Yıl: 2018 Cilt: 22 Sayı: 4 Sayfa Aralığı: 578 - 586 Metin Dili: İngilizce DOI: 10.12991/jrp.2018.100 İndeks Tarihi: 03-12-2020

Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet

Öz:
The oral application of drugs is the most popular route for achieving systemic effects, nevertheless, it islimited by difficulties related to physicochemical properties of the drug. Solid lipid nanoparticles (SLNs) are appealingextensive notice because of showing increased solubility and improved oral bioavailability via different mechanisms.The aim of the study is to compare and peruse the in-situ permeation of nebivolol (NBV) loaded SLN and its commercialtablet formulation used for the treatment of hypertension. For this aim Single-Pass Intestinal Perfusion (SPIP) methodwas used for in-situ permeation studies. NBV loaded SLNs were prepared and modified with polyethylene glycol (PEG).In order to prepare SLNs by homogenization technique, compritol, lecithin and poloxamer were chosen. Particle sizes ofblank and loaded SLN were 213.4±17.5 and 264.1±18.8 nm, respectively with polydispersity index values ofapproximately 0.3 for each. NBV loading resulted in positive electrical charge on SLNs. The encapsulation efficiency was98.04±0.2 %. Permeability coefficient values were tripled when NBV was incorporated in SLNs and doubled when pureNBV was given separately with a blank SLN. PEG modified SLN can be used to enhance oral absorption of NBV, andSLNs alone can be used as permeation enhancer in oral drug delivery..
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Gokce E, KAYNAK M, Yurdasiper A, ÜSTÜNDAĞ-OKUR N (2018). Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet. , 578 - 586. 10.12991/jrp.2018.100
Chicago Gokce Evren Homan,KAYNAK Mustafa Sinan,Yurdasiper Aysu,ÜSTÜNDAĞ-OKUR Neslihan Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet. (2018): 578 - 586. 10.12991/jrp.2018.100
MLA Gokce Evren Homan,KAYNAK Mustafa Sinan,Yurdasiper Aysu,ÜSTÜNDAĞ-OKUR Neslihan Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet. , 2018, ss.578 - 586. 10.12991/jrp.2018.100
AMA Gokce E,KAYNAK M,Yurdasiper A,ÜSTÜNDAĞ-OKUR N Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet. . 2018; 578 - 586. 10.12991/jrp.2018.100
Vancouver Gokce E,KAYNAK M,Yurdasiper A,ÜSTÜNDAĞ-OKUR N Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet. . 2018; 578 - 586. 10.12991/jrp.2018.100
IEEE Gokce E,KAYNAK M,Yurdasiper A,ÜSTÜNDAĞ-OKUR N "Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet." , ss.578 - 586, 2018. 10.12991/jrp.2018.100
ISNAD Gokce, Evren Homan vd. "Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet". (2018), 578-586. https://doi.org/10.12991/jrp.2018.100
APA Gokce E, KAYNAK M, Yurdasiper A, ÜSTÜNDAĞ-OKUR N (2018). Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet. Marmara Pharmaceutical Journal, 22(4), 578 - 586. 10.12991/jrp.2018.100
Chicago Gokce Evren Homan,KAYNAK Mustafa Sinan,Yurdasiper Aysu,ÜSTÜNDAĞ-OKUR Neslihan Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet. Marmara Pharmaceutical Journal 22, no.4 (2018): 578 - 586. 10.12991/jrp.2018.100
MLA Gokce Evren Homan,KAYNAK Mustafa Sinan,Yurdasiper Aysu,ÜSTÜNDAĞ-OKUR Neslihan Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet. Marmara Pharmaceutical Journal, vol.22, no.4, 2018, ss.578 - 586. 10.12991/jrp.2018.100
AMA Gokce E,KAYNAK M,Yurdasiper A,ÜSTÜNDAĞ-OKUR N Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet. Marmara Pharmaceutical Journal. 2018; 22(4): 578 - 586. 10.12991/jrp.2018.100
Vancouver Gokce E,KAYNAK M,Yurdasiper A,ÜSTÜNDAĞ-OKUR N Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet. Marmara Pharmaceutical Journal. 2018; 22(4): 578 - 586. 10.12991/jrp.2018.100
IEEE Gokce E,KAYNAK M,Yurdasiper A,ÜSTÜNDAĞ-OKUR N "Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet." Marmara Pharmaceutical Journal, 22, ss.578 - 586, 2018. 10.12991/jrp.2018.100
ISNAD Gokce, Evren Homan vd. "Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet". Marmara Pharmaceutical Journal 22/4 (2018), 578-586. https://doi.org/10.12991/jrp.2018.100