Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation

LİN, Haoyu; Lİ, Xiandong; LV, Xi; WANG, Yaping; ZHANG, Xunnan; PENG, Chunyan; ZHANG, Jicai

Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation

Xunnan ZHANG, (Hubei University of MedicinePostgraduate Training Basement of Jinzhou Medicical University,Taihe Hospital,Hubei,P.R. China)

Xi LV, (Hubei University of Medicine,Postgraduate Training Basement of Jinzhou Medicical University,Taihe Hospital,Hubei,P.R. China)

Yaping WANG, (Hubei University of Medicine,Postgraduate Training Basement of Jinzhou Medicical University,Taihe Hospital,Hubei,P.R. China)

Jicai ZHANG, (Hubei University of Medicine,Postgraduate Training Basement of Jinzhou Medicical University,Taihe Hospital,Hubei,P.R. China)

Xiandong Lİ, (Hubei University of Medicine,Taihe Hospital, Department of Laboratory Medicine, Hubei,P.R. China)

Chunyan PENG, (Hubei University of Medicine,Taihe Hospital, Department of Laboratory Medicine, Hubei,P.R. China)

Haoyu LİN (The First Affiliated Hospital of Shantou University Medical College,Department of Breast and Thyroid Surgery, Guangdong,P.R. China)

The Anatolian Journal of Cardiology

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Yıl: 2020 Cilt: 24 Sayı: 3 Sayfa Aralığı: 160 - 174 Metin Dili: İngilizce İndeks Tarihi: 10-12-2020

Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation

Öz:

Objective: To extensively use blood transcriptome analysis to identify potential diagnostic and therapeutic targets for cardiovascular diseases.Methods: Two gene expression datasets (GSE59867 and GSE62646) were downloaded from GEO DataSets to identify altered blood transcriptomes in patients with ST-segment elevation myocardial infarction (STEMI) compared to stable coronary artery disease (CAD). Thereafter, several computa-tional approaches were taken to determine functional roles and regulatory networks of differentially expressed genes (DEGs). Finally, the expression of dysregulated two hub genes–suppressor of cytokine signaling 3 (SOCS3) and haptoglobin (HP)–were validated in a case–control study.Results: A total of 119 DEGs were identified in the discovery phase, consisting of 71 downregulated genes and 48 upregulated genes; two hub modules consisting of two hub genes–SOCS3 and HP–were identified. In the validation phase, both SOCS3 and HP were significantly downregu-lated in the stable CAD and acute coronary syndrome (ACS) patients when compared with healthy controls. Meanwhile, HP was significantly upregulated in STEMI patients when compared with stable CAD patients (p=0.041). Logistic regression analysis indicated that: downregulated expression of HP correlated with increased risk of CAD [odds ratio (OR)=0.52, 95% confidence interval (CI)=0.31~0.87, p=0.013]; and downregulat-ed expression of SOCS3 correlated with increased risk of ACS (OR=0.66, 95% CI=0.46~0.94, p=0.023) when age, gender, history of hyperlipidemia, diabetes and hypertension were included as covariates.Conclusion: Future clarification of how SOCS3 and HP influence the pathogenesis of disease may pave the way for the development of novel diagnostic and therapeutic methods. (Anatol J Cardiol 2020; 24: 160-74)

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APA	ZHANG X, LV X, WANG Y, ZHANG J, Lİ X, PENG C, LİN H (2020). Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation. , 160 - 174.
Chicago	ZHANG Xunnan,LV Xi,WANG Yaping,ZHANG Jicai,Lİ Xiandong,PENG Chunyan,LİN Haoyu Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation. (2020): 160 - 174.
MLA	ZHANG Xunnan,LV Xi,WANG Yaping,ZHANG Jicai,Lİ Xiandong,PENG Chunyan,LİN Haoyu Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation. , 2020, ss.160 - 174.
AMA	ZHANG X,LV X,WANG Y,ZHANG J,Lİ X,PENG C,LİN H Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation. . 2020; 160 - 174.
Vancouver	ZHANG X,LV X,WANG Y,ZHANG J,Lİ X,PENG C,LİN H Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation. . 2020; 160 - 174.
IEEE	ZHANG X,LV X,WANG Y,ZHANG J,Lİ X,PENG C,LİN H "Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation." , ss.160 - 174, 2020.
ISNAD	ZHANG, Xunnan vd. "Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation". (2020), 160-174.

APA	ZHANG X, LV X, WANG Y, ZHANG J, Lİ X, PENG C, LİN H (2020). Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation. The Anatolian Journal of Cardiology, 24(3), 160 - 174.
Chicago	ZHANG Xunnan,LV Xi,WANG Yaping,ZHANG Jicai,Lİ Xiandong,PENG Chunyan,LİN Haoyu Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation. The Anatolian Journal of Cardiology 24, no.3 (2020): 160 - 174.
MLA	ZHANG Xunnan,LV Xi,WANG Yaping,ZHANG Jicai,Lİ Xiandong,PENG Chunyan,LİN Haoyu Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation. The Anatolian Journal of Cardiology, vol.24, no.3, 2020, ss.160 - 174.
AMA	ZHANG X,LV X,WANG Y,ZHANG J,Lİ X,PENG C,LİN H Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation. The Anatolian Journal of Cardiology. 2020; 24(3): 160 - 174.
Vancouver	ZHANG X,LV X,WANG Y,ZHANG J,Lİ X,PENG C,LİN H Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation. The Anatolian Journal of Cardiology. 2020; 24(3): 160 - 174.
IEEE	ZHANG X,LV X,WANG Y,ZHANG J,Lİ X,PENG C,LİN H "Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation." The Anatolian Journal of Cardiology, 24, ss.160 - 174, 2020.
ISNAD	ZHANG, Xunnan vd. "Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation". The Anatolian Journal of Cardiology 24/3 (2020), 160-174.