the surviving mice and those in the control group after ether euthanasia. The body weights and liver and kidney weights of all mice were determined. It was observed that amitraz was metabolised in a high degree in the liver, and xylene that was added to the formulations was eliminated from the kidneys and increased the toxicity of amitraz. It was concluded that amitraz caused weight loss in mice.

Anahtar Kelime: organs toxicity animal tissues mice liver animal pathology amitraz poisoning kidneys body weight

Konular: Ziraat Mühendisliği

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	FİLAZİ A, Guvenc T, KUM C, SEKKİN S (2004). Pathological findings in acute amitraz intoxication in mice. , 873 - 878.
Chicago	FİLAZİ Ayhan,Guvenc Tolga,KUM Cavit,SEKKİN SELİM Pathological findings in acute amitraz intoxication in mice. (2004): 873 - 878.
MLA	FİLAZİ Ayhan,Guvenc Tolga,KUM Cavit,SEKKİN SELİM Pathological findings in acute amitraz intoxication in mice. , 2004, ss.873 - 878.
AMA	FİLAZİ A,Guvenc T,KUM C,SEKKİN S Pathological findings in acute amitraz intoxication in mice. . 2004; 873 - 878.
Vancouver	FİLAZİ A,Guvenc T,KUM C,SEKKİN S Pathological findings in acute amitraz intoxication in mice. . 2004; 873 - 878.
IEEE	FİLAZİ A,Guvenc T,KUM C,SEKKİN S "Pathological findings in acute amitraz intoxication in mice." , ss.873 - 878, 2004.
ISNAD	FİLAZİ, Ayhan vd. "Pathological findings in acute amitraz intoxication in mice". (2004), 873-878.

APA	FİLAZİ A, Guvenc T, KUM C, SEKKİN S (2004). Pathological findings in acute amitraz intoxication in mice. Turkish Journal of Veterinary and Animal Sciences, 28(5), 873 - 878.
Chicago	FİLAZİ Ayhan,Guvenc Tolga,KUM Cavit,SEKKİN SELİM Pathological findings in acute amitraz intoxication in mice. Turkish Journal of Veterinary and Animal Sciences 28, no.5 (2004): 873 - 878.
MLA	FİLAZİ Ayhan,Guvenc Tolga,KUM Cavit,SEKKİN SELİM Pathological findings in acute amitraz intoxication in mice. Turkish Journal of Veterinary and Animal Sciences, vol.28, no.5, 2004, ss.873 - 878.
AMA	FİLAZİ A,Guvenc T,KUM C,SEKKİN S Pathological findings in acute amitraz intoxication in mice. Turkish Journal of Veterinary and Animal Sciences. 2004; 28(5): 873 - 878.
Vancouver	FİLAZİ A,Guvenc T,KUM C,SEKKİN S Pathological findings in acute amitraz intoxication in mice. Turkish Journal of Veterinary and Animal Sciences. 2004; 28(5): 873 - 878.
IEEE	FİLAZİ A,Guvenc T,KUM C,SEKKİN S "Pathological findings in acute amitraz intoxication in mice." Turkish Journal of Veterinary and Animal Sciences, 28, ss.873 - 878, 2004.
ISNAD	FİLAZİ, Ayhan vd. "Pathological findings in acute amitraz intoxication in mice". Turkish Journal of Veterinary and Animal Sciences 28/5 (2004), 873-878.