Does antenatal magnesium sulphate improve hearing function in premature newborns?

Ozkan, Hilal; Çakır, Salih Çağrı; Tütüncü Toker, Rabia; Cetinkaya Demir, Bilge; ORHAN, ADNAN; Özerkan, Kemal; Kasapoglu, Fikret; ATALAY, MEHMET ARAL; Kasapoğlu, Işıl

doi:10.4274/jtgga.galenos.2019.2019.0070

Does antenatal magnesium sulphate improve hearing function in premature newborns?

Işıl KASAPOĞLU, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Bursa, Türkiye)

Bilge ÇETİNKAYA DEMİR, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Bursa, Türkiye)

Mehmet Aral ATALAY, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Bursa, Türkiye)

Adnan ORHAN, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Bursa, Türkiye)

Hilal ÖZKAN, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Bursa, Türkiye)

Salih Çağrı ÇAKIR, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Bursa, Türkiye)

Rabia TÜTÜNCÜ TOKER, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Bursa, Türkiye)

Fikret KASAPOĞLU, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Otorinolarengoloji Anabilim Dalı, Bursa, Türkiye)

Kemal ÖZERKAN (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Bursa, Türkiye)

Journal of the Turkish-German Gynecological Association

2 0

Yıl: 2020 Cilt: 21 Sayı: 3 Sayfa Aralığı: 187 - 192 Metin Dili: İngilizce DOI: 10.4274/jtgga.galenos.2019.2019.0070 İndeks Tarihi: 29-11-2020

Does antenatal magnesium sulphate improve hearing function in premature newborns?

Öz:

Objective: To evaluate whether antenatal magnesium sulphate (MgSO4) exposure has a neuroprotective effect against hearing impairment inpremature newborns.Material and Methods: Retrospective cohort study was performed with prematurely (<37 weeks) delivered newborns at a tertiary universityhospital. Newborns of 92 women who received MgSO4 infusions (study group) for various indications were compared to newborns of 147 womenwho did not receive MgSO4 infusions (control group). All eligible premature newborn underwent hearing screening by auditory brainstemresponse (ABR) testing before being discharged from the hospital.Results: The fail rate for ABR hearing screening was 3.3% (n=3) in the study group and 10.9% (n=16) in the control group (p=0.034). The rateof concurrent use of betamethasone was higher in the study group (72.8%; n=67) compared to control group (29.2%; n=43) (p<0.001). Otherneonatal parameters, such as the number of neonates who were small for gestational age and the rate of microcephaly were similar betweenthe groups (p=0.54, p=0.48, respectively). After adjusting for co-variates including the use of betamethasone and gestational age at delivery, nostatistically significant association between antenatal administration of MgSO4 and ABR fail rates were found (p=0.07).Conclusion: These results do not suggest a significant benefit in terms of hearing impairment in premature newborns when antenatal MgSO4infusion was given. (J Turk Ger Gynecol Assoc 2020; 21: 187-92)

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kasapoğlu I, Cetinkaya Demir B, ATALAY M, ORHAN A, Ozkan H, Çakır S, Tütüncü Toker R, Kasapoglu F, Özerkan K (2020). Does antenatal magnesium sulphate improve hearing function in premature newborns?. , 187 - 192. 10.4274/jtgga.galenos.2019.2019.0070
Chicago	Kasapoğlu Işıl,Cetinkaya Demir Bilge,ATALAY MEHMET ARAL,ORHAN ADNAN,Ozkan Hilal,Çakır Salih Çağrı,Tütüncü Toker Rabia,Kasapoglu Fikret,Özerkan Kemal Does antenatal magnesium sulphate improve hearing function in premature newborns?. (2020): 187 - 192. 10.4274/jtgga.galenos.2019.2019.0070
MLA	Kasapoğlu Işıl,Cetinkaya Demir Bilge,ATALAY MEHMET ARAL,ORHAN ADNAN,Ozkan Hilal,Çakır Salih Çağrı,Tütüncü Toker Rabia,Kasapoglu Fikret,Özerkan Kemal Does antenatal magnesium sulphate improve hearing function in premature newborns?. , 2020, ss.187 - 192. 10.4274/jtgga.galenos.2019.2019.0070
AMA	Kasapoğlu I,Cetinkaya Demir B,ATALAY M,ORHAN A,Ozkan H,Çakır S,Tütüncü Toker R,Kasapoglu F,Özerkan K Does antenatal magnesium sulphate improve hearing function in premature newborns?. . 2020; 187 - 192. 10.4274/jtgga.galenos.2019.2019.0070
Vancouver	Kasapoğlu I,Cetinkaya Demir B,ATALAY M,ORHAN A,Ozkan H,Çakır S,Tütüncü Toker R,Kasapoglu F,Özerkan K Does antenatal magnesium sulphate improve hearing function in premature newborns?. . 2020; 187 - 192. 10.4274/jtgga.galenos.2019.2019.0070
IEEE	Kasapoğlu I,Cetinkaya Demir B,ATALAY M,ORHAN A,Ozkan H,Çakır S,Tütüncü Toker R,Kasapoglu F,Özerkan K "Does antenatal magnesium sulphate improve hearing function in premature newborns?." , ss.187 - 192, 2020. 10.4274/jtgga.galenos.2019.2019.0070
ISNAD	Kasapoğlu, Işıl vd. "Does antenatal magnesium sulphate improve hearing function in premature newborns?". (2020), 187-192. https://doi.org/10.4274/jtgga.galenos.2019.2019.0070

