Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats
Yıl: 2020 Cilt: 45 Sayı: 1 Sayfa Aralığı: 251 - 256 Metin Dili: İngilizce DOI: 10.17826/cumj.648050 İndeks Tarihi: 10-12-2020
Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats
Öz: Purpose: We investigated the effects of Quercetin andCoenzyme Q10 antioxidant, on gentamicin-induced renalfailure in rats.Materials and Methods: The rats were given gentamicin(100 mg/kg/day, i.m., once a day), gentamicin (100mg/kg/day, i.m.once a day) + Quercetin (15 mg/kg i.p.once a day) and gentamicin (100 mg/kg/day, i.m.) +Coenzyme Q10 (8 mg/kg i.m. once a day).Results: In control the BUN value was 26.8 ± 0.8(mg/100 mL); whereas, it was 117.3 ± 15.4 in gentamicingroup. Renal histopathologic examination confirmed acutetubular necrosis in this group. In rats treated withgentamicin + Quercetin and gentamicin + Coenzyme Q10,a partial improvement in biochemical and histologicparameters was observed. BUN values were 117.3 ± 15.4,44.0 ± 8.3, 47.8 ± 13.8 in gentamicin, gentamicin plusQuercetin and gentamicin plus Coenzyme Q10 treatedgroups, respectively. Creatinine values were 4.3 ± 0.6, 0.8± 0.1, 1.5 ± 0.4 in gentamicin, gentamicin plus Quercetinand gentamicin plus Coenzyme Q10 treated groups,respectively.Conclusion: These results suggest that the administrationof Quercetin and Coenzyme Q10 may have a protectiveeffect on gentamicin-induced nephrotoxicity in rats.
Anahtar Kelime: Quercetin ve Koenzim Q10'un sıçanlarda gentamisin kaynaklı nefrotoksisite üzerine etkileri
Öz: Amaç: Gentamisinle böbrek yetmezliği oluşturulan sıçanlarda Quercetin ve CoQ10 nun antioksidan etkilerini araştırmak amaçlanmıştır. Gereç ve Yöntem: Sıçanlara gentamicin (100 mg/kg/day, i.m., günde 1 kez), gentamicin (100 mg/kg/day, i.m.) + Quercetin (15 mg/kg i.p. günde 1 kez) and gentamicin (100 mg/kg/day, i.m.) + CoQ10 (8 mg/kg i.m. günde 1 kez) uygulandı. Bulgular: Kontrol grubundaki BUN değeri 26.8 ± 0.8 (mg/100 mL); buna karşın gentamisin grubunda 117.3 ± 15.4 bulunmuştur. Böbrek histopatolojik inceleme, bu grupta akut tübüler nekrozu doğruladı. Gentamicin + Quercetin ve gentamicin + CoQ10 uygulanan sıçanlarda biyokimyasal ve histolojik parametrelerde kısmi iyileşme gözlemlenmiştir. BUN değerleri gentamisin, gentamisin + Quercetin and gentamisin + CoQ10 gruplarında sırasıyla 117.3 ± 15.4, 44.0 ± 8.3, 47.8 ± 13.8 bulunmuştur. Gentamisin ile aralarında anlamlı farklılık bulunmuştur. Kreatinin değerleri gentamisin, gentamisin + Quercetin ve gentamisin + Koenzim Q10 ile tedavi edilen gruplarda sırasıyla 4.3 ± 0.6, 0.8 ± 0.1, 1.5 ± 0.4 idi. Sonuç: Bu sonuçlar Quercetin ve CoQ10 uygulanmasının gentamisinle nefrotoksisite oluşturulan sıçanlarda koruyucu etkisi olduğunu göstermiştir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | PINAR N, KARATAŞ Y, Gonlusen G, DAĞLIOĞLU Y (2020). Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. , 251 - 256. 10.17826/cumj.648050 |
| Chicago | PINAR Neslihan,KARATAŞ Yusuf,Gonlusen Gulfiliz,DAĞLIOĞLU Yusuf Kenan Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. (2020): 251 - 256. 10.17826/cumj.648050 |
| MLA | PINAR Neslihan,KARATAŞ Yusuf,Gonlusen Gulfiliz,DAĞLIOĞLU Yusuf Kenan Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. , 2020, ss.251 - 256. 10.17826/cumj.648050 |
| AMA | PINAR N,KARATAŞ Y,Gonlusen G,DAĞLIOĞLU Y Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. . 2020; 251 - 256. 10.17826/cumj.648050 |
| Vancouver | PINAR N,KARATAŞ Y,Gonlusen G,DAĞLIOĞLU Y Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. . 2020; 251 - 256. 10.17826/cumj.648050 |
| IEEE | PINAR N,KARATAŞ Y,Gonlusen G,DAĞLIOĞLU Y "Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats." , ss.251 - 256, 2020. 10.17826/cumj.648050 |
| ISNAD | PINAR, Neslihan vd. "Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats". (2020), 251-256. https://doi.org/10.17826/cumj.648050 |
| APA | PINAR N, KARATAŞ Y, Gonlusen G, DAĞLIOĞLU Y (2020). Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. Cukurova Medical Journal, 45(1), 251 - 256. 10.17826/cumj.648050 |
| Chicago | PINAR Neslihan,KARATAŞ Yusuf,Gonlusen Gulfiliz,DAĞLIOĞLU Yusuf Kenan Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. Cukurova Medical Journal 45, no.1 (2020): 251 - 256. 10.17826/cumj.648050 |
| MLA | PINAR Neslihan,KARATAŞ Yusuf,Gonlusen Gulfiliz,DAĞLIOĞLU Yusuf Kenan Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. Cukurova Medical Journal, vol.45, no.1, 2020, ss.251 - 256. 10.17826/cumj.648050 |
| AMA | PINAR N,KARATAŞ Y,Gonlusen G,DAĞLIOĞLU Y Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. Cukurova Medical Journal. 2020; 45(1): 251 - 256. 10.17826/cumj.648050 |
| Vancouver | PINAR N,KARATAŞ Y,Gonlusen G,DAĞLIOĞLU Y Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. Cukurova Medical Journal. 2020; 45(1): 251 - 256. 10.17826/cumj.648050 |
| IEEE | PINAR N,KARATAŞ Y,Gonlusen G,DAĞLIOĞLU Y "Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats." Cukurova Medical Journal, 45, ss.251 - 256, 2020. 10.17826/cumj.648050 |
| ISNAD | PINAR, Neslihan vd. "Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats". Cukurova Medical Journal 45/1 (2020), 251-256. https://doi.org/10.17826/cumj.648050 |
