Yıl: 2020 Cilt: 27 Sayı: 8 Sayfa Aralığı: 2067 - 2071 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2020.04.413 İndeks Tarihi: 06-12-2020

Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3

Öz:
Aim: Few studies have evaluated real-world clinical experience with sofosbuvir (SOF) plus ribavirin (RBV) in hepatitis C virus (HCV)genotypes 2 and 3 infections from Turkey. Thus, this study aimed to investigate the results of sofosbuvir plus ribavirin therapy ingenotype 2 and 3 cases followed in an infectious disease clinic at a university hospital in Hatay, southern Turkey.Material and Methods: In this single-centre, retrospective, observational study, 58 eligible patients treated with SOF/RBV (400 mgof SOF plus weight-based RBV) therapy between October 2016 and February 2019 were examined. Forty-three patients who hadcompleted the duration of treatment and had known virological response status were evaluated for treatment outcomes.Results: SOF/RBV achieves a sustained virological response (SVR) rate of 96.3% and 100% in the HCV genotype 2 and 3 groups,respectively, with treatment duration of 12-24 weeks. No patient experienced a virologic breakthrough while only one experiencedvirologic relapse after the completion of therapy. The incidence of adverse events was 25.5% (11/43) while the most common(11.6%) adverse event was ribavirin-related hemolytic anemia.Conclusion: The current study revealed that the SOF/RBV therapy achieved excellent response rates with a good safety profile innon-cirrhotic Turkish patients infected with HCV genotype 2 or 3.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Bal T, çabalak m (2020). Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3. , 2067 - 2071. 10.5455/annalsmedres.2020.04.413
Chicago Bal Tayibe,çabalak mehmet Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3. (2020): 2067 - 2071. 10.5455/annalsmedres.2020.04.413
MLA Bal Tayibe,çabalak mehmet Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3. , 2020, ss.2067 - 2071. 10.5455/annalsmedres.2020.04.413
AMA Bal T,çabalak m Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3. . 2020; 2067 - 2071. 10.5455/annalsmedres.2020.04.413
Vancouver Bal T,çabalak m Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3. . 2020; 2067 - 2071. 10.5455/annalsmedres.2020.04.413
IEEE Bal T,çabalak m "Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3." , ss.2067 - 2071, 2020. 10.5455/annalsmedres.2020.04.413
ISNAD Bal, Tayibe - çabalak, mehmet. "Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3". (2020), 2067-2071. https://doi.org/10.5455/annalsmedres.2020.04.413
APA Bal T, çabalak m (2020). Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3. Annals of Medical Research, 27(8), 2067 - 2071. 10.5455/annalsmedres.2020.04.413
Chicago Bal Tayibe,çabalak mehmet Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3. Annals of Medical Research 27, no.8 (2020): 2067 - 2071. 10.5455/annalsmedres.2020.04.413
MLA Bal Tayibe,çabalak mehmet Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3. Annals of Medical Research, vol.27, no.8, 2020, ss.2067 - 2071. 10.5455/annalsmedres.2020.04.413
AMA Bal T,çabalak m Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3. Annals of Medical Research. 2020; 27(8): 2067 - 2071. 10.5455/annalsmedres.2020.04.413
Vancouver Bal T,çabalak m Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3. Annals of Medical Research. 2020; 27(8): 2067 - 2071. 10.5455/annalsmedres.2020.04.413
IEEE Bal T,çabalak m "Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3." Annals of Medical Research, 27, ss.2067 - 2071, 2020. 10.5455/annalsmedres.2020.04.413
ISNAD Bal, Tayibe - çabalak, mehmet. "Sofosbuvir and Ribavirin in Turkish non-cirrhotic chronic hepatitis C patients infected with genotype 2 or 3". Annals of Medical Research 27/8 (2020), 2067-2071. https://doi.org/10.5455/annalsmedres.2020.04.413