TY  - JOUR
TI  - Assessment of Post-transplantation Liver Function Tests in Patients Undergoing Allogeneic Stem Cell Transplantation
AB  - Objective: Allogeneic hematopoietic stem cell transplantation is a treatment with a considerable rate of complete cure inhematological disorders. Hepatic complications are common causes of morbidity and mortality affecting the survival afterstem cell transplantation. This study was conducted to identify risk factors for hepatic dysfunction and related potential factorsaffecting the survival in patients undergoing allogeneic hematopoietic stem cell transplantation.Materials and Methods: We retrospectively evaluated the data from 300 allogeneic hematopoietic stem cell transplantationrecipients between March 2004 and May 2014 in the Erciyes University Hematology and Bone Marrow TransplantationCenter, Turkey. The study included 300 patients and their serial monitorization of the liver function tests, examined beforeand after transplantation.Results: The transplantation in 30 patients was performed from haploidentical donors and in 13 patients from unrelateddonors. We identified the liver function abnormalities in 71.7% of patients in the post-transplantation period. The mostcommon causes were graft-versus-host disease (43.6%), drug toxicity (24.7%), and sepsis (13.9%). Post-transplantation liverabnormalities were more common in patients with acute leukemia (p=0.02), iron overload (p<0.001), and in those who alsohad transaminitis in the pretransplantation period (p<0.001). Relapsed underlying disease (p<0.001), iron overload, anda bilirubin level >2 mg/dL in association with hepatic dysfunction during the post-transplantation period were identified asmajor factors influencing mortality following transplantation (p<0.001).Conclusion: We concluded that liver function abnormalities are frequent in the hematopoietic stem cell transplantationprocess. For a successful management, it is important to monitor the liver function and to identify additional risk factorsbefore and after transplantation.
AU  - Eser, Bülent
AU  - Yildizhan, Esra
AU  - ÇETİN, Mustafa Alp
AU  - ÜNAL, Ali Tamer
AU  - Kaynar, Leylagul
AU  - kızıltepe, melih
DO  - 10.14744/etd.2019.26986
PY  - 2020
JO  - Erciyes Medical Journal
VL  - 42
IS  - 1
SN  - 2149-2247
SP  - 60
EP  - 65
DB  - TRDizin
UR  - http://search/yayin/detay/380507
ER  -