Yıl: 2020 Cilt: 20 Sayı: 1 Sayfa Aralığı: 47 - 56 Metin Dili: İngilizce DOI: 10.5505/amj.2020.71542

EVALUATION OF THIOL DISULPHIDE HOMEOSTASIS AND NEUTROPHILE LYMPHOCYTE RATIO IN CARBON MONOXIDE INTOXICATION

Öz:
Objectives: The aim of this study is to search if using thiol/disulphide homeostasis together with Neutrophile Lymphocyte Ratio (NLR) which are oxidative stress markers in patients who apply to the emergency service with carbon monoxide intoxication is useful regarding diagnosis or not. Materials and Methods: The study was performed prospectively with 45 patients who applied to the emergency service between 01.01.2014 - 01.03.2015 and who were included in the study and 40 healthy persons who were determined as control group. Thiol/disulphide homeostasis parameters (Thiol, disulphide, disulphide / native thiol, disulphide / total thiol, native thiol / total thiol) and NLR which are oxidative stress markers were studied in the patient and control groups by a method which was developed newly by Erel and Neşelioğlu. Results: In persons with carbon monoxide intoxication, a significant difference was detected in NT, TT, index 3 and NLR rates according to the control group. NT, TT and index 3 were found lower in the patient group, and NLR mean values were found higher in the patient group (p =0.005, < 0.001, = 0.032, < 0.001 respectively). Conclusion: To use NLR together with thiol/disulphide homeostasis parameters in the diagnosis of carbon monoxide intoxication is useful regarding diagnosing in these patients.
Anahtar Kelime:

KARBONMONOKSİT ZEHİRLENMESİNDE THİOL DİSULFİD HOMEOSTAZİSİ VE NÖTROFİL LENFOSİT ORANI DEĞERLENDİRİLMESİ

Öz:
Amaç: Bu çalışmanın amacı acil servise karbon monoksit zehirlenmesi nedeniyle başvuran hastalarda oksidatif stres markerlarından olan thiol/disülfit homeostazis parametreleri ile Nötrofil-Lenfosit (NLO) beraber kullanımının tanı açısından yararlı olup olmadığını araştırmaktır. Materyal ve Metot: Çalışma 01.01.2014 ile 01.03.2015 tarihleri arasında acil servise başvuran ve çalışmaya alınan 45 hasta ve kontrol grubu olarak belirlenen 40 sağlıklı kişi ile prospektif olarak yapıldı. Erel ve Neşelioğlu tarafından yeni geliştirilen bir metot ile oksidatif stres markerı olan thiol/disülfit homeostazis parametreleri (Thiol, disülfit, disülfit/native thiol, disülfit/total thiol, native thiol/total thiol) ile NLO hasta ve kontrol grubunda çalışıldı. Bulgular: Karbonmonoksit zehirlenmesi olanlarda kontrol grubuna göre, NT, TT, index 3 ve NLO oranlarında anlamlı farklılık tespit edildi. NT, TT ve index 3 hasta grubunda daha düşük, NLO ortalama değerleri daha yüksek bulundu (sırasıyla p =0,005; < 0,001; < 0,032 ve < 0,001). Sonuç: NLO ile thiol/disülfit homeostasis parametrelerinin karbonmonoksit zehirlenmesi tanısında beraber kullanılması bu hastalarda tanının konulması açısından faydalıdır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA TANRIVERDİ F, YÜZBAŞIOĞLU Y, HAYDAR F, GÖKHAN Ş, ÖZHASENEKLER A, YILDIRIM Ç, KAHRAMAN F, EREN F (2020). EVALUATION OF THIOL DISULPHIDE HOMEOSTASIS AND NEUTROPHILE LYMPHOCYTE RATIO IN CARBON MONOXIDE INTOXICATION. Ankara Medical Journal, 20(1), 47 - 56. 10.5505/amj.2020.71542
Chicago TANRIVERDİ FATİH,YÜZBAŞIOĞLU Yücel,HAYDAR Fadime Güllü ERCAN,GÖKHAN Şervan,ÖZHASENEKLER Ayhan,YILDIRIM Çağdaş,KAHRAMAN Fatih,EREN Funda EVALUATION OF THIOL DISULPHIDE HOMEOSTASIS AND NEUTROPHILE LYMPHOCYTE RATIO IN CARBON MONOXIDE INTOXICATION. Ankara Medical Journal 20, no.1 (2020): 47 - 56. 10.5505/amj.2020.71542
MLA TANRIVERDİ FATİH,YÜZBAŞIOĞLU Yücel,HAYDAR Fadime Güllü ERCAN,GÖKHAN Şervan,ÖZHASENEKLER Ayhan,YILDIRIM Çağdaş,KAHRAMAN Fatih,EREN Funda EVALUATION OF THIOL DISULPHIDE HOMEOSTASIS AND NEUTROPHILE LYMPHOCYTE RATIO IN CARBON MONOXIDE INTOXICATION. Ankara Medical Journal, vol.20, no.1, 2020, ss.47 - 56. 10.5505/amj.2020.71542
AMA TANRIVERDİ F,YÜZBAŞIOĞLU Y,HAYDAR F,GÖKHAN Ş,ÖZHASENEKLER A,YILDIRIM Ç,KAHRAMAN F,EREN F EVALUATION OF THIOL DISULPHIDE HOMEOSTASIS AND NEUTROPHILE LYMPHOCYTE RATIO IN CARBON MONOXIDE INTOXICATION. Ankara Medical Journal. 2020; 20(1): 47 - 56. 10.5505/amj.2020.71542
Vancouver TANRIVERDİ F,YÜZBAŞIOĞLU Y,HAYDAR F,GÖKHAN Ş,ÖZHASENEKLER A,YILDIRIM Ç,KAHRAMAN F,EREN F EVALUATION OF THIOL DISULPHIDE HOMEOSTASIS AND NEUTROPHILE LYMPHOCYTE RATIO IN CARBON MONOXIDE INTOXICATION. Ankara Medical Journal. 2020; 20(1): 47 - 56. 10.5505/amj.2020.71542
IEEE TANRIVERDİ F,YÜZBAŞIOĞLU Y,HAYDAR F,GÖKHAN Ş,ÖZHASENEKLER A,YILDIRIM Ç,KAHRAMAN F,EREN F "EVALUATION OF THIOL DISULPHIDE HOMEOSTASIS AND NEUTROPHILE LYMPHOCYTE RATIO IN CARBON MONOXIDE INTOXICATION." Ankara Medical Journal, 20, ss.47 - 56, 2020. 10.5505/amj.2020.71542