Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients

YALÇIN, Kadir Serkan; Besirbellioglu, Bulent Ahmet; KÜÇÜKAY, Murat Bülent; ÇİÇEK, OKAN; ALANLI, Recep

doi:10.18678/dtfd.780011

Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients

Recep ALANLI, (Lokman Hekim Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Murat Bülent KÜÇÜKAY, (Lokman Hekim Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Okan ÇİÇEK, (Ankara Eğitim ve Araştırma Hastanesi Radyoloji Bölümü, Ankara Türkiye)

Kadir Serkan YALÇIN, (Lokman Hekim Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Bülent Ahmet BEŞİRBELLİOĞLU (Lokman Hekim Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları Bölümü, Ankara, Türkiye)

Düzce Tıp Fakültesi Dergisi

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Yıl: 2020 Cilt: 22 Sayı: S1 Sayfa Aralığı: 39 - 43 Metin Dili: İngilizce DOI: 10.18678/dtfd.780011 İndeks Tarihi: 18-12-2020

Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients

Öz:

Aim: The aim of this study was to investigate concordance between polymerase chain reaction(PCR) test results and early thorax computed tomography (CT) findings of the patients inwhom coronavirus disease 2019 (COVID-19) was suspected after evaluation of theircomplaints and physical examination findings.Material and Methods: One hundred and fourteen patients with suspicion of COVID-19,evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) existence withPCR test and performed thorax CT in the first 48 hours, between April and July 2020, wereenrolled in this study retrospectively. Demographic characteristics, laboratory parameters andthorax CT findings of PCR positive and negative patients were compared. If patients hadnegative PCR test results, but clinical suspicion for COVID-19 persisted, additional PCRsamples were tested at 48-hour intervals.Results: Interlobular septal thickening was more frequent in PCR positive patients (p=0.043).There was no significant thorax CT finding in 16 (28.6%) PCR positive and 14 (24.1%) PCRnegative patients. Bilateral, peripheral and multilobar ground glass opacifications, consolidationand interlobular septal thickening were the most frequent findings in both groups. Neutrophil(p<0.001) and platelet counts (p=0.038) were significantly lower in PCR positive group.Conclusion: The thorax CT findings of the patients whose PCR tests were positive or negativewere greatly similar except for interlobular septal thickening, thus thorax CT should not beused alone in the diagnosis of COVID-19 especially in early stages. In decision making,symptoms, laboratory and CT findings and PCR tests of patients must be evaluated all together.

Anahtar Kelime:

COVID-19 Hastalarında Erken Dönemde Çekilen Akciğer Bilgisayarlı Tomografi Bulguları ile PCR Testinin Uyumluluğu

Öz:

