TY  - JOUR
TI  - The Effiacy of Continuous Venovenous Hemodiafitration with Cytokine Filter on Sepsis
AB  - Objective: Continuous renal replacement therapy is made with high biocompatibility membranes that have high currentpower by using diffusion and convection together or separately. The aim of the present study was to compare the EMIC-2and AV600S filters used for continuous venovenous hemodiafiltration (CVVHDF) with respect to the effects on sepsis, theelimination of toxins that are elevated due to acute renal injury, and the effects on inflammatory mediators in severe sepsis.Materials and Methods: The study included 38 patients who were diagnosed with severe sepsis and were treated withhemodiafiltration in the intensive care unit. Acute Physiology and Chronic Health Evaluation—2 (APACHE-2) and SequentialOrgan Failure Assessment (SOFA) scores of the patients were calculated before CVVHDF starts. Hematocrit (Hct), whiteblood cell, blood pressure, heart rate, and body temperature values were measured and recorded. Procalcitonin (PCT), tumornecrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-1 values on blood were also recorded before the process and at 8,16, and 24 h of the process.Results: When the AV600S filtered and EMIC-2 filtered groups are compared, TNF-α values are low in the EMIC-2 filteredgroup (p<0.05). There is no significant difference between the groups with respect to the measurements about APACHE-2,SOFA, IL-1β, IL-6, PCT, Hct, body temperature, mean blood pressures, and heart rate.Conclusion: We think that the filters do not cause a significant change on the elimination of inflammatory cytokines, exceptTNF-α, on limited numbers of patients who have sepsis with acute renal injury undergoing CVVHDF with EMIC-2 and AV600S.
AU  - Gülsoy, Zuhal
AU  - GÜRSOY, Sinan
AU  - ÖZDEMİR KOL, İCLAL
AU  - KAYGUSUZ, KENAN
AU  - AVCI, Serdar Onur
AU  - YILDIRIM, Mehtap
DO  - 10.14744/etd.2019.22599
PY  - 2020
JO  - Erciyes Medical Journal
VL  - 42
IS  - 1
SN  - 2149-2247
SP  - 54
EP  - 59
DB  - TRDizin
UR  - http://search/yayin/detay/380506
ER  -