Yıl: 2020 Cilt: 32 Sayı: 1 Sayfa Aralığı: 38 - 43 Metin Dili: İngilizce DOI: 10.14744/agri.2019.16779 İndeks Tarihi: 17-12-2020

Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment

Öz:
Objectives: The primary objective of this study was to investigate the effects of Pulsed RF application in the genicular nerveon pain and function in patients with osteoarthritis (OA) and its side effects.Methods: This study was conducted between February 2018 and June 2018. Patients who were previously administered diagnostic blocks were evaluated a day later; a drop of at least 50% in numeric pain scores was considered a positive response, andthese patients were included in the Pulsed RF neurotomy procedures. Radiofrequency (RF) cannula was advanced towardstargeted nerves under the guidance of fluoroscopy. RF lesions were created by applying Pulsed RF treatment to the threegenicular nerves three times with five minutes intervals at 42 °C using NT1000 RF Generator. Following the Pulsed RF application, 2 mL 0.5% bupivacaine was injected into each genicular nerve as an anesthetic agent. VAS, pain DETECT scores, WOMACscores were evaluated preoperative baseline and postprocedure weeks 1, 4, and 12. Patient Global Impression of Change(PGIC) score was evaluated postprocedure weeks 12.Results: This study included 20 patients who were administered genicular nerve Pulsed RF. The mean age was 55.2±3.24 years,and F/M ratio was 12/8. Compared to the pre-procedure period, patients’ pain and function evaluation, WOMAC and VAS values decreased by approximately 50% at the end of the 12th week. No side effect was observed in any patients.Conclusion: Our findings suggest that Pulsed RF neurotomy of the genicular nerves is an efficient and safe treatment methodfor patients with chronic knee osteoarthritis.
Anahtar Kelime:

Kronik diz ağrısı tedavisinde fluoroskopi-destekli genikular sinir pulsed radyofrekans uygulaması

Öz:
Amaç: Bu çalışmamızda, primer olarak genikular sinire Pulsed RF uygulamasının diz osteoartrit (OA) hastalarında ağrı ve fonksiyon üzerine etkisini ve yan etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Bu çalışma, Şubat 2018-Haziran 2018 tarihleri arasında gerçekleştirildi. Daha önceden tanı bloğu yapılan hastalar bir gün sonra değerlendirildi, sayısal ağrı skorlarında en az %50 oranında bir düşüş pozitif yanıt olarak kabul edilerek bu hastalar Pulsed RF nörotomi işlemine dahil edildi. Hastaların genikular sinir (GN) dalları USG ile tanımlandı ve floroskopi klavuzluğunda hedef sinirlere radyofrekans (RF) kanülü ilerletildi. Ön-arka ve yan görüntü ile RF kanülü ucunun yeri görüntülendi. Ardından RF bir NT1000 RF Jeneratörü kullanılarak 42 °C’de üç kez beş dakika ara ile 3 genikular sinirlere Pulsed RF tedavisi uygulayarak RF lezyonları oluşturdu. Pulsed RF uygulaması sonrası, herbir genikular sinire 2ml lokal anestezik olarak bupivakain %0,5 enjekte edildi. İşlem öncesi bazal ve işlem sonrası 1, 4 ve 12. haftalardaki sonuç ölçümleri (VAS, pain DETECT skorları, WOMAC skorları) ve Patient Global Impression of Change (PGIC) skoru değerlendirildi. Bulgular: Genikular sinir Pulsed RF uygulanan 20 hasta dahil edildi. Hastaların yaşı (ort±SS) 55.2±3.24, K/E oranı ise 12/8 olarak değerlendirildi. Hastaların ağrı ve fonksiyon değerlendirme WOMAC skorları ve VAS değerleri işlem öncesi dönemle karşılaştırıldığında 12. haftanın sonunda yaklaşık %50 oranında azalma gözlenmiştir. Hiçbir hastada da yan etki gözlenmemiştir. Sonuç: Sonuç olarak, genikular sinirlerin pulsed RF nörotomisinin kronik diz OA hastaları için etkili ve güvenli bir tedavi yöntemi olduğunu düşünmekteyiz.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: A review of community burden and current use of primary health care. Ann Rheum Dis 2001;60(2):91–7.
  • 2. Crawford DC, Miller LE, Block JE. Conservative management of symptomatic knee osteoarthritis: A flawed strategy? Orthop Rev (Pavia) 2013;5(1):e2.
  • 3. Worland RL, Arredondo J, Angles F, Lopez-Jimenez F, Jessup DE. Thigh pain following tourniquet application in simultaneous bilateral total knee replacement arthroplasty. J Arthroplasty 1997;12(8):848–52.
