TY  - JOUR
TI  - The association of clinicopathologic features and peripheral blood parameters with high PD-L1 expression in non-small cell lung cancer
AB  - Introduction: Programmed death ligand 1 (PD-L1) is a marker that widelyused for prediction of response to immunotherapy. Dynamic alteration ofPD-L1 expression are the major problems for reflection of the actual status ofthe PD-L1. So, we aimed to investigate the factors that may be associated withPD-L1 expression in lung cancer.Materials and Methods: The patients diagnosed with non-small cell lung cancer were enrolled, retrospectively. The patients were stratified according toPD-L1 expression level as ≥ 50% and < 50%.Results: Totally, 217 patients were enrolled. The clinicopathologic featureswere similar between two groups, except the amount of cigarette consumption. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and systemicimmune-inflammmotry index were found significantly lower in PD-L1 ≥ 50%(p< 0.001, p= 0.006 and p= 0.003, respectively) and also negatively correlated with PD-L1 level (rho= -0.255, p< 0.001; rho= -0.17, p= 0.013; rho= -0.185, p= 0.006, respectively)Conclusion: According to the results of our study, peripheral blood parameters can be used to the prediction of the high PD-L1expression and can be used for reflection of current PD-L1 expression.
AU  - YILMAZ, ÜLKÜ
AU  - BILGIN, BURAK
AU  - Yücel, Şebnem
AU  - Akinci, Muhammed Bulent
AU  - Sendur, Mehmet
AU  - yalcin, bulent
AU  - Hizal, Mutlu
AU  - Akyurek, Nalan
DO  - 10.5578/tt.69182
PY  - 2020
JO  - Tüberküloz ve Toraks
VL  - 68
IS  - 2
SN  - 0494-1373
SP  - 118
EP  - 125
DB  - TRDizin
UR  - http://search/yayin/detay/378798
ER  -