ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET

akgeyik, emrah; Çelebier, Mustafa; Sahin, Selma; KAYNAK, Mustafa Sinan; Berkman, Murat Sami; Gençer, Ayşe

doi:10.18036/estubtdc.661691

ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET

Ayşe GENCER, (İnönü Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Malatya, Türkiye)

Emrah AKGEYİK, (Bozok Üniversitesi, Bilim ve Teknoloji Uygulama ve Araştırma Merkezi (BİLTEM), Yozgat, Türkiye)

Mustafa Sinan KAYNAK, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Bölümü, Eskişehir, Türkiye)

Mustafa ÇELEBİER, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, Ankara, Türkiye)

Murat Sami BERKMAN, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Bölümü, Eskişehir, Türkiye)

Selma ŞAHİN (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Ankara, Türkiye)

Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online)

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Yıl: 2020 Cilt: 9 Sayı: 2 Sayfa Aralığı: 179 - 189 Metin Dili: İngilizce DOI: 10.18036/estubtdc.661691 İndeks Tarihi: 11-01-2021

ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET

Öz:

Cardioselective β-adrenergic blocker metoprolol tartrate, is used in the treatment of different diseases such as cardiacarrhythmias, hypertension, heart failure, angina pectoris, migraine, and hyperthyroidism. Beside dosage forms of the parenteralampoule and conventional tablets of different manufacturers, there are extended release tablets of metoprolol tartrate in theTurkish Drug Market. In this research work, comparative quality control studies of metoprolol tartrate extended release tablets(original and generic) produced by two different pharmaceutical companies in the Turkey were carried out and evaluatedaccording to the related guidelines. Thickness and diameter, hardness, weight variation, friability, content uniformity anddissolution rate were examined as quality control parameters. A new validated HPLC method for the quantification ofmetoprolol tartrate has been developed. An ACE column (C18, 5 µm, 250x4.6 mm) and acetonitrile:phosphate buffer (30:70,v/v) mobile phase were used for the determination of metoprolol tartrate. The tablets showed extended release for 8 hours(70.74% release from drug A, 76.87% from the drug B). Both products have acceptable hardness, friability and weight variationvalues. Content of the active ingredient of the tablets was consistent with label claim (99.45% for drug A and 96.45% for drugB). The dissolution data were evaluated by model dependent and model independent methods using DDSolver program. Theobtained results showed that release kinetics of both drugs were well fitted with the Korsmeyer-Peppas model.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Gençer A, akgeyik e, KAYNAK M, Çelebier M, Berkman M, Sahin S (2020). ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET. , 179 - 189. 10.18036/estubtdc.661691
Chicago	Gençer Ayşe,akgeyik emrah,KAYNAK Mustafa Sinan,Çelebier Mustafa,Berkman Murat Sami,Sahin Selma ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET. (2020): 179 - 189. 10.18036/estubtdc.661691
MLA	Gençer Ayşe,akgeyik emrah,KAYNAK Mustafa Sinan,Çelebier Mustafa,Berkman Murat Sami,Sahin Selma ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET. , 2020, ss.179 - 189. 10.18036/estubtdc.661691
AMA	Gençer A,akgeyik e,KAYNAK M,Çelebier M,Berkman M,Sahin S ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET. . 2020; 179 - 189. 10.18036/estubtdc.661691
Vancouver	Gençer A,akgeyik e,KAYNAK M,Çelebier M,Berkman M,Sahin S ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET. . 2020; 179 - 189. 10.18036/estubtdc.661691
IEEE	Gençer A,akgeyik e,KAYNAK M,Çelebier M,Berkman M,Sahin S "ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET." , ss.179 - 189, 2020. 10.18036/estubtdc.661691
ISNAD	Gençer, Ayşe vd. "ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET". (2020), 179-189. https://doi.org/10.18036/estubtdc.661691

APA	Gençer A, akgeyik e, KAYNAK M, Çelebier M, Berkman M, Sahin S (2020). ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online), 9(2), 179 - 189. 10.18036/estubtdc.661691
Chicago	Gençer Ayşe,akgeyik emrah,KAYNAK Mustafa Sinan,Çelebier Mustafa,Berkman Murat Sami,Sahin Selma ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online) 9, no.2 (2020): 179 - 189. 10.18036/estubtdc.661691
MLA	Gençer Ayşe,akgeyik emrah,KAYNAK Mustafa Sinan,Çelebier Mustafa,Berkman Murat Sami,Sahin Selma ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online), vol.9, no.2, 2020, ss.179 - 189. 10.18036/estubtdc.661691
AMA	Gençer A,akgeyik e,KAYNAK M,Çelebier M,Berkman M,Sahin S ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online). 2020; 9(2): 179 - 189. 10.18036/estubtdc.661691
Vancouver	Gençer A,akgeyik e,KAYNAK M,Çelebier M,Berkman M,Sahin S ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online). 2020; 9(2): 179 - 189. 10.18036/estubtdc.661691
IEEE	Gençer A,akgeyik e,KAYNAK M,Çelebier M,Berkman M,Sahin S "ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET." Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online), 9, ss.179 - 189, 2020. 10.18036/estubtdc.661691
ISNAD	Gençer, Ayşe vd. "ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET". Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online) 9/2 (2020), 179-189. https://doi.org/10.18036/estubtdc.661691