TY  - JOUR
TI  - Unclear Issues Regarding COVID-19
AB  - Scientists from all over the world have been intensively working to discover different aspects of Coronavirus disease 2019 (COVID-19) since the first cluster of cases was reported in China. Herein, we aimed to investigate unclear issues related to transmission and pathogenesis of disease as well as accuracy of diagnostic tests and treatment modalities. A literature search on PubMed, Ovid, and EMBASE databases was conducted, and articles pertinent to identified search terms were extracted. A snow-ball search strategy was followed in order to retrieve additional relevant articles. It was reported that viral spread may occur during the asymptomatic phase of infection, and viral load was suggested to be a useful marker to assess disease severity. In contrast to immune response against viral infections, cytotoxic T lymphocytes decline in SARS-CoV-2 infection, which can be partially explained by direct invasion of T lymphocytes or apoptosis activated by SARS-CoV-2. Dysregulation of the urokinase pathway, cleavage of the SARS-CoV-2 Spike protein by FXa and FIIa, and consumption coagulopathy were the proposed mechanisms of the coagulation dysfunction in COVID-19. False-negative rates of reverse transcriptase polymerase chain reaction varied between 3% and 41% across studies. The probability of the positive test was proposed to decrease with the number of days past from symptom onset. Safety issues related to infection spread limit the use of high flow nasal oxygen (HFNO) and continuous positive airway pressure (CPAP) in hypoxic patients. Further studies are required to elucidate the challenging issues, thus enhancing the management of COVID-19 patients.
AU  - Özakıncı, Hilal
AU  - Akgün, Metin
AU  - Esendagli, Dorina
AU  - Yildiz Gulhan, Pinar
AU  - Erçelik, Merve
AU  - Sismanlar Eyuboglu, Tugba
AU  - Ramasli Gursoy, Tugba
AU  - Emiralioglu, Nagehan
AU  - Sertçelik, Ümran
AU  - Karakaş, Fatma Gülsüm
AU  - Asena, Aydin
AU  - Serifoglu, Irem
AU  - marım, feride
AU  - Gurz, Selcuk
AU  - OZCELIK, Neslihan
AU  - Günaydın, Fatma Esra
AU  - Tokgoz Akyil, Fatma
AU  - ÇELİK, selma
AU  - Alkan, Asli
AU  - Er, Berrin
AU  - Karadoğan, Dilek
AU  - Fırıncıoğluları, Ali
AU  - Develi, Elif
AU  - Arikan, Huseyin
AU  - Irmak, Ilim
AU  - Elverisli, Mehmet Fatih
AU  - YILDIZ, Ethem
AU  - YÜKSEL, AYCAN
AU  - Yılmaz Kara, Bilge
AU  - Gunduz Gurkan, Canan
AU  - TOREYIN, NUR
AU  - köse, neslihan
DO  - 10.5152/eurasianjmed.2020.20092
PY  - 2020
JO  - Eurasian Journal of Medicine
VL  - 52
IS  - 2
SN  - 1308-8734
SP  - 191
EP  - 196
DB  - TRDizin
UR  - http://search/yayin/detay/382878
ER  -