New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies

Naga Raju CHAMARTHİ, (Sri Venkateswara University,Department of Chemistry,Andhra Pradesh, India)
Venkata Chalapathi PONNE, (Sri Venkateswara Arts College (TTD’s),Department of Chemistry, Andhra Pradesh, India)
Hari Babu PULLURU, (Sri Venkateswara Arts College (TTD’s),Department of Chemistry, Andhra Pradesh, India)
Janakiramudu Dasari BALİJA, (Sri Venkateswara Arts College (TTD’s),Department of Chemistry, Andhra Pradesh, India)
Sindhu Reddy GUTALA, (Sri Venkateswara University,Department of Future Studies/Biotechnology, Andhra Pradesh, India)
Saritha Venkatareddy KALLİMAKULA, (Sri Venkateswara University,Department of Future Studies/Biotechnology, Andhra Pradesh, India)
Venkataramaiah CHİNTHA, (Sri Venkateswara University,Division of Molecular Biology, Department of Zoology, Andhra Pradesh, India)
Rajendra WUDAYAGİRİ (Sri Venkateswara University,Division of Molecular Biology, Department of Zoology, Andhra Pradesh, India)
Organic Communications
3 0
Yıl: 2018 Cilt: 11 Sayı: 2 Sayfa Aralığı: 80 - 97 Metin Dili: İngilizce DOI: 10.25135/acg.oc.41.18.03.069 İndeks Tarihi: 24-11-2020

New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies

Öz:
A family of bisurea derivatives of 4,4′-methylenebis(phenyl isocyanate) have been synthesized with simple, effective and efficient procedure in high yields. The new compounds showed moderate bioactivity (at 32.0 μ g/μ L concentration) against selected bacterial pathogens, viz., Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa; and two fungal species, Candida albicans and Cryptococcus neoformans var. grubii. Alternatively, their antioxidant activity was also evaluated by DPPH radical scavenging assay which revealed that the compounds, 10d, 10e, 10h and 10m exhibited moderate activity. However, the molecular docking studies of all the title compounds showed surprisingly higher binding energies with DNA gyrase A protein of E. coli when compared to the reference, streptomycin. Among the compounds 10e, 10f, 10g, 10k,10l and 10m showed very good binding energies which implied that they could be promising next generation antimicrobials.
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APA CHAMARTHİ N, PONNE V, PULLURU H, BALİJA J, GUTALA S, KALLİMAKULA S, CHİNTHA V, WUDAYAGİRİ R (2018). New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies. , 80 - 97. 10.25135/acg.oc.41.18.03.069
Chicago CHAMARTHİ Naga Raju,PONNE Venkata Chalapathi,PULLURU Hari Babu,BALİJA Janakiramudu Dasari,GUTALA Sindhu Reddy,KALLİMAKULA Saritha Venkatareddy,CHİNTHA Venkataramaiah,WUDAYAGİRİ Rajendra New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies. (2018): 80 - 97. 10.25135/acg.oc.41.18.03.069
MLA CHAMARTHİ Naga Raju,PONNE Venkata Chalapathi,PULLURU Hari Babu,BALİJA Janakiramudu Dasari,GUTALA Sindhu Reddy,KALLİMAKULA Saritha Venkatareddy,CHİNTHA Venkataramaiah,WUDAYAGİRİ Rajendra New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies. , 2018, ss.80 - 97. 10.25135/acg.oc.41.18.03.069
AMA CHAMARTHİ N,PONNE V,PULLURU H,BALİJA J,GUTALA S,KALLİMAKULA S,CHİNTHA V,WUDAYAGİRİ R New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies. . 2018; 80 - 97. 10.25135/acg.oc.41.18.03.069
Vancouver CHAMARTHİ N,PONNE V,PULLURU H,BALİJA J,GUTALA S,KALLİMAKULA S,CHİNTHA V,WUDAYAGİRİ R New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies. . 2018; 80 - 97. 10.25135/acg.oc.41.18.03.069
IEEE CHAMARTHİ N,PONNE V,PULLURU H,BALİJA J,GUTALA S,KALLİMAKULA S,CHİNTHA V,WUDAYAGİRİ R "New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies." , ss.80 - 97, 2018. 10.25135/acg.oc.41.18.03.069
ISNAD CHAMARTHİ, Naga Raju vd. "New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies". (2018), 80-97. https://doi.org/10.25135/acg.oc.41.18.03.069
APA CHAMARTHİ N, PONNE V, PULLURU H, BALİJA J, GUTALA S, KALLİMAKULA S, CHİNTHA V, WUDAYAGİRİ R (2018). New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies. Organic Communications, 11(2), 80 - 97. 10.25135/acg.oc.41.18.03.069
Chicago CHAMARTHİ Naga Raju,PONNE Venkata Chalapathi,PULLURU Hari Babu,BALİJA Janakiramudu Dasari,GUTALA Sindhu Reddy,KALLİMAKULA Saritha Venkatareddy,CHİNTHA Venkataramaiah,WUDAYAGİRİ Rajendra New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies. Organic Communications 11, no.2 (2018): 80 - 97. 10.25135/acg.oc.41.18.03.069
MLA CHAMARTHİ Naga Raju,PONNE Venkata Chalapathi,PULLURU Hari Babu,BALİJA Janakiramudu Dasari,GUTALA Sindhu Reddy,KALLİMAKULA Saritha Venkatareddy,CHİNTHA Venkataramaiah,WUDAYAGİRİ Rajendra New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies. Organic Communications, vol.11, no.2, 2018, ss.80 - 97. 10.25135/acg.oc.41.18.03.069
AMA CHAMARTHİ N,PONNE V,PULLURU H,BALİJA J,GUTALA S,KALLİMAKULA S,CHİNTHA V,WUDAYAGİRİ R New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies. Organic Communications. 2018; 11(2): 80 - 97. 10.25135/acg.oc.41.18.03.069
Vancouver CHAMARTHİ N,PONNE V,PULLURU H,BALİJA J,GUTALA S,KALLİMAKULA S,CHİNTHA V,WUDAYAGİRİ R New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies. Organic Communications. 2018; 11(2): 80 - 97. 10.25135/acg.oc.41.18.03.069
IEEE CHAMARTHİ N,PONNE V,PULLURU H,BALİJA J,GUTALA S,KALLİMAKULA S,CHİNTHA V,WUDAYAGİRİ R "New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies." Organic Communications, 11, ss.80 - 97, 2018. 10.25135/acg.oc.41.18.03.069
ISNAD CHAMARTHİ, Naga Raju vd. "New symmetrical acyclic and alicyclic bisureaderivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies". Organic Communications 11/2 (2018), 80-97. https://doi.org/10.25135/acg.oc.41.18.03.069
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23-04-2024 15:23

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