Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells
Yıl: 2019 Cilt: 3 Sayı: 2 Sayfa Aralığı: 113 - 120 Metin Dili: İngilizce DOI: 10.32571/ijct.613536 İndeks Tarihi: 07-01-2021
Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells
Öz: Prostate cancer is caused by uncontrolled growth of cells in the prostate gland. The aim of this study was to determine the cytotoxic activity of titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles (NPs) and TiO2 + ZnO nanocomposite (NC) in human prostate cancer cell line (DU-145) and healthy mouse fibroblast cell line (L-929). In the study, TiO2 and ZnO NPs and TiO2 + ZnO NC were synthesized. Cytotoxic activities of NC and NPs was then analyzed in human prostate cancer cell line (DU-145) and healthy mouse fibroblast cell lines (L-929) using the MTT method. TiO2, ZnO and TiO2 + ZnO IC50 values were determined in DU-145 and L-929 cell cells (n = 6). TiO2 + ZnO NC in the Du-145 cell line was found as the most active, having statistically significant (***p < 0.0001, **p ˂ 0.001 and **p ˂ 0.01).
Anahtar Kelime: Çinko oksit/titanyum dioksit nanopartiküllerin prostat kanser hücreleri üzerinde sitotoksik aktivitesi
Öz: Prostat kanseri, prostat bezindeki hücrelerin kontrolsüz büyümesinden kaynaklanır. Bu çalışmanın amacı, insan prostat kanseri hücre hattında (DU-145) ve sağlıklı fare fibroblast hücre hattında (L-929) titanyum dioksit (TiO2)ve çinko oksit (ZnO)nanopartikülleri(NPs)ve TiO2+ZnO nanokompozit (NK) 'in sitotoksik aktivitesini belirlemektir. Çalışmada TiO2ve ZnO NPsve TiO2+ZnO NK sentezlenmiştir. NK ve NPs’ lerinsitotoksikaktiviteleri,dahasonraMTTmetodu kullanılarak insan prostat kanser hücre hattı(DU-145)ve sağlıklı mouse fibroblast hücre hatlarında (L-929)analiz edilmiştir. DU-145 ve L-929 hücre hücrelerinde TiO2, ZnO ve TiO2+ZnO IC50değerleri belirlenmiştir(n=6). Du-145 hücre hattında Ti02 + ZnO NK, istatistiksel öneme sahip olarak en aktif olarak bulunmuştur (*** p <0.0001, **p ˂ 0.001 ve ** p ˂ 0.01)
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Hui-Ping, L.; Ching-Yu, L.; Chun-Chieh, L.; Liang-Cheng, Su Chieh, H.; Ying-Yu, K.; Jen-Chih, T.; Jong-Ming, H.; Chi-Kuan, C.; Chih-Pin, C. Int. J. Mol. Sci. 2013, 14, 5264-5283.
- 2. Szliszka, E.; Krol, W. Oncol. Rep. 2011, 26, 533-541.
- 3. Cimino, S.; Sortino, G.; Favilla, V.; Castelli, T.; Madonia, M.; Sansalone, S.; Russo, GI.; Morgia, G. Oxid Med Cell Longev. 2012, ID 632959, 8 pages.
- 4. Skandalis, S. S.; Gialeli, C.; Theocharis, A. D.; Karamanos, N. K. Adv. Cancer Res. 2014, 123, 277-317.
- 5. Jabir, N. R.; Tabrez, S.; Ashraf, G. M.; Shakil, S.; Damanhouri, G. A.; Kamal, M. A. Int. J. Nanomedicine 2012, 7, 4391-4408.
- 6. J. Wu, Y.; Wang, X.; Yang, Y.; Liu, J.; Yang, R. Nanotechnology 2012, 10, 23-35.
- 7. Yang, D.; Wenzhi, R.; Yaqian, L.; Qian, Z.; Leyong, Z.; Chongwei, C.; Aiguo, W.; Jie, T. Royal Soc. Chem. 2015, 16, 38-59.
- 8. Rozhkova, EA.; Ulasov, I.; Lai, B.; Dimitrijevic, NM.; Lesniak, MS.; Rajh, T. Nano Lett. 2009, 9, 3337-3342.
- 9. S. Shen, X.; Guo, L.; Wu, M.; Wang, X.; Wang, F.; Kong, H.; Shen, M.; Xie, Y. J. Mater. Chem. 2014, 2, 5775-5784.
- 10. Zhao, C.; Zhang, X.; Zheng, Y. J. Photochem. Photobiol. B: Biology 2018, 183, 142-146.
- 11. Carp, O.; Huisman, C. L.; Reller, A. Prog. Solid State Chem. 2004, 32, 33-177.
- 12. Zhou, J.; Xu, N. S.; Wang, Z. L. Adv. Mater. 2006, 18 (18), 2432-2435.
- 13. Tas, A.; Cakmak, N. K.; Silig, Y. Inter. J. Modern Res. Eng. Technol. 2018, 3.
- 14. Rrajendar, V.; Raghu, Y.; Rajitha, B.; Chakra, C. S.; Rao, K. V.; Park, S. H. J. Ovonic Res. 2017, 13.
