Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia
Yıl: 2020 Cilt: 31 Sayı: 1 Sayfa Aralığı: 54 - 58 Metin Dili: İngilizce DOI: 10.14744/scie.2019.48569 İndeks Tarihi: 28-12-2020
Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia
Öz: Objective: In recent years, carbapenem-resistant Klebsiella pneumoniae infections havebecome an important health problem in our country and all over the world. In this study,we aimed to identify the risk factors of carbapenem-resistant K. pneumoniae bacteremia.Methods: Patients who suffered from Klebsiella pneumoniae bacteremia between December2016 and May 2018 were included prospectively in this study. Patients were divided intogroups according to carbapenem resistance and risk factors were analyzed under variableand multivariable logistic regression model.Results: Of the fifty-three patients were included in this study, 27 patients infected withcarbapenem-resistant K. pneumoniae and 26 patients infected with carbapenem-suspectibleK. pneumoniae. Risk factors for carbapenem-resistant K. pneumoniae bacteremia accordingto univariate analysis were listed prior hospitalization (p=0.043; OR=3.20; 95% CI: 1.04–9.85), admission to intensive care unit (p=0.001; OR=10.91; 955 CI: 2.61–45.6), use of beta-lactams/beta-lactamase inhibitor combination (p<0.001; OR=41.67; 95% CI: 7.57–229.2)and use of glycopeptides (p=0.001; OR=7.92; 95% CI: 2.31–27.1). Before hospitalization(p=0.016; OR=9.64; 95% CI: 1.54–60.46) and use of beta-lactams/beta-lactamase, inhibitorcombination (p<0.001; OR=38.45; 95% CI: 6.04–244.85) were identified as independent riskfactors for carbapenem resistance in multivariate analysis.Conclusion: According to our study, before hospitalization, the use of beta-lactams/betalactamaseinhibitor combination was the major risk factor for carbapenem-resistant Klebsiellapneumoniae bacteremia.
Anahtar Kelime: Klebsiella Pneumoniae Bakteriyemilerinde Karbapenem Direnci İçin Risk Faktörlerinin Değerlendirilmesi
Öz: Amaç: Son yıllarda artan karbapenem direnci ile birlikte Klebsiella pneumoniae enfeksiyonları ülkemizde ve tüm dünyada önemli bir sağlık problemi haline gelmiştir. Bu çalışmada, Klebsiella pneumoniae bakteriyemilerinde karbapenem direnci için risk faktörlerini belirlemeyi amaçladık. Gereç ve Yöntem: Aralık 2016–Mayıs 2018 tarihleri arasında kan kültüründe Klebsiella pneumoniae üremesi olan hastalar ileriye yönelik olarak çalışmaya dahil edildi. Olgular karbapenem direnç durumuna göre gruplara ayrılarak; tek ve çok değişkenli regresyon modeli ile karbapenem direnci için risk faktörleri analiz edildi. Bulgular: Çalışmaya dahil edilen 53 olgunun; 27’si karbapenem dirençli, 26’sı ise karbapenem duyarlı Klebsiella pneumoniae izolatı ile enfekte idi. Yapılan tek değişken analiz sonuçlarına göre; hastaneye yatış öyküsü [p=0.043; Odds ratio (OR)=3.20; %95 güven aralığı (%95 GA): 1.04–9.85], yoğun bakım ünitesinde (YBÜ) yatıyor olmak (p=0.001; OR=10.91; %95 GA 2.61–45.6), beta-laktam/beta-laktam inhibitörü kombinasyonu kullanımı (p<0.001; OR=41.67; %95 GA 7.57–229.2), glikopeptid kullanımı (p=0.001; OR=7.92; %95 GA 2.31–27.1) Klebsiella pneumoniae bakteriyemilerinde karbapenem direnci için istatistiksel olarak anlamlı bulundu. Çok değişkenli analiz sonucunda ise; hastaneye yatış öyküsü (p=0.016; OR=9.64; %95 GA: 1.54–60.46), beta-laktam/beta-laktam inhibitörü kombinasyonu kullanımı (p<0.001; OR=38.45; %95 GA 6.04–244.85) karbapenem direnci açısından anlamlı bağımsız risk faktörü olarak saptandı. Sonuç: Yaptığımız çalışmada, hastanede yatış öyküsü, beta-laktam/beta-laktamaz inhibitörü kombinasyonu kullanımı Klebsiella pneumoniae bakteriyemilerinde karbapenem direnci için en önemli risk faktörü olarak bulunmuştur.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KIRAN P, Gencer S, Batirel A (2020). Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia. , 54 - 58. 10.14744/scie.2019.48569 |
| Chicago | KIRAN Pınar,Gencer Serap,Batirel Ayse Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia. (2020): 54 - 58. 10.14744/scie.2019.48569 |
| MLA | KIRAN Pınar,Gencer Serap,Batirel Ayse Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia. , 2020, ss.54 - 58. 10.14744/scie.2019.48569 |
| AMA | KIRAN P,Gencer S,Batirel A Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia. . 2020; 54 - 58. 10.14744/scie.2019.48569 |
| Vancouver | KIRAN P,Gencer S,Batirel A Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia. . 2020; 54 - 58. 10.14744/scie.2019.48569 |
| IEEE | KIRAN P,Gencer S,Batirel A "Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia." , ss.54 - 58, 2020. 10.14744/scie.2019.48569 |
| ISNAD | KIRAN, Pınar vd. "Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia". (2020), 54-58. https://doi.org/10.14744/scie.2019.48569 |
| APA | KIRAN P, Gencer S, Batirel A (2020). Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia. Southern Clinics of Istanbul Eurasia, 31(1), 54 - 58. 10.14744/scie.2019.48569 |
| Chicago | KIRAN Pınar,Gencer Serap,Batirel Ayse Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia. Southern Clinics of Istanbul Eurasia 31, no.1 (2020): 54 - 58. 10.14744/scie.2019.48569 |
| MLA | KIRAN Pınar,Gencer Serap,Batirel Ayse Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia. Southern Clinics of Istanbul Eurasia, vol.31, no.1, 2020, ss.54 - 58. 10.14744/scie.2019.48569 |
| AMA | KIRAN P,Gencer S,Batirel A Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia. Southern Clinics of Istanbul Eurasia. 2020; 31(1): 54 - 58. 10.14744/scie.2019.48569 |
| Vancouver | KIRAN P,Gencer S,Batirel A Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia. Southern Clinics of Istanbul Eurasia. 2020; 31(1): 54 - 58. 10.14744/scie.2019.48569 |
| IEEE | KIRAN P,Gencer S,Batirel A "Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia." Southern Clinics of Istanbul Eurasia, 31, ss.54 - 58, 2020. 10.14744/scie.2019.48569 |
| ISNAD | KIRAN, Pınar vd. "Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia". Southern Clinics of Istanbul Eurasia 31/1 (2020), 54-58. https://doi.org/10.14744/scie.2019.48569 |
