TY  - JOUR
TI  - Association of Pericentric Inv(12)(p11.2q14) with Infertility and Recurrent Miscarriages: Case Report and Literature Review
AB  - Infertility, reported in 15% of the couples who want to have children, is an importantworldwide health problem. Recurrent miscarriage, observed in 15–25% of pregnancies, isanother important health issue affecting millions of couples in the world. Despite many geneticfactors have been associated with infertility or recurrent miscarriages especially in recent years,the genetic and epigenetic factors underlying these problems are mostly unknown. Most of thepericentric inversions do not affect phenotypes of the individuals carrying balancedrearrangements. However, the pericentric inversions may cause chromosomally unbalancedsperm/ovum during the meiotic crossover leading to infertility or recurrent miscarriages. Inthis case report, we report a familial pericentric inv(12)(p11.2q14) in eight individuals withinfertility or recurrent miscarriages in three different families.
AU  - Karatas, Omer
AU  - KAYA, Murat
DO  - 10.18678/dtfd.544991
PY  - 2019
JO  - Düzce Tıp Fakültesi Dergisi
VL  - 21
IS  - 2
SN  - 1307-671X
SP  - 132
EP  - 135
DB  - TRDizin
UR  - http://search/yayin/detay/385938
ER  -