Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice
Yıl: 2020 Cilt: 3 Sayı: 3 Sayfa Aralığı: 149 - 156 Metin Dili: İngilizce DOI: 10.30714/j-ebr.2020361050 İndeks Tarihi: 08-12-2020
Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice
Öz: Aim: To investigate whether different periods of rapid eye movement sleep deprivation (REM SD)contribute to seizure susceptibility, hippocampal oxidative status and balance of inhibition-excitationin the acute epilepsy model.Methods: REM SD was performed using the modified multiple platforms method on adult maleBALB/c mice. Pentylentetrazol (PTZ) was injected to induce seizures and hippocampal totalantioxidant status (TAS), total oxidant status (TOS), gamma aminobutyric acid (GABA), andglutamate levels were measured using the ELISA method.Results: PTZ-induced seizures following 8 h and 72 h REM SD significantly reduced thehippocampal TAS levels, but did not affect the TOS levels. In REM SD groups, especially after 8hours of REM sleep loss, there was a significant increase in glutamate in PTZ induction. Thehippocampal GABA levels were increased by PTZ-induced seizures after 72 h REM SD. PTZinduction after 8 hours of RAM SD leads to a significant increase in the seizure duration.Conclusion: It can be speculated that the REM SD can contribute to seizure susceptibility bychanging the oxidant-antioxidant balance and excitatory and inhibitory tone in the hippocampus.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- [1]Perucca E, French J, Bialer M. Development of new antiepileptic drugs: challenges, incentives, and recent advances. Lancet Neurol. 2007; 6(9):793-804.
- [2]Cetinkaya A, Demir S, Orallar H et al. The effects of treadmill exercise on oxidative stress in Mongolian gerbils with penicillininduced epilepsy. Exp Biomed Res. 2018; 1(1):10-16.
- [3]Hanci F, Canpolat M, Per H et al. The relation between antiepileptic drug type and cognitive functions in childhood epilepsy: A prospective observational study. Exp Biomed Res. 2019; 2(2):62-68.
- [4]Pitkanen, A, Sutula TP. Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol. 2002; 1(3):173-81.
- [5]Baulac M, Pitkanen A. Research priorities in epilepsy for the next decade—A representative view of the European scientific community: Summary of the ILAE Epilepsy Research Workshop, Brussels, 17– 18 January 2008. Epilepsia. 2009; 50(3):571-83.
- [6]Abbott SM, Videnovic A. Chronic sleep disturbance and neural injury: links to neurodegenerative disease. Nat Sci Sleep. 2016:25; 8:55-61.
- [7]Scalise A, Desiato MT, Gigli GL, et al. Increasing cortical excitability: a possible explanation for the proconvulsant role of sleep deprivation. Sleep. 2006; 29(12):1595- 98.
- [8]Ng M, Pavlova M. Why are seizures rare in rapid eye movement sleep? Review of the frequency of seizures in different sleep stages. Epilepsy Res Treat. 2013;2013:932790.
- [9]Soto-Rodriguez S, Lopez-Armas G, Luquin S, et al. Rapid Eye Movement Sleep Deprivation Produces Long-Term Detrimental Effects in Spatial Memory and Modifies the Cellular Composition of the Subgranular Zone. Front Cell Neurosci. 2016; 10(132):1-13.
- [10]Machado RB, Hipólide DC, Benedito-Silva AA, Tufik S. Sleep deprivation induced by the modified multiple platform technique: quantification of sleep loss and recovery. Brain Res. 2004; 1004(1-2):45-51.
- [11]Tufek A, Tokgoz O, Aliosmanoglu I, et al. The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats. Int J Surg. 2013; 11(1):96-100.
- [12]Jain S, Webster TJ, Sharma A, et al. Intracellular reactive oxidative stress, cell proliferation and apoptosis of Schwann cells on carbon nanofibrous substrates. Biomaterials. 2013; 34(21):4891-901.
- [13]Reimund E. The free-radical flux theory of sleep. Med Hypotheses. 1994; 43(4):231-33.
- [14]Rauca C, Zerbe R, Jantze H. Formation of free hydroxyl radicals after pentylenetetrazol-induced seizure and kindling. Brain Res. 1999;847(2):347‐51.
- [15]Ramanathan L, Gulyani S, Nienhuis R, et al. Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem. Neuroreport. 2002; 13(11):1387- 90.
- [16]Süer C, Dolu N, Artis AS, et al. The effects of long-term sleep deprivation on the long-term potentiation in the dentate gyrus and brain oxidation status in rats. Neurosci Res. 2011; 70(1):71-77.
- [17]Cortese BM, Mitchell TR, Galloway MP, et al. Region-specific alteration in brain glutamate: possible relationship to risk taking behavior. Physiol Behav. 2010; 99(4):445-50.
| APA | AKKAYA R, KARABULUT S, Taskiran A (2020). Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice. , 149 - 156. 10.30714/j-ebr.2020361050 |
| Chicago | AKKAYA Recep,KARABULUT SEBAHATTIN,Taskiran Ahmet Sevki Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice. (2020): 149 - 156. 10.30714/j-ebr.2020361050 |
| MLA | AKKAYA Recep,KARABULUT SEBAHATTIN,Taskiran Ahmet Sevki Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice. , 2020, ss.149 - 156. 10.30714/j-ebr.2020361050 |
| AMA | AKKAYA R,KARABULUT S,Taskiran A Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice. . 2020; 149 - 156. 10.30714/j-ebr.2020361050 |
| Vancouver | AKKAYA R,KARABULUT S,Taskiran A Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice. . 2020; 149 - 156. 10.30714/j-ebr.2020361050 |
| IEEE | AKKAYA R,KARABULUT S,Taskiran A "Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice." , ss.149 - 156, 2020. 10.30714/j-ebr.2020361050 |
| ISNAD | AKKAYA, Recep vd. "Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice". (2020), 149-156. https://doi.org/10.30714/j-ebr.2020361050 |
| APA | AKKAYA R, KARABULUT S, Taskiran A (2020). Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice. Experimental Biomedical Research, 3(3), 149 - 156. 10.30714/j-ebr.2020361050 |
| Chicago | AKKAYA Recep,KARABULUT SEBAHATTIN,Taskiran Ahmet Sevki Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice. Experimental Biomedical Research 3, no.3 (2020): 149 - 156. 10.30714/j-ebr.2020361050 |
| MLA | AKKAYA Recep,KARABULUT SEBAHATTIN,Taskiran Ahmet Sevki Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice. Experimental Biomedical Research, vol.3, no.3, 2020, ss.149 - 156. 10.30714/j-ebr.2020361050 |
| AMA | AKKAYA R,KARABULUT S,Taskiran A Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice. Experimental Biomedical Research. 2020; 3(3): 149 - 156. 10.30714/j-ebr.2020361050 |
| Vancouver | AKKAYA R,KARABULUT S,Taskiran A Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice. Experimental Biomedical Research. 2020; 3(3): 149 - 156. 10.30714/j-ebr.2020361050 |
| IEEE | AKKAYA R,KARABULUT S,Taskiran A "Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice." Experimental Biomedical Research, 3, ss.149 - 156, 2020. 10.30714/j-ebr.2020361050 |
| ISNAD | AKKAYA, Recep vd. "Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice". Experimental Biomedical Research 3/3 (2020), 149-156. https://doi.org/10.30714/j-ebr.2020361050 |
