Does progesterone have protective effects on ovarian ischemia-reperfusion injury?

HISMIOĞULLARI, Adnan Adil; Islimye Taskin, Mine; BAŞER, Banu GÜLEÇ; Yay, Arzu Hanım; Adali, Ertan; TEFON ÖZTÜRK, BURCU EMİNE

doi:10.4274/jtgga.2017.0047

Does progesterone have protective effects on ovarian ischemia-reperfusion injury?

Banu GÜLEÇ BAŞER, (Balıkesir Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Balıkesir, Türkiye)

Mine İslimye TAŞKIN, (Balıkesir Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Balıkesir, Türkiye)

Ertan ADALI, (Balıkesir Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Balıkesir, Türkiye)

Burcu Emine TEFON ÖZTÜRK, (Balıkesir Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Balıkesir, Türkiye)

Adnan Adil HISMIOĞULLARI, (Balıkesir Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Balıkesir, Türkiye)

Arzu Hanım YAY (Erciyes Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Kayseri, Türkiye)

Journal of the Turkish-German Gynecological Association

4 0

Yıl: 2018 Cilt: 19 Sayı: 2 Sayfa Aralığı: 87 - 93 Metin Dili: İngilizce DOI: 10.4274/jtgga.2017.0047 İndeks Tarihi: 17-12-2020

Does progesterone have protective effects on ovarian ischemia-reperfusion injury?

Öz:

Objective: The aim of the present study was to evaluate the effects of progesterone (PG) against ovarian ischemia-reperfusion (I/R) injury through the evaluation of biochemical and histopathologic parameters.Material and Methods: Twenty-one female Wistar albino rats were divided into three groups. Group 1: Sham; group 2: I/R; group 3: I/R+PG (8 mg/kg). PG was administered intraperitoneally to the rats in group 3, 30 minutes before a detorsion operation. Ovarian I/R injury was evaluated in serum and tissue by using biochemical parameters including malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index, neutrophil gelatinase-associated lipocalin (NGAL) and immunofluorescence staining by using a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay.Results: Serum and tissue TOS levels were significantly lower in group 3 than in group 2. Tissue TAS levels were higher in group 3 than in group 2 (p<0.001). NGAL and MDA levels were similar between the groups. Histologic score, including vascular congestion, hemorrhage, polymorphonuclear neutrophils, and interstitial edema, was higher in group 2. Pre-treatment with PG decreased the score, but this difference was not statistically significant. The number of apoptotic cells was higher in group 2 than in groups 1 and 3. The TUNEL-positive cell number decreased with PG in group 3.Conclusion: Preoperative PG treatment might exert protective effects on ovarian I/R injury through its anti-apoptotic and antioxidative properties. (J Turk Ger Gynecol Assoc 2018; 19: 87-93)

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BAŞER B, Islimye Taskin M, Adali E, TEFON ÖZTÜRK B, HISMIOĞULLARI A, Yay A (2018). Does progesterone have protective effects on ovarian ischemia-reperfusion injury?. , 87 - 93. 10.4274/jtgga.2017.0047
Chicago	BAŞER Banu GÜLEÇ,Islimye Taskin Mine,Adali Ertan,TEFON ÖZTÜRK BURCU EMİNE,HISMIOĞULLARI Adnan Adil,Yay Arzu Hanım Does progesterone have protective effects on ovarian ischemia-reperfusion injury?. (2018): 87 - 93. 10.4274/jtgga.2017.0047
MLA	BAŞER Banu GÜLEÇ,Islimye Taskin Mine,Adali Ertan,TEFON ÖZTÜRK BURCU EMİNE,HISMIOĞULLARI Adnan Adil,Yay Arzu Hanım Does progesterone have protective effects on ovarian ischemia-reperfusion injury?. , 2018, ss.87 - 93. 10.4274/jtgga.2017.0047
AMA	BAŞER B,Islimye Taskin M,Adali E,TEFON ÖZTÜRK B,HISMIOĞULLARI A,Yay A Does progesterone have protective effects on ovarian ischemia-reperfusion injury?. . 2018; 87 - 93. 10.4274/jtgga.2017.0047
Vancouver	BAŞER B,Islimye Taskin M,Adali E,TEFON ÖZTÜRK B,HISMIOĞULLARI A,Yay A Does progesterone have protective effects on ovarian ischemia-reperfusion injury?. . 2018; 87 - 93. 10.4274/jtgga.2017.0047
IEEE	BAŞER B,Islimye Taskin M,Adali E,TEFON ÖZTÜRK B,HISMIOĞULLARI A,Yay A "Does progesterone have protective effects on ovarian ischemia-reperfusion injury?." , ss.87 - 93, 2018. 10.4274/jtgga.2017.0047
ISNAD	BAŞER, Banu GÜLEÇ vd. "Does progesterone have protective effects on ovarian ischemia-reperfusion injury?". (2018), 87-93. https://doi.org/10.4274/jtgga.2017.0047

APA	BAŞER B, Islimye Taskin M, Adali E, TEFON ÖZTÜRK B, HISMIOĞULLARI A, Yay A (2018). Does progesterone have protective effects on ovarian ischemia-reperfusion injury?. Journal of the Turkish-German Gynecological Association, 19(2), 87 - 93. 10.4274/jtgga.2017.0047
Chicago	BAŞER Banu GÜLEÇ,Islimye Taskin Mine,Adali Ertan,TEFON ÖZTÜRK BURCU EMİNE,HISMIOĞULLARI Adnan Adil,Yay Arzu Hanım Does progesterone have protective effects on ovarian ischemia-reperfusion injury?. Journal of the Turkish-German Gynecological Association 19, no.2 (2018): 87 - 93. 10.4274/jtgga.2017.0047
MLA	BAŞER Banu GÜLEÇ,Islimye Taskin Mine,Adali Ertan,TEFON ÖZTÜRK BURCU EMİNE,HISMIOĞULLARI Adnan Adil,Yay Arzu Hanım Does progesterone have protective effects on ovarian ischemia-reperfusion injury?. Journal of the Turkish-German Gynecological Association, vol.19, no.2, 2018, ss.87 - 93. 10.4274/jtgga.2017.0047
AMA	BAŞER B,Islimye Taskin M,Adali E,TEFON ÖZTÜRK B,HISMIOĞULLARI A,Yay A Does progesterone have protective effects on ovarian ischemia-reperfusion injury?. Journal of the Turkish-German Gynecological Association. 2018; 19(2): 87 - 93. 10.4274/jtgga.2017.0047
Vancouver	BAŞER B,Islimye Taskin M,Adali E,TEFON ÖZTÜRK B,HISMIOĞULLARI A,Yay A Does progesterone have protective effects on ovarian ischemia-reperfusion injury?. Journal of the Turkish-German Gynecological Association. 2018; 19(2): 87 - 93. 10.4274/jtgga.2017.0047
IEEE	BAŞER B,Islimye Taskin M,Adali E,TEFON ÖZTÜRK B,HISMIOĞULLARI A,Yay A "Does progesterone have protective effects on ovarian ischemia-reperfusion injury?." Journal of the Turkish-German Gynecological Association, 19, ss.87 - 93, 2018. 10.4274/jtgga.2017.0047
ISNAD	BAŞER, Banu GÜLEÇ vd. "Does progesterone have protective effects on ovarian ischemia-reperfusion injury?". Journal of the Turkish-German Gynecological Association 19/2 (2018), 87-93. https://doi.org/10.4274/jtgga.2017.0047