TY  - JOUR
TI  - Tear Ozmolarity in the Evaluation of Ankylosing Spondylitis Disease Activity
AB  - Objective: To investigate the frequency of dry eye syndrome (DES) in patients with ankylosingspondylitis (AS) by measuring tear osmolarity (TO) with the recently introduced TearLab system(TearLab Corp, San Diego, Calif.) and to determine the relationship between the severity of DE andAS activity.Materials and Methods: Fifty-seven eyes of 57 patients and 29 healthy individuals as the controlgroup were included. TO measurements, tear break-up time (BUT), and Schirmer’s tests wereperformed. The patients were divided into three main groups based on their Bath AnkylosingSpondylitis Disease Activity Index (BASDAI) scores: healthy controls, mild-moderate (BASDAI ≤ 4),and severe (BASDAI>4) , into another group based on HLA B27 status: control, HLA B27 (+) and(-), finally based on treatment status: control, treatment (+) and (-).Results: There were no significant differences based on BASDAI among these subgroups in termsof TO (P= 0.383), BUT (P= 0.722) and Schirmer’s scores (P= 0.108). Also disease activity scorevalues were not correlated with TO values ( r=0,23, P=0,863), Schirmer’s scores (r= –0.223, P=0.095) and BUT scores (r = –0.044, P= 0.744).Conclusion: In our study, we determined higher TO values in non-treated, HLA-B27 markerpositive and high disease activity groups. Although these values did not reach statisticalsignificance, our findings suggest that in high inflammatory levels, TO can be utilized as apreliminary marker for AS disease activity.
AU  - Fındık, Hüseyin
AU  - Okutucu, Murat
AU  - KOÇ, Hacı İbrahim
AU  - Aslan, Mehmet Gökhan
AU  - Serdaroğlu Beyazal, Münevver
AU  - Ekici, Feyzahan
PY  - 2020
JO  - Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
VL  - 34
IS  - 1
SN  - 1308-9315
SP  - 49
EP  - 54
DB  - TRDizin
UR  - http://search/yayin/detay/379577
ER  -