  • 4. Nguyen US, Zhang Y, Zhu Y, Niu J, Zhang B, Felson DT. Increasing prevalence of knee pain and symptomatic knee osteoarthritis: Survey and cohort data. Ann Intern Med 2011;155(11):725–32.
  • 5. Santaguida PL, Hawker GA, Hudak PL, Glazier R, Mahomed NN, Kreder HJ, et al. Patient characteristics affecting the prognosis of total hip and knee joint arthroplasty: A systematic review. Can J Surg 2008;51(6):428–36.
  • 6. Runge C, Moriggl B, Børglum J, Bendtsen TF. The Spread of Ultrasound-Guided Injectate From the Adductor Canal to the Genicular Branch of the Posterior Obturator Nerve and the Popliteal Plexus: A Cadaveric Study. Reg Anesth Pain Med 2017;42(6):725–30.
  • 7. Choi WJ, Hwang SJ, Song JG, Leem JG, Kang YU, Park PH, et al. Radiofrequency treatment relieves chronic knee osteoarthritis pain: A double-blind randomized controlled trial. Pain 2011;152(3):481–7.
  • 8. Sarı S, Aydın ON, Turan Y, Özlülerden P, Efe U, Kurt Ömürlü İ. Which one is more effective for the clinical treatment of chronic pain in knee osteoarthritis: Radiofrequency neurotomy of the genicular nerves or intra-articular injection? Int J Rheum Dis 2018;21(10):1772–8.
  • 9. Kirdemir P, Çatav S, Alkaya Solmaz F. The genicular nerve: Radiofrequency lesion application for chronic knee pain. Turk J Med Sci 2017;47(1):268–72.
  • 10. Protzman NM, Gyi J, Malhotra AD, Kooch JE. Examining the feasibility of radiofrequency treatment for chronic knee pain after total knee arthroplasty. PM R 2014;6(4):373–6.
  • 11. Qudsi-Sinclair S, Borrás-Rubio E, Abellan-Guillén JF, Padilla Del Rey ML, Ruiz-Merino G. A comparison of genicular nerve treatment using either radiofrequency or analgesic block with corticosteroid for pain after a total knee arthroplasty: A double-blind, randomized clinical study. Pain Pract 2017;17(5):578–88.
  • 12. Kennedy JC, Alexander IJ, Hayes KC. Nerve supply of the human knee and its functional importance. Am J Sports Med 1982;10(6):329–35.
  • 13. Horner G, Dellon AL. Innervation of the human knee joint and implications for surgery. Clin Orthop Relat Res 1994;(301):221–6.
  • 14. Hirasawa Y, Okajima S, Ohta M, Tokioka T. Nerve distribution to the human knee joint: Anatomical and immunohistochemical study. Int Orthop 2000;24(1):1–4.
  • 15. Ikeuchi M, Ushida T, Izumi M, Tani T. Percutaneous radiofrequency treatment for refractory anteromedial pain of osteoarthritic knees. Pain Med 2011;12(4):546–51.
  • 16. Bellini M, Barbieri M. Cooled radiofrequency system relieves chronic knee osteoarthritis pain: the first case-series. Anaesthesiol Intensive Ther 2015;47(1):30–3.
  • 17. Rojhani S, Qureshi Z, Chhatre A. Water-Cooled Radiofrequency Provides Pain Relief, Decreases Disability, and Improves Quality of Life in Chronic Knee Osteoarthritis. Am J Phys Med Rehabil 2017;96(1):e5–e8.
  • 18. Shen WS, Xu XQ, Zhai NN, Zhou ZS, Shao J, Yu YH. Radiofrequency Thermocoagulation in Relieving Refractory Pain of Knee Osteoarthritis. Am J Ther 2017;24(6):e693–e700.
  • 19. Franco CD, Buvanendran A, Petersohn JD, Menzies RD, Menzies LP. Innervation of the Anterior Capsule of the Human Knee: Implications for Radiofrequency Ablation. Reg Anesth Pain Med 2015;40(4):363–8.
  • 20. Kesikburun S, Yaşar E, Uran A, Adigüzel E, Yilmaz B. Ultrasound-Guided Genicular Nerve Pulsed Radiofrequency Treatment For Painful Knee Osteoarthritis: A Preliminary Report. Pain Physician 2016;19(5):E751–9.
  • 21. Rea W, Kapur S, Mutagi H. Radiofrequency therapies in chronic pain. Contin Educ Anaesth Crit Care Pain 2011;11:35–8.