- 15. Bolukbasi Sahin, S.; Keklikcioglu Cakmak, N.; Tas, A.; Ozmen, E.; Cevik, E.; Gumus, E.; Silig, Y. Int. J. Sci. Technol. Res. 2018, 4 (8), 78-84.
- 16. Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, J. T.; Bokesch, H.; Kenney, S.; Boyd, M. R. J. Natl. Cancer Inst. 1990, 82, 1107-1112.
- 17. Von der Kammer, F, Ottofuelling, S.; Hofmann, T. Environ. Pollut. 2010, 158, 3472-3481.
- 18. McNeil, S. E. J. Leukoc. Biol. 2005, 78, 585-594.
- 19. Bisht, G.; Rayamajhi, S. Nanobiomedicine 2016, 3, 3-9.
- 20. Cho, W. S; Kang, B. C; Lee, J. K.; Jeong, J.; Che, J. H; Seok, S. H. Part Fibre Toxicol. 2013, 10, 9.
- 21. Hanley, C.; Layne, J.; Punnoose, A.; Reddy, K. M.; Coombs, I.; Coombs, I.; Coombs, A.; Feris, K.; Wingett, D. Nanotechnology 2008, 19 (29), 295103.
- 22. Kansara, K.; Patel, P.; Shah, D.; Shukla, R. K.; Singh, S.; Kumar, A.; Dhawan, A. Environ. Mol. Mutagen. 2015, 56 (2), 204-217.
- 23. Tomasina, J.; Poulain, L.; Abeilard, E.; Giffard, F.; Brotin, E.; Carduner, L. Malzert-Fréon, A. Int. J. Pharm. 2013, 458 (1), 197-207.
- 24. Fadoju, O.; Ogunsuyi, O.; Akanni, O.; Alabi, O.; Alimba, C.; Adaramoye, O. Bakare, A. Environ. Toxicol. Pharm. 2019, 103204.
| APA | TAŞ A, Keklikcioğlu Çakmak N, Ağbektaş T, Silig Y (2019). Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells. , 113 - 120. 10.32571/ijct.613536 |
| Chicago | TAŞ Ayca,Keklikcioğlu Çakmak Neşe,Ağbektaş Tuğba,Silig Yavuz Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells. (2019): 113 - 120. 10.32571/ijct.613536 |
| MLA | TAŞ Ayca,Keklikcioğlu Çakmak Neşe,Ağbektaş Tuğba,Silig Yavuz Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells. , 2019, ss.113 - 120. 10.32571/ijct.613536 |
| AMA | TAŞ A,Keklikcioğlu Çakmak N,Ağbektaş T,Silig Y Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells. . 2019; 113 - 120. 10.32571/ijct.613536 |
| Vancouver | TAŞ A,Keklikcioğlu Çakmak N,Ağbektaş T,Silig Y Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells. . 2019; 113 - 120. 10.32571/ijct.613536 |
| IEEE | TAŞ A,Keklikcioğlu Çakmak N,Ağbektaş T,Silig Y "Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells." , ss.113 - 120, 2019. 10.32571/ijct.613536 |
| ISNAD | TAŞ, Ayca vd. "Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells". (2019), 113-120. https://doi.org/10.32571/ijct.613536 |
| APA | TAŞ A, Keklikcioğlu Çakmak N, Ağbektaş T, Silig Y (2019). Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells. International Journal of Chemistry and Technology (IJCT), 3(2), 113 - 120. 10.32571/ijct.613536 |
| Chicago | TAŞ Ayca,Keklikcioğlu Çakmak Neşe,Ağbektaş Tuğba,Silig Yavuz Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells. International Journal of Chemistry and Technology (IJCT) 3, no.2 (2019): 113 - 120. 10.32571/ijct.613536 |
| MLA | TAŞ Ayca,Keklikcioğlu Çakmak Neşe,Ağbektaş Tuğba,Silig Yavuz Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells. International Journal of Chemistry and Technology (IJCT), vol.3, no.2, 2019, ss.113 - 120. 10.32571/ijct.613536 |
| AMA | TAŞ A,Keklikcioğlu Çakmak N,Ağbektaş T,Silig Y Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells. International Journal of Chemistry and Technology (IJCT). 2019; 3(2): 113 - 120. 10.32571/ijct.613536 |
| Vancouver | TAŞ A,Keklikcioğlu Çakmak N,Ağbektaş T,Silig Y Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells. International Journal of Chemistry and Technology (IJCT). 2019; 3(2): 113 - 120. 10.32571/ijct.613536 |
| IEEE | TAŞ A,Keklikcioğlu Çakmak N,Ağbektaş T,Silig Y "Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells." International Journal of Chemistry and Technology (IJCT), 3, ss.113 - 120, 2019. 10.32571/ijct.613536 |
| ISNAD | TAŞ, Ayca vd. "Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells". International Journal of Chemistry and Technology (IJCT) 3/2 (2019), 113-120. https://doi.org/10.32571/ijct.613536 |
