TY  - JOUR
TI  - Local Bone Marrow Renin-Angiotensin System and COVID-19
AB  - For the first time on December 31, 2019, 27 cases of pneumonia of unknown etiology were detected in Wuhan City, Hubei province,China. The factor that caused this clinic was called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In the following days, WHO officially named the disease caused by the new coronavirus as Coronavirus Disease 2019 (COVID-19). Patientsinfected with SARS-CoV-2 mostly applied to health centers with symptoms of dry cough, shortness of breath and fever. some patientshave developed death-causing complications such as organ failure, septic shock, pulmonary edema, severe pneumonia, and AcuteRespiratory Distress Syndrome (ARDS). SARS-CoV-2 infects patients by binding human Angiotensin Converting Enzyme 2 (ACE 2),causing to severe pneumonia and high mortality. Circulating RAS and local paracrin-autocrin-intracrin tissue-based RAS participatein numerous pathobiological events. Pro-inflammatory, pro-fibrotic, and pro-thrombotic consequences associated with local RASactivation have been detected at cellular and molecular level. Regenerative progenitor cell therapy in response to RAS-modulatingpharmacotherapy in context of endothelial cell damage and regeneration emerged as an auxiliary therapy to improve regeneration ofthe vascular endothelium. The aim of this article is to evaluate the relationship between circulating and local angiotensin systems andCOVID-19
AU  - Ciftciler, Ali Erdinc
AU  - Haznedaroglu, Ibrahim C.
AU  - Çiftçiler, Rafiye
DO  - 10.4999/uhod.204171
PY  - 2020
JO  - Uluslararası Hematoloji-Onkoloji Dergisi
VL  - 30
IS  - 2
SN  - 1306-133X
SP  - 113
EP  - 120
DB  - TRDizin
UR  - http://search/yayin/detay/377857
ER  -