TY  - JOUR
TI  - The investigation of oxidative stress parameters in patients with lipoid proteinosis
AB  - Background: This study aims to investigate the role of oxidative stress in pathogenesis of Lipoid Proteinosis(LP) by measuring the parameters of serum oxidative stress such as total antioxidant status (TAS), totaloxidant status (TOS), advanced oxidation protein products (AOPP), oxidative stress index (OSI), ferric reducingantioxidant power (FRAP), lipid hydroperoxide (LOOH) and total free sulfhydryl groups (Total-SH).Methods: Fourteen patients with LP diagnosed clinically, radiologically and histopathologically and 14 sex-,age- and body mass index- matched healthy volunteers were included in this prospective case-control study.Serum TAS, TOS, AOPP, FRAP, LOOH and Total-SH were measured spectrophotometrically and OSI werecalculated.Results: Cases with LP had significantly lower serum levels of TAS, FRAP and Total –SH (p< 0.001, for each)and higher levels of OSI, AOPP and LOOH (p= 0.001, p= 0.018, and p= 0.047, respectively). Serum TOSlevels were higher in the LP group when compared to that of the control group, but it was not statisticallysignificant (p= 0.081). ROC analysis demonstrated that TAS, FRAP, Total-SH and OSI levels independentlypredicted LP with strong sensitivity and specificity.Conclusion: Our results demonstrate that decreased levels of antioxidant parameters and increased levels ofoxidant parameters might be used as an ancillary laboratory tests in the diagnosis of LP disease.
AU  - Aksoy, Mustafa
AU  - Celik, Hakim
AU  - koyuncu, ismail
AU  - An, Isa
PY  - 2019
JO  - Harran Üniversitesi Tıp Fakültesi Dergisi
VL  - 16
IS  - 1
SN  - 1304-9623
SP  - 1
EP  - 7
DB  - TRDizin
UR  - http://search/yayin/detay/389547
ER  -