APA	Kasapoğlu I, Cetinkaya Demir B, ATALAY M, ORHAN A, Ozkan H, Çakır S, Tütüncü Toker R, Kasapoglu F, Özerkan K (2020). Does antenatal magnesium sulphate improve hearing function in premature newborns?. Journal of the Turkish-German Gynecological Association, 21(3), 187 - 192. 10.4274/jtgga.galenos.2019.2019.0070
Chicago	Kasapoğlu Işıl,Cetinkaya Demir Bilge,ATALAY MEHMET ARAL,ORHAN ADNAN,Ozkan Hilal,Çakır Salih Çağrı,Tütüncü Toker Rabia,Kasapoglu Fikret,Özerkan Kemal Does antenatal magnesium sulphate improve hearing function in premature newborns?. Journal of the Turkish-German Gynecological Association 21, no.3 (2020): 187 - 192. 10.4274/jtgga.galenos.2019.2019.0070
MLA	Kasapoğlu Işıl,Cetinkaya Demir Bilge,ATALAY MEHMET ARAL,ORHAN ADNAN,Ozkan Hilal,Çakır Salih Çağrı,Tütüncü Toker Rabia,Kasapoglu Fikret,Özerkan Kemal Does antenatal magnesium sulphate improve hearing function in premature newborns?. Journal of the Turkish-German Gynecological Association, vol.21, no.3, 2020, ss.187 - 192. 10.4274/jtgga.galenos.2019.2019.0070
AMA	Kasapoğlu I,Cetinkaya Demir B,ATALAY M,ORHAN A,Ozkan H,Çakır S,Tütüncü Toker R,Kasapoglu F,Özerkan K Does antenatal magnesium sulphate improve hearing function in premature newborns?. Journal of the Turkish-German Gynecological Association. 2020; 21(3): 187 - 192. 10.4274/jtgga.galenos.2019.2019.0070
Vancouver	Kasapoğlu I,Cetinkaya Demir B,ATALAY M,ORHAN A,Ozkan H,Çakır S,Tütüncü Toker R,Kasapoglu F,Özerkan K Does antenatal magnesium sulphate improve hearing function in premature newborns?. Journal of the Turkish-German Gynecological Association. 2020; 21(3): 187 - 192. 10.4274/jtgga.galenos.2019.2019.0070
IEEE	Kasapoğlu I,Cetinkaya Demir B,ATALAY M,ORHAN A,Ozkan H,Çakır S,Tütüncü Toker R,Kasapoglu F,Özerkan K "Does antenatal magnesium sulphate improve hearing function in premature newborns?." Journal of the Turkish-German Gynecological Association, 21, ss.187 - 192, 2020. 10.4274/jtgga.galenos.2019.2019.0070
ISNAD	Kasapoğlu, Işıl vd. "Does antenatal magnesium sulphate improve hearing function in premature newborns?". Journal of the Turkish-German Gynecological Association 21/3 (2020), 187-192. https://doi.org/10.4274/jtgga.galenos.2019.2019.0070