Yıl: 2020 Cilt: 12 Sayı: 3 Sayfa Aralığı: 303 - 307 Metin Dili: İngilizce DOI: 10.4274/jcrpe.galenos.2020.2019.0186 İndeks Tarihi: 25-11-2020

Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study

Öz:
Increased intestinal permeability (IIP) precedes several autoimmune disorders. Although Hashimoto’s thyroiditis (HT) is the mostcommon autoimmune disorder, the role of IIP in its pathogenesis had received little attention. Zonulin plays a critical role in IIP bymodulating intracellular tight junctions. Rise of serum zonulin levels were shown to indicate IIP in human subjects. In this case-controlstudy, we examined the hypothesis that patients with HT have IIP. We studied 30 children and adolescents with HT, and 30 patients withcongenital hypothyroidism (CH) matched for age, gender and body mass index (BMI). Serum zonulin levels, free thyroxine (fT4), thyroidstimulating hormone (TSH), anti-thyroglobulin antibody and anti-thyroid peroxidase antibody were measured. Zonulin levels weresignificantly higher in patients with HT than patients with CH (59.1±22.9 ng/mL vs. 43.3±32.9 ng/mL, p=0.035). In patients with HT,zonulin levels were positively correlated with weight (r=0.406, p=0.03), BMI (r=0.486, p=0.006) and levothyroxine dose (r=0.463,p=0.02). In patients with CH, zonulin levels were positively correlated with age (r=0.475, p=0.008), weight (r=0.707, p<0.001), BMI(r=0.872, p<0.001) and levothyroxine dose (r=0.485, p=0.007). After adjusting for age, weight, TSH and fT4 levels, serum zonulinwas only associated with levothyroxine dose in patients with HT (R2=0.36, p=0.05). In patients with CH, only weight was associatedwith zonulin levels (R2=0.62, p<0.001). In conclusion, higher zonulin levels in children and adolescents with HT suggested IIP in thesepatients. Additionally, the association between zonulin levels and levothyroxine dose might imply a relationship between serum zonulinand disease severity
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APA Aydin B, Yildiz M, akgün a, Topal N, Adal E, Onal H (2020). Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study. , 303 - 307. 10.4274/jcrpe.galenos.2020.2019.0186
Chicago Aydin Banu,Yildiz Melek,akgün abdurrahman,Topal Neval,Adal Erdal,Onal Hasan Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study. (2020): 303 - 307. 10.4274/jcrpe.galenos.2020.2019.0186
MLA Aydin Banu,Yildiz Melek,akgün abdurrahman,Topal Neval,Adal Erdal,Onal Hasan Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study. , 2020, ss.303 - 307. 10.4274/jcrpe.galenos.2020.2019.0186
AMA Aydin B,Yildiz M,akgün a,Topal N,Adal E,Onal H Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study. . 2020; 303 - 307. 10.4274/jcrpe.galenos.2020.2019.0186
Vancouver Aydin B,Yildiz M,akgün a,Topal N,Adal E,Onal H Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study. . 2020; 303 - 307. 10.4274/jcrpe.galenos.2020.2019.0186
IEEE Aydin B,Yildiz M,akgün a,Topal N,Adal E,Onal H "Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study." , ss.303 - 307, 2020. 10.4274/jcrpe.galenos.2020.2019.0186
ISNAD Aydin, Banu vd. "Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study". (2020), 303-307. https://doi.org/10.4274/jcrpe.galenos.2020.2019.0186
APA Aydin B, Yildiz M, akgün a, Topal N, Adal E, Onal H (2020). Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study. Journal of Clinical Research in Pediatric Endocrinology, 12(3), 303 - 307. 10.4274/jcrpe.galenos.2020.2019.0186
Chicago Aydin Banu,Yildiz Melek,akgün abdurrahman,Topal Neval,Adal Erdal,Onal Hasan Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study. Journal of Clinical Research in Pediatric Endocrinology 12, no.3 (2020): 303 - 307. 10.4274/jcrpe.galenos.2020.2019.0186
MLA Aydin Banu,Yildiz Melek,akgün abdurrahman,Topal Neval,Adal Erdal,Onal Hasan Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study. Journal of Clinical Research in Pediatric Endocrinology, vol.12, no.3, 2020, ss.303 - 307. 10.4274/jcrpe.galenos.2020.2019.0186
AMA Aydin B,Yildiz M,akgün a,Topal N,Adal E,Onal H Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study. Journal of Clinical Research in Pediatric Endocrinology. 2020; 12(3): 303 - 307. 10.4274/jcrpe.galenos.2020.2019.0186
Vancouver Aydin B,Yildiz M,akgün a,Topal N,Adal E,Onal H Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study. Journal of Clinical Research in Pediatric Endocrinology. 2020; 12(3): 303 - 307. 10.4274/jcrpe.galenos.2020.2019.0186
IEEE Aydin B,Yildiz M,akgün a,Topal N,Adal E,Onal H "Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study." Journal of Clinical Research in Pediatric Endocrinology, 12, ss.303 - 307, 2020. 10.4274/jcrpe.galenos.2020.2019.0186
ISNAD Aydin, Banu vd. "Children with Hashimoto’s Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study". Journal of Clinical Research in Pediatric Endocrinology 12/3 (2020), 303-307. https://doi.org/10.4274/jcrpe.galenos.2020.2019.0186