Amaç: Bu çalışmanın amacı yakınmaları ve fizik muayene bulgularının değerlendirilmesi sonrasında koronavirüs hastalığı 2019 (coronavirus disease 2019, COVID-19) ön tanısı konulan hastaların erken dönemde çekilen akciğer bilgisayarlı tomografi (BT) bulguları ile polimeraz zincir reaksiyonu (polymerase chain reaction, PCR) testi sonuçları arasındaki uyumluluğun araştırılmasıdır. Gereç ve Yöntemler: Nisan ile Temmuz 2020 tarihleri arasında COVID-19 şüphesi olan, PCR testi ile şiddetli akut solunum yolu sendromu koronavirüsü 2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) varlığı açısından değerlendirilen ve ilk 48 saatte akciğer BT yapılan 114 hasta geriye dönük olarak bu çalışmaya alındı. PCR testi pozitif ve negatif olan hastaların demografik özellikleri, laboratuvar parametreleri ve akciğer BT bulguları karşılaştırıldı. PCR testi negatif saptanıp klinik şüphesi devam eden hastalarda 48 saatlik aralıklar ile yeni PCR örnekleri alındı. Bulgular: PCR pozitif hastalarda interlobüler septal kalınlaşma daha fazla bulundu (p=0,043). PCR pozitif olan 16 (%28,6) ve PCR negatif olan 14 (%24,1) hastada tomografide anlamlı bir bulgu saptanmadı. Her iki grupta da en sık bulgular; bilateral, periferal ve multilober yerleşimli buzlu cam görünümü, konsolidasyon ve interlobuler septal kalınlaşma idi. PCR pozitif olan grupta nötrofil (p<0,001) ve trombosit sayısı (p=0,038) anlamlı olarak daha düşük saptandı. Sonuç: PCR testi pozitif veya negatif saptanan hastaların interlobular septal kalınlaşma dışındaki akciğer BT bulguları oldukça benzer idi, dolayısıyla COVID-19 tanısında özellikle erken dönemlerde akciğer BT tek başına kullanılmamalıdır. Karar verme esnasında, hastaların semptom, laboratuvar ve BT bulguları ile PCR testi hep birlikte değerlendirilmelidir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ALANLI R, KÜÇÜKAY M, ÇİÇEK O, YALÇIN K, Besirbellioglu B (2020). Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients. , 39 - 43. 10.18678/dtfd.780011
Chicago	ALANLI Recep,KÜÇÜKAY Murat Bülent,ÇİÇEK OKAN,YALÇIN Kadir Serkan,Besirbellioglu Bulent Ahmet Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients. (2020): 39 - 43. 10.18678/dtfd.780011
MLA	ALANLI Recep,KÜÇÜKAY Murat Bülent,ÇİÇEK OKAN,YALÇIN Kadir Serkan,Besirbellioglu Bulent Ahmet Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients. , 2020, ss.39 - 43. 10.18678/dtfd.780011
AMA	ALANLI R,KÜÇÜKAY M,ÇİÇEK O,YALÇIN K,Besirbellioglu B Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients. . 2020; 39 - 43. 10.18678/dtfd.780011
Vancouver	ALANLI R,KÜÇÜKAY M,ÇİÇEK O,YALÇIN K,Besirbellioglu B Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients. . 2020; 39 - 43. 10.18678/dtfd.780011
IEEE	ALANLI R,KÜÇÜKAY M,ÇİÇEK O,YALÇIN K,Besirbellioglu B "Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients." , ss.39 - 43, 2020. 10.18678/dtfd.780011
ISNAD	ALANLI, Recep vd. "Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients". (2020), 39-43. https://doi.org/10.18678/dtfd.780011

APA	ALANLI R, KÜÇÜKAY M, ÇİÇEK O, YALÇIN K, Besirbellioglu B (2020). Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients. Düzce Tıp Fakültesi Dergisi, 22(S1), 39 - 43. 10.18678/dtfd.780011
Chicago	ALANLI Recep,KÜÇÜKAY Murat Bülent,ÇİÇEK OKAN,YALÇIN Kadir Serkan,Besirbellioglu Bulent Ahmet Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients. Düzce Tıp Fakültesi Dergisi 22, no.S1 (2020): 39 - 43. 10.18678/dtfd.780011
MLA	ALANLI Recep,KÜÇÜKAY Murat Bülent,ÇİÇEK OKAN,YALÇIN Kadir Serkan,Besirbellioglu Bulent Ahmet Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients. Düzce Tıp Fakültesi Dergisi, vol.22, no.S1, 2020, ss.39 - 43. 10.18678/dtfd.780011
AMA	ALANLI R,KÜÇÜKAY M,ÇİÇEK O,YALÇIN K,Besirbellioglu B Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients. Düzce Tıp Fakültesi Dergisi. 2020; 22(S1): 39 - 43. 10.18678/dtfd.780011
Vancouver	ALANLI R,KÜÇÜKAY M,ÇİÇEK O,YALÇIN K,Besirbellioglu B Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients. Düzce Tıp Fakültesi Dergisi. 2020; 22(S1): 39 - 43. 10.18678/dtfd.780011
IEEE	ALANLI R,KÜÇÜKAY M,ÇİÇEK O,YALÇIN K,Besirbellioglu B "Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients." Düzce Tıp Fakültesi Dergisi, 22, ss.39 - 43, 2020. 10.18678/dtfd.780011
ISNAD	ALANLI, Recep vd. "Concordance of PCR and Early Thorax Computed Tomography Findings in COVID-19 Patients". Düzce Tıp Fakültesi Dergisi 22/S1 (2020), 39-43. https://doi.org/10.18678/dtfd.780011