TY  - JOUR
TI  - Does antenatal magnesium sulphate improve hearing function in premature newborns?
AB  - Objective: To evaluate whether antenatal magnesium sulphate (MgSO4) exposure has a neuroprotective effect against hearing impairment inpremature newborns.Material and Methods: Retrospective cohort study was performed with prematurely (<37 weeks) delivered newborns at a tertiary universityhospital. Newborns of 92 women who received MgSO4 infusions (study group) for various indications were compared to newborns of 147 womenwho did not receive MgSO4 infusions (control group). All eligible premature newborn underwent hearing screening by auditory brainstemresponse (ABR) testing before being discharged from the hospital.Results: The fail rate for ABR hearing screening was 3.3% (n=3) in the study group and 10.9% (n=16) in the control group (p=0.034). The rateof concurrent use of betamethasone was higher in the study group (72.8%; n=67) compared to control group (29.2%; n=43) (p<0.001). Otherneonatal parameters, such as the number of neonates who were small for gestational age and the rate of microcephaly were similar betweenthe groups (p=0.54, p=0.48, respectively). After adjusting for co-variates including the use of betamethasone and gestational age at delivery, nostatistically significant association between antenatal administration of MgSO4 and ABR fail rates were found (p=0.07).Conclusion: These results do not suggest a significant benefit in terms of hearing impairment in premature newborns when antenatal MgSO4infusion was given. (J Turk Ger Gynecol Assoc 2020; 21: 187-92)
AU  - Ozkan, Hilal
AU  - Çakır, Salih Çağrı
AU  - Tütüncü Toker, Rabia
AU  - Cetinkaya Demir, Bilge
AU  - ORHAN, ADNAN
AU  - Özerkan, Kemal
AU  - Kasapoglu, Fikret
AU  - ATALAY, MEHMET ARAL
AU  - Kasapoğlu, Işıl
DO  - 10.4274/jtgga.galenos.2019.2019.0070
PY  - 2020
JO  - Journal of the Turkish-German Gynecological Association
VL  - 21
IS  - 3
SN  - 1309-0399
SP  - 187
EP  - 192
DB  - TRDizin
UR  - http://search/yayin/detay/381452
ER  -