Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters

Çağlar MACİT, (İstanbul Medipol Üniversitesi, Eczacılık Fakültesi,Farmakoloji Anabilim Dalı, İstanbul, Türkiye.)
Ünsal Veli ÜSTÜNDAĞ, (İstanbul Medipol Üniversitesi,Tıp Fakültesi,Biyokimya Anabilim Dalı, İstanbul,Türkiye.)
OZAN EMRE EYUPOĞLU, (İstanbul Medipol Üniversitesi,Tıp Fakültesi,Biyokimya Anabilim Dalı, İstanbul,Türkiye.)
ÖZGE ÇEVİK, (İstanbul Medipol Üniversitesi,Tıp Fakültesi,Biyokimya Anabilim Dalı, İstanbul,Türkiye.)
Göksel ŞENER (Adnan Menderes Üniversitesi, Tıp Fakültesi,Biyokimya Anabilim Dalı, Aydın,Türkiye)
Journal of research in pharmacy (online)
0 0
Yıl: 2020 Cilt: 24 Sayı: 1 Sayfa Aralığı: 121 - 132 Metin Dili: İngilizce DOI: 10.35333/jrp.2020.118 İndeks Tarihi: 19-11-2020

Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters

Öz:
Aging is a progressive and catabolic process by cells of the body are broken down.Study scrutinized the effects of exercise and caloric restriction in cardiovascular hemodynamics and antioxidant system parameters. Rats divided to 5 categories as 1 control group (including 3 months aged animals) and 4 test groups (including 15 months aged animals) named by A-SED (aged-sedentary), A-CR (aged-caloric restricted), A-EX (aged-exercised) and A-CR-EX (aged-(exercised+caloric restricted)) created by adding carbachol(CAR) and phenylephrine (PE) cumulatively and during 6 weeks, 40% caloric restriction and swimming were administered to aged animals. At the beginning and end of study, blood pressure (BP) and ECHO of the animals were measured. After decapitation process, tissue (heart and aorta) samples were collected. In tissue samples, apoptotic and oxidative stress parameters, and in blood samples NO levels were studied. Additionally, tissues were viewed as histologically at light microscopy. GraphPadPrism 5v. program was used for statistics and p<0.05 were considered significantly. Contraction-relaxation responses of aorta improved after CR and EX administrations (p<0.05). In both tissues, oxidative stress parameters (8-OHdG, MDA, SOD, GSH), caspase-3 activity and caspase-3 dansity were recovered meaningfully (p<0.05). Finally, NO levels were significantly recovered with CR and EX administrations in aged animals (p<0.05). To sum up, it is suggested that CR and EX administrations contribute to the recovery of hemodynamic and antioxidant system parameters in aged rats.
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APA macit c, Ustundag U, EYUPOĞLU O, Cevik O, Şener G (2020). Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters. , 121 - 132. 10.35333/jrp.2020.118
Chicago macit caglar,Ustundag Unsal Veli,EYUPOĞLU Ozan Emre,Cevik Ozge,Şener Göksel Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters. (2020): 121 - 132. 10.35333/jrp.2020.118
MLA macit caglar,Ustundag Unsal Veli,EYUPOĞLU Ozan Emre,Cevik Ozge,Şener Göksel Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters. , 2020, ss.121 - 132. 10.35333/jrp.2020.118
AMA macit c,Ustundag U,EYUPOĞLU O,Cevik O,Şener G Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters. . 2020; 121 - 132. 10.35333/jrp.2020.118
Vancouver macit c,Ustundag U,EYUPOĞLU O,Cevik O,Şener G Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters. . 2020; 121 - 132. 10.35333/jrp.2020.118
IEEE macit c,Ustundag U,EYUPOĞLU O,Cevik O,Şener G "Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters." , ss.121 - 132, 2020. 10.35333/jrp.2020.118
ISNAD macit, caglar vd. "Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters". (2020), 121-132. https://doi.org/10.35333/jrp.2020.118
APA macit c, Ustundag U, EYUPOĞLU O, Cevik O, Şener G (2020). Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters. Journal of research in pharmacy (online), 24(1), 121 - 132. 10.35333/jrp.2020.118
Chicago macit caglar,Ustundag Unsal Veli,EYUPOĞLU Ozan Emre,Cevik Ozge,Şener Göksel Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters. Journal of research in pharmacy (online) 24, no.1 (2020): 121 - 132. 10.35333/jrp.2020.118
MLA macit caglar,Ustundag Unsal Veli,EYUPOĞLU Ozan Emre,Cevik Ozge,Şener Göksel Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters. Journal of research in pharmacy (online), vol.24, no.1, 2020, ss.121 - 132. 10.35333/jrp.2020.118
AMA macit c,Ustundag U,EYUPOĞLU O,Cevik O,Şener G Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters. Journal of research in pharmacy (online). 2020; 24(1): 121 - 132. 10.35333/jrp.2020.118
Vancouver macit c,Ustundag U,EYUPOĞLU O,Cevik O,Şener G Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters. Journal of research in pharmacy (online). 2020; 24(1): 121 - 132. 10.35333/jrp.2020.118
IEEE macit c,Ustundag U,EYUPOĞLU O,Cevik O,Şener G "Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters." Journal of research in pharmacy (online), 24, ss.121 - 132, 2020. 10.35333/jrp.2020.118
ISNAD macit, caglar vd. "Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascularhemodynamicandantioxidantsystem parameters". Journal of research in pharmacy (online) 24/1 (2020), 121-132. https://doi.org/10.35333/jrp.2020.118
Sayfa Oluşturulma Tarihi
23-04-2024 15:14

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