  • 22. An K, Elkassabany NM, Liu J. Dexamethasoneas adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaineinduced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model. PLoS One 2015;10(4):e0123459.
  • 23. Kim DH, Choi SS, Yoon SH, Lee SH, Seo DK, Lee IG, et al. Ultrasound-Guided Genicular Nerve Block for Knee Osteoarthritis: A Double-Blind, Randomized Controlled Trial of Local Anesthetic Alone or in Combination with Corticosteroid. Pain Physician 2018;21(1):41–52.
  • 24. Reddy RD, McCormick ZL, Marshall B, Mattie R, Walega DR. Cooled Radiofrequency Ablation of Genicular Nerves for Knee Osteoarthritis Pain: A Protocol for Patient Selection and Case Series. Anesth Pain Med 2016;6(6):e39696.
  • 25. McCormick ZL, Reddy R, Korn M, Dayanim D, Syed RH, Bhave M, et al. A Prospective Randomized Trial of Prognostic Genicular Nerve Blocks to Determine the Predictive Value for the Outcome of Cooled Radiofrequency Ablation for Chronic Knee Pain Due to Osteoarthritis. Pain Med 2018;19(8):1628–38.
  • 26. Vas L, Khandagale N, Pai R. Successful management of chronic post-surgical pain following total knee replacement. Pain Med 2014;15(10):1781–5.
  • 27. Freynhagen R, Baron R, Gockel U, Tölle TR. Pain DETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin 2006;22(10):1911–20.
APA arican s, BÜYÜKBEZİRCİ G, Akkoyun Sert Ö, TUNCER UZUN S, REİSLİ R (2020). Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment. , 38 - 43. 10.14744/agri.2019.16779
Chicago arican sule,BÜYÜKBEZİRCİ Gülçin,Akkoyun Sert Özlem,TUNCER UZUN SEMA,REİSLİ RUHİYE Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment. (2020): 38 - 43. 10.14744/agri.2019.16779
MLA arican sule,BÜYÜKBEZİRCİ Gülçin,Akkoyun Sert Özlem,TUNCER UZUN SEMA,REİSLİ RUHİYE Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment. , 2020, ss.38 - 43. 10.14744/agri.2019.16779
AMA arican s,BÜYÜKBEZİRCİ G,Akkoyun Sert Ö,TUNCER UZUN S,REİSLİ R Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment. . 2020; 38 - 43. 10.14744/agri.2019.16779
Vancouver arican s,BÜYÜKBEZİRCİ G,Akkoyun Sert Ö,TUNCER UZUN S,REİSLİ R Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment. . 2020; 38 - 43. 10.14744/agri.2019.16779
IEEE arican s,BÜYÜKBEZİRCİ G,Akkoyun Sert Ö,TUNCER UZUN S,REİSLİ R "Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment." , ss.38 - 43, 2020. 10.14744/agri.2019.16779
ISNAD arican, sule vd. "Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment". (2020), 38-43. https://doi.org/10.14744/agri.2019.16779
APA arican s, BÜYÜKBEZİRCİ G, Akkoyun Sert Ö, TUNCER UZUN S, REİSLİ R (2020). Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment. Ağrı, 32(1), 38 - 43. 10.14744/agri.2019.16779
Chicago arican sule,BÜYÜKBEZİRCİ Gülçin,Akkoyun Sert Özlem,TUNCER UZUN SEMA,REİSLİ RUHİYE Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment. Ağrı 32, no.1 (2020): 38 - 43. 10.14744/agri.2019.16779
MLA arican sule,BÜYÜKBEZİRCİ Gülçin,Akkoyun Sert Özlem,TUNCER UZUN SEMA,REİSLİ RUHİYE Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment. Ağrı, vol.32, no.1, 2020, ss.38 - 43. 10.14744/agri.2019.16779
AMA arican s,BÜYÜKBEZİRCİ G,Akkoyun Sert Ö,TUNCER UZUN S,REİSLİ R Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment. Ağrı. 2020; 32(1): 38 - 43. 10.14744/agri.2019.16779
Vancouver arican s,BÜYÜKBEZİRCİ G,Akkoyun Sert Ö,TUNCER UZUN S,REİSLİ R Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment. Ağrı. 2020; 32(1): 38 - 43. 10.14744/agri.2019.16779
IEEE arican s,BÜYÜKBEZİRCİ G,Akkoyun Sert Ö,TUNCER UZUN S,REİSLİ R "Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment." Ağrı, 32, ss.38 - 43, 2020. 10.14744/agri.2019.16779
ISNAD arican, sule vd. "Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment". Ağrı 32/1 (2020), 38-43. https://doi.org/10.14744/agri.2019.16779