Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection

Didem PEKMEZCİ (Ondokuz Mayıs Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Samsun, Türkiye)
JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES
3 0
Yıl: 2020 Cilt: 5 Sayı: 2 Sayfa Aralığı: 118 - 124 Metin Dili: İngilizce DOI: 10.35229/jaes.690811 İndeks Tarihi: 31-01-2021

Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection

Öz:
A pretreatment albumin (ALB)-to-globulin (GLB) ratio (AGR) with a predictivesignificance has been used as an indispensable marker among cancer types for recurrence andprognosis in human patients. This study aims to determine whether the pretreatment AGR and totalcalcium (tCa), magnesium (Mg), ionised phosphorus (iP), total protein (TP), and haematologyparameters as bedside markers differs in dogs with naturally occurring parvovirus infection (PVI).Fourteen client-owned dogs aged 2-8 months that were naturally infected with parvovirus (PV)were enrolled as the study group. Seven client-owned, healthy dogs of the same age formed thecontrol group. Pretreatment mean complete blood counts, serum tCa, Mg, iP, TP, ALB, globulinGLB and AGR values, were compared between groups. The pretreatment mean WBC, NEU, LYM,EOS, GLB, and TP levels were found to be significantly lower (P < 0.05) in the study group, whencompared to the control group. On the other hand, pretreatment AGR with iP was found to bestatistically higher (P < 0.05) in the study group, when compared to the control group. There was asignificant positive correlation between mean serum GLB and WBC levels in the current study. Asignificant positive correlation between mean serum TP and WBC levels was also found. Thispreliminary study demonstrates that pretreatment serum GLB levels and the AGR as easy,inexpensive, objective, and non-invasive biomarkers could be the new prognostic markercandidates in dogs with naturally occurring PVI.
Anahtar Kelime:

Doğal Parvovirus ile Enfekte Köpeklerde Tedavi Öncesi Serum Albuminin Globuline Oranının Değerlendirilmesi

Öz:
Tedavi öncesi albüminin (ALB) globüline (GLB) oranı (AGO) çeşitli kanser vakalarının nüks ve prognozunun değerlendirilmesinde prediktif öneme sahip ve vazgeçilmez bir belirteçtir. Mevcut çalışmanın amacı ise tedavi öncesi başucu belirteçlerinden AGO ile total kalsiyum (tCa), magnezyum (Mg), iyonize fosfor (iP), total protein (TP) ve hematolojik belirteçlerin doğal olarak parvovirus enfeksiyonu (PVE) şekillenen köpeklerde değişip değişmediğinin belirlenmesidir. On dört adet yaşları 2 ila 8 aylık arasında değişen, doğal parvovirus (PV) ile enfekte köpek çalışma grubunu oluşturmuştur. Yedi adet, aynı yaş aralığında sağlıklı ve sahipli köpek ise kontrol grubunu oluşturmuştur. Tedavi öncesi ortalama total kan sayımı, serum tCa, Mg, iP, TP, ALB, GLB ve AGO değerleri gruplar arasında karşılaştırılmıştır. Tedavi öncesi kontrol grubu WBC, NEU, LYM, EOS, GLB ve TP seviyelerinin kontrol grubuna göre istatiksel (P < 0.05) olarak düşük olduğu tespit edilmiştir. Diğer taraftan çalışma grubunun tedavi öncesi AGO ile iP değerleri kontrol grubuna göre istatiksel olarak (P < 0.05) yüksek bulunmuştur. Serum GLB ile WBC değerleri arasında ise mevcut çalışmada pozitif bir korelasyon bulunmuştur. TP ile WBC değerleri arasında ise güçlü bir korelasyon tespit edilmiştir. Bu öncü çalışma ile tedavi öncesi GLB ile AGO değerlerinin, maliyetsiz, objektif ve non-invazif biyobelirteçler olarak doğal PVE şekillenen köpeklerde yeni prognostik belirteç adayları olabileceği ortaya konulmuştur.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA PEKMEZCİ D (2020). Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection. , 118 - 124. 10.35229/jaes.690811
Chicago PEKMEZCİ Didem Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection. (2020): 118 - 124. 10.35229/jaes.690811
MLA PEKMEZCİ Didem Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection. , 2020, ss.118 - 124. 10.35229/jaes.690811
AMA PEKMEZCİ D Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection. . 2020; 118 - 124. 10.35229/jaes.690811
Vancouver PEKMEZCİ D Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection. . 2020; 118 - 124. 10.35229/jaes.690811
IEEE PEKMEZCİ D "Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection." , ss.118 - 124, 2020. 10.35229/jaes.690811
ISNAD PEKMEZCİ, Didem. "Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection". (2020), 118-124. https://doi.org/10.35229/jaes.690811
APA PEKMEZCİ D (2020). Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES, 5(2), 118 - 124. 10.35229/jaes.690811
Chicago PEKMEZCİ Didem Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES 5, no.2 (2020): 118 - 124. 10.35229/jaes.690811
MLA PEKMEZCİ Didem Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES, vol.5, no.2, 2020, ss.118 - 124. 10.35229/jaes.690811
AMA PEKMEZCİ D Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES. 2020; 5(2): 118 - 124. 10.35229/jaes.690811
Vancouver PEKMEZCİ D Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES. 2020; 5(2): 118 - 124. 10.35229/jaes.690811
IEEE PEKMEZCİ D "Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection." JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES, 5, ss.118 - 124, 2020. 10.35229/jaes.690811
ISNAD PEKMEZCİ, Didem. "Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection". JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES 5/2 (2020), 118-124. https://doi.org/10.35229/jaes.690811
Sayfa Oluşturulma Tarihi
23-04-2024 16:35

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