TY  - JOUR
TI  - Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet
AB  - The oral application of drugs is the most popular route for achieving systemic effects, nevertheless, it islimited by difficulties related to physicochemical properties of the drug. Solid lipid nanoparticles (SLNs) are appealingextensive notice because of showing increased solubility and improved oral bioavailability via different mechanisms.The aim of the study is to compare and peruse the in-situ permeation of nebivolol (NBV) loaded SLN and its commercialtablet formulation used for the treatment of hypertension. For this aim Single-Pass Intestinal Perfusion (SPIP) methodwas used for in-situ permeation studies. NBV loaded SLNs were prepared and modified with polyethylene glycol (PEG).In order to prepare SLNs by homogenization technique, compritol, lecithin and poloxamer were chosen. Particle sizes ofblank and loaded SLN were 213.4±17.5 and 264.1±18.8 nm, respectively with polydispersity index values ofapproximately 0.3 for each. NBV loading resulted in positive electrical charge on SLNs. The encapsulation efficiency was98.04±0.2 %. Permeability coefficient values were tripled when NBV was incorporated in SLNs and doubled when pureNBV was given separately with a blank SLN. PEG modified SLN can be used to enhance oral absorption of NBV, andSLNs alone can be used as permeation enhancer in oral drug delivery..
AU  - KAYNAK, Mustafa Sinan
AU  - Yurdasiper, Aysu
AU  - Gokce, Evren Homan
AU  - ÜSTÜNDAĞ-OKUR, Neslihan
DO  - 10.12991/jrp.2018.100
PY  - 2018
JO  - Marmara Pharmaceutical Journal
VL  - 22
IS  - 4
SN  - 1309-0801
SP  - 578
EP  - 586
DB  - TRDizin
UR  - http://search/yayin/detay/382806
ER  -