Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking

Altuntas, Tunca Gul; Baydar, Aziz; Kilic-Kurt, Zühal; Acar, Cemre; Yilmaz-Sarialtin, Sezen; Coban, Tulay

doi:10.35333/jrp.2020.157

Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking

Tunca Gül ALTUNTAŞ, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)

Aziz BAYDAR, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)

Zühal KILIÇ-KURT, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)

Cemre ACAR, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)

SEZEN YILMAZ SARIALTIN, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Tülay ÇOBAN (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Journal of research in pharmacy (online)

16 0

Yıl: 2020 Cilt: 24 Sayı: 3 Sayfa Aralığı: 350 - 360 Metin Dili: İngilizce DOI: 10.35333/jrp.2020.157 İndeks Tarihi: 19-11-2020

Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking

Öz:

In this work, a series of piperazine substituted indole derivatives were synthesized and evaluated for theirin vitro antioxidant and anti-inflammatory activities. The results of antioxidant activity showed that compounds 2(81.63%) and 11 (85.63%) had comparable DPPH free radical scavenging activity to Vit E (88.6%). The in vitro antiinflammatory assays indicated that most of the compounds had more higher anti-inflammatory activities than standartASA. Docking results revealed that compound 11 possessing the strongest anti-inflammatory activities showed the Hbond interactions with the key residues of COX-2 active site. It suggested that the anti-inflammatory activity of thecompounds might result from COX-2 inhibition. It will be verified with further enzyme inhibition assays.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Altuntas T, Baydar A, Kilic-Kurt Z, Acar C, Yilmaz-Sarialtin S, Coban T (2020). Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking. , 350 - 360. 10.35333/jrp.2020.157
Chicago	Altuntas Tunca Gul,Baydar Aziz,Kilic-Kurt Zühal,Acar Cemre,Yilmaz-Sarialtin Sezen,Coban Tulay Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking. (2020): 350 - 360. 10.35333/jrp.2020.157
MLA	Altuntas Tunca Gul,Baydar Aziz,Kilic-Kurt Zühal,Acar Cemre,Yilmaz-Sarialtin Sezen,Coban Tulay Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking. , 2020, ss.350 - 360. 10.35333/jrp.2020.157
AMA	Altuntas T,Baydar A,Kilic-Kurt Z,Acar C,Yilmaz-Sarialtin S,Coban T Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking. . 2020; 350 - 360. 10.35333/jrp.2020.157
Vancouver	Altuntas T,Baydar A,Kilic-Kurt Z,Acar C,Yilmaz-Sarialtin S,Coban T Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking. . 2020; 350 - 360. 10.35333/jrp.2020.157
IEEE	Altuntas T,Baydar A,Kilic-Kurt Z,Acar C,Yilmaz-Sarialtin S,Coban T "Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking." , ss.350 - 360, 2020. 10.35333/jrp.2020.157
ISNAD	Altuntas, Tunca Gul vd. "Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking". (2020), 350-360. https://doi.org/10.35333/jrp.2020.157

APA	Altuntas T, Baydar A, Kilic-Kurt Z, Acar C, Yilmaz-Sarialtin S, Coban T (2020). Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking. Journal of research in pharmacy (online), 24(3), 350 - 360. 10.35333/jrp.2020.157
Chicago	Altuntas Tunca Gul,Baydar Aziz,Kilic-Kurt Zühal,Acar Cemre,Yilmaz-Sarialtin Sezen,Coban Tulay Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking. Journal of research in pharmacy (online) 24, no.3 (2020): 350 - 360. 10.35333/jrp.2020.157
MLA	Altuntas Tunca Gul,Baydar Aziz,Kilic-Kurt Zühal,Acar Cemre,Yilmaz-Sarialtin Sezen,Coban Tulay Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking. Journal of research in pharmacy (online), vol.24, no.3, 2020, ss.350 - 360. 10.35333/jrp.2020.157
AMA	Altuntas T,Baydar A,Kilic-Kurt Z,Acar C,Yilmaz-Sarialtin S,Coban T Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking. Journal of research in pharmacy (online). 2020; 24(3): 350 - 360. 10.35333/jrp.2020.157
Vancouver	Altuntas T,Baydar A,Kilic-Kurt Z,Acar C,Yilmaz-Sarialtin S,Coban T Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking. Journal of research in pharmacy (online). 2020; 24(3): 350 - 360. 10.35333/jrp.2020.157
IEEE	Altuntas T,Baydar A,Kilic-Kurt Z,Acar C,Yilmaz-Sarialtin S,Coban T "Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking." Journal of research in pharmacy (online), 24, ss.350 - 360, 2020. 10.35333/jrp.2020.157
ISNAD	Altuntas, Tunca Gul vd. "Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking". Journal of research in pharmacy (online) 24/3 (2020), 350-360. https://doi.org/10.35333/jrp.2020.157