TY  - JOUR
TI  - Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells
AB  - Prostate cancer is caused by uncontrolled growth of cells in the prostate gland. The aim of this study was to determine the cytotoxic activity of titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles (NPs) and TiO2 + ZnO nanocomposite (NC) in human prostate cancer cell line (DU-145) and healthy mouse fibroblast cell line (L-929). In the study, TiO2 and ZnO NPs and TiO2 + ZnO NC were synthesized. Cytotoxic activities of NC and NPs was then analyzed in human prostate cancer cell line (DU-145) and healthy mouse fibroblast cell lines (L-929) using the MTT method. TiO2, ZnO and TiO2 + ZnO IC50 values were determined in DU-145 and L-929 cell cells (n = 6). TiO2 + ZnO NC in the Du-145 cell line was found as the most active, having statistically significant (***p < 0.0001, **p ˂ 0.001 and **p ˂ 0.01).
AU  - Ağbektaş, Tuğba
AU  - Keklikcioğlu Çakmak, Neşe
AU  - Silig, Yavuz
AU  - TAŞ, Ayca
DO  - 10.32571/ijct.613536
PY  - 2019
JO  - International Journal of Chemistry and Technology (IJCT)
VL  - 3
IS  - 2
SN  - 2602-277X
SP  - 113
EP  - 120
DB  - TRDizin
UR  - http://search/yayin/detay/390001
ER  -