TY  - JOUR
TI  - Prognostic significance of poorly differentiated cluster grading system in intestinal type gastric adenocarcinoma
AB  - Aim: Gastric carcinoma is the fourth most common carcinoma worldwide. The relationships established between the tumormorphology and the prognosis have not been very effective until recent times. Poorly Differentiated Clusters (PDCs); are structuresthose can be easily identified in H&E sections. A new grading system based on PDC count has been studied in colorectal carcinoma;and found to be associated with prognosis. We have aimed to investigate this concept in gastric carcinoma.Material and Methods: Our study included 80 cases, consisting of 16 females and 64 males having gastric carcinoma with intestinalmorphology. For each case; conventional grade, PDC grade and prognostic parameters to be applied in the study were determined,and statistically compared.Results: Significant discrepancy was found between the two grading systems. PDC tumor grades were statistically related to; medianmetastatic lymph node counts, metastatic lymph node ratios, lymph node stages (pN) and the presence of perineural invasion.Conclusion: In stomach carcinoma; PDC grading system was found to be related to a significant part of the expected parametersand may have a prognostic value.
AU  - Sahin, Nurhan
AU  - ARSLAN, Ahmet Kadir
AU  - AKPOLAT, NUSRET
AU  - Samdanci, Emine
AU  - GÜRÜNLÜOĞLU, SEMRA
AU  - GOKÇE, HASAN
DO  - 10.5455/annalsmedres.2020.06.578
PY  - 2020
JO  - Annals of Medical Research
VL  - 27
IS  - 8
SN  - 2636-7688
SP  - 2022
EP  - 2030
DB  - TRDizin
UR  - http://search/yayin/detay/383348
ER  -