TY  - JOUR
TI  - Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?
AB  - Studies reported that phosphodiesterase-5 inhibitors (PDE-5Is) positively contributed to bone-mineral-density and thickness inrats with ovariectomy, which have the same condition with postmenapozal period. To explain the positive contributionmechanism on bone mineral density of PDE-5Is, we investigated the effect of zaprinast and avanafil on levels of some pro -oranti-resorptive cytokines in ovariectomized-rats.Albino female rats (8 months and 250-350 g) were used and four groups of equal-number were randomly assigned (n=6). Groups;was the sahm operated, positive control (OVX), Zaprinast and OVX, Avanafil and OVX groups, respectively. The levels ofEstrogen, IL-1β, IL-6, IL-8, IL-10 and TNF-α were measured by ELISA kits, in liver of rats.IL-1β, IL-6, IL-8 and TNF-α levels were high in groups with OVX compared to sham group, while IL-10 levels were low. Also,IL-1β, IL-6, IL-8 and TNF-α levels were low in zaprinast and especially avanafil-treated groups with OVX and were similar to thesahm group values (p=0.001 for IL-1β, p=0.045 for IL-6, p=0.008 for IL-8, p=0.006 for IL-10, p=0.026 for TNF-α).Zaprinast and especially avanafil inhibited IL-1β, 8 and TNF-α and increased the IL-10 levels compared to the OVX group. Thismay support opinion that PDE-5Is enhance bone mineralization by inhibiting proresorptive cytokines.
AU  - Bakan, Nuri
AU  - ÇOKLUK, erdem
AU  - alp, hamit hakan
AU  - Şekeroğlu, Mehmet Ramazan
AU  - Huyut, Zübeyir
AU  - AKBAY, HALİL İBRAHİM
DO  - 10.5505/ejm.2020.57689
PY  - 2020
JO  - Eastern Journal of Medicine
VL  - 25
IS  - 3
SN  - 1301-0883
SP  - 383
EP  - 387
DB  - TRDizin
UR  - http://search/yayin/detay/377221
ER  -