TY  - JOUR
TI  - New indicator of cellular ischemia in coronary slow-flow phenomenon: Cell-free DNA
AB  - Objective: Coronary slow-flow phenomenon (CSFP) is defined as the delayed arrival of coronary blood flow to thedistal vascular bed in at least 1 major epicardial coronaryartery. Cell-free DNA (cfDNA) is a type of DNA that circulates freely in the blood once released from nucleated cells.The aim of this study was to determine if the level of cfDNA,which is an indicator of ischemia at the cellular level, wasincreased in CSFP.Methods: The study included 46 patients in total: 23 patients with CSFP and 23 with a normal coronary angiogram(NCA). The level of cfDNA, and clinical, biochemical, andangiographic features of the groups were compared.Results: The mean age was 53.8±10.3 years for the CSFPpatient group and 56.6±9.4 years for the NCA patient group.There was no statistically significant difference between thegroups in terms of basal clinical characteristics or laboratory data. The plasma cfDNA level was 5.04±2.37 ng/µL inthe CSFP patients and 2.28±1.09 ng/µL in the NCA group(p<0.001).Conclusion: Several invasive and noninvasive studies conducted on patients with CSFP have revealed myocardialischemia. The results of this study demonstrated that thelevel of cfDNA was significantly increased in patients withCSFP as a result of ischemia at the cellular level caused bymicrovascular disruption.
AU  - GÜRBÜZEL, MEHMET
AU  - kurtoglu, nuri
AU  - hancer, veysel sabri
AU  - Dogan, Ali
AU  - yolcu, mustafa
DO  - 10.5543/tkda.2020.45605
PY  - 2020
JO  - Türk Kardiyoloji Derneği Arşivi
VL  - 48
IS  - 6
SN  - 1016-5169
SP  - 558
EP  - 565
DB  - TRDizin
UR  - http://search/yayin/detay/383292
ER  -